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Protein- and Polysaccharide-Based Nanoparticles
Published in C. Anandharamakrishnan, S. Parthasarathi, Food Nanotechnology, 2019
S. Priyanka, S. Kritika, J.A. Moses, C. Anandharamakrishnan
Gelatin nanoparticles are preferably used for selective drug delivery of didanosine, an anti-HIV drug, to various target organs. The gelatin nanoparticles, coupled with mannose, are prepared through a two-step desolvation technique. The nanoparticles were analyzed for their particle size, zeta potential, and drug entrapment percentage, which were found to be in the range of 248–325 nm, 6.2 ± 0.12 mV, and 40.2%–48.5% respectively. The coupling of mannose with nanoparticles profoundly increased the uptake of the drug in various vital organs such as lung, liver, and lymph nodes. However, the coupling with mannose increased the particle size during drug loading and the value of zeta potential was decreased (Jain et al., 2008) (Figure 7.3).
Nanomaterials against pathogenic viruses: greener and sustainable approaches
Published in Inorganic and Nano-Metal Chemistry, 2020
Ghazaleh Jamalipour Soufi, Siavash Iravani
Chitosan NPs have been investigated as drug delivery systems/carriers (as an example, the delivery of antiviral drugs), because of their good stability, simple/mild preparation technique, low toxicity, and providing versatile routes of administration.[77] For instance, chitosan NPs were employed for delivery of didanosine (a medication used to treat HIV/AIDS) to improve the systemic and brain targeting efficiency of this drug after intranasal administration. Didanosine-loaded chitosan NPs have been designed via ionotropic gelation of chitosan with tripolyphosphonate anions. Results showed that the brain/plasma, olfactory bulb/plasma and cerebrospinal fluid (CSF)/plasma concentration ratios were higher (P < 0.05) after intranasal administration of didanosine-loaded chitosan NPs or solution than those after intravenous administration of didanosine aqueous solution. It was concluded that intranasal administration and formulation of didanosine-loaded chitosan NPs improved the delivery of drug to CSF and brain.[77]