Explore chapters and articles related to this topic
Cancer Incidence and Mortality: In India and Worldwide
Published in Anjana Pandey, Saumya Srivastava, Recent Advances in Cancer Diagnostics and Therapy, 2022
Anjana Pandey, Saumya Srivastava
It was observed that a high prevalence of colorectal cancer is due to bad lifestyle factors, including Westernization, alcohol and red meat consumption, lack of physical activity, etc. (Asano and McLeod, 2002; Park et al., 2005; Larsson and Wolk, 2006; Moskal et al., 2007; Botteri, et al., 2008; Huncharek et al., 2008; Liang et al., 2009; Fedirko et al., 2011; Bagnardi et al., 2015; Bouvard et al., 2015).
Nanotechnologies Assemblies of siRNA and Chemotherapeutic Drugs Codelivered for Cancer Therapeutic Applications
Published in Loutfy H. Madkour, Nanoparticle-Based Drug Delivery in Cancer Treatment, 2022
Colorectal cancer is one of the main causes of death worldwide, and its incidence is increasing as its prognosis remains poor. In addition to the primary surgical procedure, which removes primary and regional tumors and lymph nodes by open surgical resection, colorectal cancer therapy also includes chemotherapy, local ablation by radiation therapy, and targeted therapy, especially for patients with hepatic metastasis or recurrent colon cancer. Currently, different multidrug combinations that combine agents with proven anticancer activity, such as 5-fluorouracil, irinotecan, oxaliplatin, and capecitabine, have been used for colorectal cancer therapy in the clinic [147–150]. As a biologically active metabolite derived from the irinotecan hydrochloride (CPT-11), SN-38 (7-ethyl-10- hydroxycamptothecin) exhibits approximately 1000-fold higher cytotoxicity against various cancer cells compared with CPT-11 [151]. However, the clinical application of SN-38 is limited by its poor solubility in pharmaceutically acceptable media. To overcome this problem, several drug delivery systems (DDSs) have been designed for efficient delivery of SN-38, such as nanoparticles [152,153], liposomes [154], carbon nanotubes [155], and polymeric micelles [156,157].
Case-Based Reasoning
Published in Jay Liebowitz, The Handbook of Applied Expert Systems, 2019
The primary modality of treatment for colorectal cancer is surgery. However, although over two thirds of patients with primary disease undergo potentially curative surgery where all gross tumor is removed, up to 50% of these will eventually die in the ensuing 5 years, the majority from local, regional, or distant tumor recurrence. Adding to the problem is the difficulty in predicting the site of recurrence. This is, at the moment, difficult to do since primary colorectal cancers at different locations in the bowel may have different recurrence patterns.
A convergent synthetic platform for polymeric nanoparticle for the treatment of combination colorectal cancer therapy
Published in Journal of Biomaterials Science, Polymer Edition, 2021
Donghui Zhang, Ling Jiang, Chao Liu
The second leading cause of tumour-related fatalities is the most frequent colorectal tumour. It also has considerable challenges in terms of its successful treatment because most patients are in later stages of the disease [8–11]. Current in situ and early colorectal cancer surgery, radiation and chemotherapy are effective. However, advanced cases do not react to chemical or radiation treatment. Chemotherapy resistance caused by cell death is a major reason for the typical failure in therapy. Colorectal cancer today has a very bad prognosis with a survival rate of 5 years of less than 25%. In the early stages of acute colorectal cancer in patients [12–14], it is so difficult to recognize, penetrate, and kill cancer colorectal cells.
Exploring the anticancer properties of the gum of Ferula gummosa: impact on cytotoxicity, caspase 3/7 activity and apoptosis, and gene expression in SW-480 cells
Published in International Journal of Environmental Health Research, 2023
Cancer is a global leading cause of death, and epidemiological studies predict an increase in cancer incidence in the future (Bray et al. 2018). Colorectal cancer is the second cause of death worldwide, with an estimated 1.9 million newly diagnosed cases each year (Hossain et al. 2022). Laboratory and experimental studies showed an inverse relationship between plant-based diets and the possibility of cancer occurrence (Sun et al. 2021). The increase in colorectal cancer can be attributed to the population’s aging, dietary habits, and increase in risk factors; such as smoking, reduced physical activity, and obesity (Schreuders et al. 2015).
Detection of Colon Cancer Using Image Processing
Published in Cybernetics and Systems, 2023
P. Radhakrishnan, A. Anbarasi, K. Srujan Raju, B. V. Sai Thrinath
Colon cancer detection is a crucial task for histopathologists because they must look at imaging morphology at extremely high magnification, which causes variation between observers (Wahaia et al. 2011). Automation is required for colon cancer detection at any magnification. This article focuses on colon biopsy images with enhanced magnification for the detection of colon cancer. The most prevalent and difficult condition of the modern era is cancer (Devi et al. 2013). Equally crucial is the early detection of the majority of cancers without biopsies. A biopsy should not be performed because it is harmful to the body. The majority of cancers are, in general, brought on by genetic instability and the accumulation of a few molecular changes (Cheng and Sun 2012). Additionally, it results from a special activation of cellular genes that control the molecule’s growth or mitosis. Colorectal cancer is the most prevalent type of cancer that arises in the colon or rectum. In this case, 0.33 represents the maximum number of cancers that are widely recognized across the globe. Colorectal cancer is also known as bowel cancer, colon cancer, and colorectal adenocarcinoma. The primary disadvantage of cancers is that they typically have a poor prognosis and are treated too late. Most cancers have surpassed heart disease as a result of this issue because their primary objective is death at any age. As a result, early cancer detection is crucial. Clinical snapshots can thus be divided into a variety of categories, These kinds of images are high-definition images that provide precise anatomical information about the organ. For instance, MRI, CT, and ultrasonography (USG), among others Functional Medical ImagesIt provides practical and metabolic records of an organ and low spatial decision snapshots. such as PET, SPECT, etc.