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Evolution of Structures
Published in Stuart R. Stock, MicroComputed Tomography, 2018
Although bone healing stimulation was reported via administration of adenoviral vectors encoding bone morphogeneic protein-2 (BMP-2) in small animal models (Betz et al., 2007), Egermann et al. (2006) used microCT of standardized iliac crest defects and tibial osteotomies to find the opposite to be true in sheep. The role of osteopontin (OPN) on bone healing in a mouse femoral fracture model, specifically angiogenesis and fracture callus formation, was examined via microCT in wild-type and OPN−/- mice (Duvall et al., 2007). It is sometimes medically necessary to fuse the bones of the spine, and microCT was used to evaluate the effectiveness of a new bone growth factor in a rat spinal fusion model (Lu et al., 2007). MicroCT data suggested that controlled release of a thrombin peptide may enhance healing of critical and noncritical (sized) defects in rabbits (Sheller et al., 2004) and that BMP-silk composite matrices may be useful in healing critical-sized femoral defects in nude rats (Kirker-Head et al., 2006). MicroCT was also used to study an extreme case of healing, the regeneration of limbs in adult newts (Stock et al., 2003; Stock et al., 2004).
Truss implant technology™ for interbody fusion in spinal degenerative disorders: profile of advanced structural design, mechanobiologic and performance characteristics
Published in Expert Review of Medical Devices, 2021
Jessee P. Hunt, Matthew R. Begley, Jon E. Block
The 4WEB truss bioactive surface topography is generated using 3D-printed additive manufacturing methods that create layer-upon-layer of a hierarchical surface roughness that spans from the macro- (Figure 5) to the nano-scale (Figure 6) and resembles the dimensions and morphology of resorption lacunae produced by osteoclastic activity [43]. By mimicking the surface characteristics of native trabecular bone, the truss implant’s rough titanium surface provides a favorable bone remodeling environment to support local bone growth factor expression with direct osteoid deposition and bone formation [15,55].
Three dimensionally printed pearl powder/poly-caprolactone composite scaffolds for bone regeneration**
Published in Journal of Biomaterials Science, Polymer Edition, 2018
Xu Zhang, Xiaoyu Du, Dejian Li, Rongguang Ao, Bin Yu, Baoqing Yu
A recent study[32, 33]. reveals that some nacre proteins act as signaling molecules and could be found in nacre including bone morphogenetic proteins (BMPs). BMP is a bone growth factor in human bone that can activate osteogenetic bone marrow cells both in vivo and in vitro and can lead to bone formation. Atlan et al. used nacre powder to treat bone defects in female patients and found that nacre was osteoinductive.