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The Concept of Dendrimers
Published in Zahoor Ahmad Parry, Rajesh Pandey, Dendrimers in Medical Science, 2017
Zahoor Ahmad Parry, Rajesh Pandey
Multivalent phosphorus-containing catanionic dendrimers with galactosylceramide analogues were developed by Blanzat et al. [24]. The influence of the multifunctional core, the alkyl chains, and the surface properties of the dendrimers on their stability, cytotoxicity, and antiretroviral properties were reported by the same group in subsequent studies [25, 26]. Galactosylceramide has a high affinity for the V3 loop of the gp120 viral envelope protein of HIV-1, and subsequently prevents viral fusion to the host cell membrane, thus acting as an entry inhibitor. Although the galactosylceramide dendrimers showed good antiretroviral activity, a low therapeutic index associated with cytotoxicity is one of the issues that need to be addressed before these can be considered promising antiretroviral agents. Reports on dendrimer-based anti-HIV therapy continue to appear [27].
PPH-Based Dendrimers as HIV Entry Inhibitors
Published in Anne-Marie Caminade, Cédric-Olivier Turrin, Jean-Pierre Majoral, Phosphorus Dendrimers in Biology and Nanomedicine, 2018
Cedric-Olivier Turrin, Muriel Blanzat
Anionic carbosilane dendrimers have also been formulated with tenofovir, a nucleosidic RT inhibitor, and maraviroc, an entry inhibitor, and topical applications of these formulations in mouse models validated this multi-drug encapsulation approach in terms of anti-HIV-1 activity, cytotoxicity, and vaginal irritation [35,36].
Polymer-based nano-therapies to combat COVID-19 related respiratory injury: progress, prospects, and challenges
Published in Journal of Biomaterials Science, Polymer Edition, 2021
Nanoparticles developed by polymeric materials such as PLGA, PLA, poly(ethylene glycol)-poly(ε-caprolactone) (PEG-PCL), PLA-PEG, and some others have been studied exclusively as nanocarriers for the systematic delivery of drug molecules and biomolecules for the antiviral and other disease treatment (Figure 1).[68–72] Previously, Li et al. developed a unique cocktail therapeutic strategy containing biodegradable polymeric nanoparticles for antiviral treatment.[73] They developed this PEG-PLA-based cocktail nanoparticles to encapsulate HIV-1 entry inhibitor and conjugate with reverse transcriptase inhibitor, resulting in strong virucidal effects against HIV-1.