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Drug-induced alveolar haemorrhage
Published in Philippe Camus, Edward C Rosenow, Drug-induced and Iatrogenic Respiratory Disease, 2010
Abigail R Lara, Marvin I Schwarz
Pulmonary capillaritis was first described in 1957 by Spencer2 and is the most frequent histological pattern associated with DAH. It is characterized by damage of the interstitium including the alveolar capillaries that allows red blood cells and fibrin to leak into the alveolar spaces. The interstitium expands owing to the presence of oedema, fibrinoid necrosis, infiltrating inflammatory cells, and free red blood cells.3 Another characteristic finding is that of neutrophilic interstitial infiltration with many of the neutrophils appearing apoptotic or fragmented (leukocytoclasis) and pyknotic. Other histological features include capillary and rare arteriolar thrombosis, organizing pneumonia, and Type II cell hyperplasia. In severe cases of pulmonary capillaritis, there is complete destruction of the alveolar walls and replacement with necrotic tissue.
Attenuation of streptozotocin induced high fat diet exacerbated dyslipidemia mediated hepatic and aortic injuries in male pigs by camel milk
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Hadiza Bello Rilwan, Sunday Samuel Adebisi, James Abrak Timbuak, Sunday Blessing Oladele, Aliyu Muhammad, Wusa Makena, Adamu Abubakar Sadeeq
A Photomicrograph section of an aorta tissue from the control group (NC) showed normal tunica intima, tunica media, tunica adventitia, and Vasa vasorum characteristics (Figure 6a). A histological section of the aorta in the D-HFD group showed marked tunica intima ulceration, medial cystic necrosis, and some fibrinoid necrosis in the aortic medium (Figure 6b). Photomicrographs of the aorta in the D-HFD + 250 CM group displayed typical tunica intima characteristics, some calcification of the tunica media, and medial cystic necrosis (Figure 6c). Sections from the D-HFD + 500 CM group revealed normal tunica intima, tunica media, and minor disruption of the tunica adventitia (Figure 6d), while D-HFD + MET showed minor tunica intima ulceration, medial cystic necrosis, and tunica adventitia disruption (Figure 6e). For Masson’s trichrome stain, aorta from NC sections showed a normal distribution of reticular fibers in the parenchyma collagen fiber (Figure 7a). The D-HFD section revealed marked disruption/depletion of collagen fiber and extensive ulcers at the tunica intima (Figure 7b). D-HFD + 250 section exhibited remarkable collagen fiber restoration with tunica media ulceration (Figure 7c). D-HFD + 500 section demonstrated marked collagen fiber repair (Figure 7d), while D-HFD + MET aorta showed a slight improvement in collagen fiber distribution with medium ulceration (Figure 7e).