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Cervical Dysplasia Diagnosis with Fluorescence Spectroscopy
Published in Mary-Ann Mycek, Brian W. Pogue, Handbook of Biomedical Fluorescence, 2003
Rebecca Richards-Kortum, Rebekah Drezek, Karen Basen-Engquist, Scott B. Cantor, Urs Utzinger, Carrie Brookner, Michele Follen
Cervical neoplasia is a term used to describe both premalignant and malignant lesions in the cervix. Cervical intraepithelial neoplasia (CIN) refers to precancerous changes in the epithelium above the basement membrane that precede invasive cancer. These changes are classified into grades based on the number of undifferentiated cells extending from the basement membrane to the surface epithelium. If undifferentiated cells fill the full thickness of the epithelium from the basement membrane to the surface, the lesion is called carcinoma in situ (CIS). If undifferentiated cells penetrate the basement membrane into the stroma, possibly extending to lymphatic channels and vessels, the lesion is called invasive cancer.
Connective data: Markov chain models and the datafication of cervical cancer and HPV vaccination in Colombia
Published in Tapuya: Latin American Science, Technology and Society, 2021
Oscar Javier Maldonado Castañeda
The National University, using a Markov model, simulated the natural history of cervical cancer and genital warts in a hypothetical cohort of 430,859 Colombian women. These 430,859 virtual women were generated by the algorithm. The parameters were defined from a literature review of national and international studies (UNAL 2011). The Markov chain fits in the ways in which medical science traditionally has represented the development of cervical cancer. This malady has been understood as a disease whose stages are clearly identified. Changes in cervical tissue are organized in four types of cervical intraepithelial neoplasia (CIN) according to their severity, from CIN I that is related to minor damage to CIN IV to metastasis (Benedet and Pettersson 2003, 1). These different stages will define the Markov states of the model.