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Disability and impairment in asbestosis and asbestos-related diffuse pleural disease
Published in Dorsett D. Smith, The Health Effects of Asbestos, 2015
Exercise intolerance is a condition in which the individual is unable to perform a physical exercise at the intensity or the duration that would be expected from someone of their age, sex, height, race, and general physical condition. The inability to perform exercise is generally related either to a cardiovascular, respiratory, neurological, or peripheral muscle disorder. When the inability to perform exercise is caused by impaired function of one or more of the major physiological systems, namely the respiratory, the cardiovascular, or the peripheral muscle metabolic system, the result is the amplification of the perceptions of respiratory discomfort, either alone or typically in conjunction with peripheral muscle discomfort/fatigue. In patients with chronic lung diseases, dyspnea sensations are exaggerated during exercise, secondary to the reduced breathing efficiency that results from the deteriorating ventilatory mechanics on the one hand and the increased ventilatory requirements on the other hand.
Chronic iliofemoral vein obstruction – an under-recognized cause of exercise limitation‡
Published in European Journal of Sport Science, 2018
Michael J. Segel, Ronen Reuveny, Jacob Luboshitz, Dekel Shlomi, Issahar Ben-Dov
Normal exercise capacity is maintained when all components of the oxygen transport chain are intact. Reduced cardiac output and breathing reserve (BR), inadequate muscle perfusion due to peripheral arterial disease and neuromuscular causes of exercise intolerance have been extensively explored in the literature. The effect of the venous component of the peripheral vascular bed on exercise capacity has received less attention (Monahan et al., 2001) and venous pathology is rarely if ever listed as a potential cause for exercise limitation (Wasserman, 1997). However adaptive changes in the capacitance of the venous system play an important role in modulating cardiac output (Tyberg, 2002).