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Gingiva and Periodontal Tissue Regeneration
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Avita Rath, Preena Sidhu, Priyadarshini Hesarghatta Ramamurthy, Bennete Aloysius Fernandesv, Swapnil Shankargouda, Sultan Orner Sheriff
PDGF is the primary growth factor involved in wound healing, and there are a lot of studies showing its ability to enhance the proliferation and migration of periodontal ligament cells. It is naturally made of the conjugation of polypeptides of growth factor-BB and growth factor-AA, which is encoded by two different genes. It has been demonstrated that all isoforms have an effect on cell proliferation in vitro (Dennison et al. 1994; Oates et al. 1993). It has been shown that PDGF has a chemotactic effect, by which it can promote collagen synthesis, and stimulates hyaluronate synthesis by gingival fibroblasts and fibroblast proliferation.
The therapeutic role of the components of Aloe vera in activating the factors that induce osteoarthritic joint remodeling
Published in Badal Jageshwar Prasad Dewangan, Maheshkumar Narsingrao Yenkie, Novel Applications in Polymers and Waste Management, 2018
Abhipriya Chatterjee, Patit Paban Kundu
Plateletderived growth factor (PDGF) is the first growth factor present in a wound and initiates connective tissue healing through the promotion of collagen and protein synthesis. The most important specific activities of PDGF include angiogenesis, chemotaxis for fibroblasts, and collagen synthesis. The primary effect of PDGF can be its mitogenic activity on mesodermderived cells like fibroblasts, vascular muscle cells, and chon drocytes. Studies supported the role of PDGF in wound healing or stimula tion of matrix synthesis in growth plate chondrocytes.61
Biological Responses in Context
Published in Arthur T. Johnson, Biology for Engineers, 2019
Somatal cell reproduction does not happen without interaction from other cells and tissues. Growth factors are proteins released by certain body cells that stimulate other cells to divide. Thus we find that platelet-derived growth factor (PDGF) is made by blood cells called platelets in response to a wound. Connective tissue cells called fibroblasts are stimulated to divide by PDGF. The result is that the wound begins to heal (Campbell et al., 1999).
Quaternary ammonium salt-modified isabgol scaffold as an antibacterial dressing to improve wound healing
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Vasudha T. K., Anand Kumar Patel, Vignesh Muthuvijayan
Wound healing is an orderly progression of biological and molecular events that occurs in roughly four stages, viz., hemostasis, inflammation, proliferation, and remodeling stages. In the hemostasis phase, platelets arrive at the wound site and clot formation occurs to cover the wound and ward-off bacteria. In the inflammation stage, wound debridement action is performed by macrophages and neutrophils that are recruited to the wound site. These inflammatory cells remove cell debris and bacteria at the wound site. The proliferation stage is characterized by the formation of extracellular matrix proteins, angiogenesis, wound contraction, and keratinocyte migration. In the remodeling phase, collagen fibers deposited in the proliferative phase are aligned in an orderly fashion to increase the tensile strength of the newly formed tissue [1]. Infection is one of the leading causes of impaired wound healing. Infection results in prolonged inflammation where inflammatory cells accumulate at the wound site and release inflammatory cytokines. This triggers the secretion of matrix metalloproteases (MMPs) that destroy the wound healing process. Additionally, production of factors like vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) is also affected. Under these conditions, the transition from the inflammatory to proliferative stage does not occur, preventing the formation of new healthy tissue. It is, therefore, crucial to prevent infection at the wound site [1–3].
A concise review on drug-loaded electrospun nanofibres as promising wound dressings
Published in Journal of Medical Engineering & Technology, 2019
Farzaneh Aavani, Sajedeh Khorshidi, Akbar Karkhaneh
In 2013, Zhiwei Xie and colleagues successfully developed biomimetic nanofibrous scaffold to improve tissue formation. This scaffold contained nanoparticle loaded with two different growth factors (VEGF and PDGF) [61]. The fast and sustained release profile of these two growth factors were investigated at various phases. They demonstrated that if VEGF is introduced in the early stage of wound-healing process, it can promote new blood vessel formation and sequentially bring more nutrition and oxygen to the wound site. In addition, they found that, the presence of PDGF in whole stages of wound healing, will facilitate this process. PDGF is crucial for inflammation, granulation, re-epithelialization and remodelling throughout the phases of wound the healing. Thus, different release profile is required for this purpose. For PDGF, sustained release is requisite, whereas, for VEGF, a relatively quick release is necessitated. So VEGF and PDGF were loaded in sheath and core polymer solution respectively.