DMP1

DMP1

Dmp1, or Dentin matrix protein-1, is a signaling molecule and mineralization regulator that is specific to dentin. It is an NCP (non-collagenous protein) that plays a crucial role in the initiation of mineralization and regulates the growth rate and morphology of crystals in the dentine matrix.From: Polymeric Biomaterials, Revised and Expanded [2018], Effect of a new modified polyamidoamine dendrimer biomimetic system on the mineralization of type I collagen fibrils: an in vitro study [2022], Bone Tissue Engineering [2018]

Infrared spectroscopy and imaging

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Published in Elaine DiMasi, Laurie B. Gower, Biomineralization Sourcebook, 2014

Adele L. Boskey

Type X collagen knockout Col X Osteopontin knockout OPN Osteocalcin knockout OCN Phosphaturic hormone on the X chromosome (PHEX) transgenic Dentin sialophosphoprotein (DSPP) knockout Tissue-speci c alkaline phosphatase (TNAP) Mutant SH3BP2 adaptor protein associated with cherubism Dentin matrix protein-1 (DMP1) knockout

Remineralization of human dentin type I collagen fibrils induced by carboxylated polyamidoamine dendrimer/amorphous calcium phosphate nanocomposite: an in vitro study

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Published in Journal of Biomaterials Science, Polymer Edition, 2022

Jing Yang, Jingxian Huang, Hejia Qin, Jindong Long, Xuandong Lin, Fangfang Xie

Remineralization of type I collagen fibrils is a process of mutual interactions between the organic matrix and inorganic minerals [12]. In nature, non-collagen proteins like dentin matrix protein 1 (DMP-1) are implicated widely in the regulation of dentin remineralization [13], which induce crystal nucleation, crystal growth and mineral formation due to the calcium binding capacity and high affinity to collagen fibrils [14]. Research demonstrated that non-collahen proteins are vital for the remineralization process, while they can be replaced by bionic analogues [15–17].

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Infrared spectroscopy and imaging

Remineralization of human dentin type I collagen fibrils induced by carboxylated polyamidoamine dendrimer/amorphous calcium phosphate nanocomposite: an in vitro study