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Heavy Metal Poisoning
Published in Charles Theisler, Adjuvant Medical Care, 2023
The heavy metals most commonly associated with poisoning of humans are lead, mercury, arsenic, and cadmium. Heavy metal poisoning may occur as a result of industrial exposure, air or water pollution, foods, medicines, improperly coated food containers, or the ingestion of lead-based paints.
Wastewater Phycoremediation by Microalgae for Sustainable Bioproduct Production
Published in Gokare A. Ravishankar, Ranga Rao Ambati, Handbook of Algal Technologies and Phytochemicals, 2019
Najeeha Mohd. Apandi, Radin Maya Saphira Radin Mohamed, Adel Ali Saeed Al-Gheethi, Amir Hashim Mohd. Kassim
The most commonly found heavy metals in wastewater are Cadmium (Cd), Chromium (Cr), Lead (Pb), Mercury (Hg) and Zinc (Zn) which can cause poisoning to humans and aquatic life. Poisoning can occur through drinking water or food chains since heavy metals tend to accumulate in the food chain. Heavy metals discharged from wastewater into rivers, lakes and the sea might lead the contamination of fishes and vegetables due to their high solubility in aquatic environments (Azimi et al. 2017). On the other hand, heavy metals can remain in the human body for a long time since they are not biodegradable. For example, too much Zn may cause health related diseases such as skin irritations, vomiting and stomach cramps (Azimi et al. 2017). Thus, heavy metal removal using microalgae is efficient, safe and cost effective (Ajayan et al. 2015).
Micronutrients in Healthy Aging and Age-Related Decline in Organ Functions
Published in Kedar N. Prasad, Micronutrients in Health and Disease, 2019
Heavy metals at high concentrations are toxic to humans and animals. Metal homeostasis is regulated by a metal-responsive transcriptional factor (MTF-1). Mutation in the MTF-1 reduced the lifespan of Drosophila melanogaster, suggesting that the wild-type MTF-1 is an essential component for maintaining the normal lifespan. The overexpression of MTF-1 in neurons protects against oxidative damage and prolongs the lifespan of Cu/Zn superoxide dismutase-deficient flies.26
Investigating the effect of the heavy metals cadmium, chromium and lead, alone and in combination on an endothelial cell line
Published in Ultrastructural Pathology, 2023
L van Strijp, M Van Rooy, J Serem, C Basson, Hm Oberholzer
The effect of heavy metal exposure on human health is an important area of interest due to their abundance in the environment. Increased abundance of heavy metals are a result of the use of a wide assortment of metals in industry and processes in daily life. 1 Heavy metals are considered dangerous to human health as they have the ability to bio accumulate in tissues, causing toxicity. 2 Tobacco smoke has carcinogenic, toxic, and genotoxic properties. Cigarette smoke is known to contain both inorganic and organic human carcinogenic compounds. Several heavy metals have been identified in tobacco smoke including cadmium (Cd), chromium (Cr), lead (Pb), copper (Cu), mercury (Hg), manganese (Mn), aluminum (Al), zinc (Zn), and nickel (Ni).2–4 Of these metals, the three most abundant metals are Cr, Cd, and Pb.3,5–7
Microstructural and heavy metal analysis of gallstones prevalent in Jharkhand and its implications in the treatment
Published in Postgraduate Medicine, 2023
Bhavna Sharma, Shubha Rani Sharma
Also, through the present analysis, we have found that heavy metals are present in trace amounts in these gallstones. This can be linked to food and water or any other accidental heavy metal exposure. In some studies, it has been found that the presence of heavy metals in them can cause gallbladder cancer [35]. This information about the linkage of heavy metals with gallbladder cancer can be utilized for discovering the mechanism by which the heavy metals can cause gallbladder cancer so that we can devise ways and means to prevent gallbladder cancer. Also, this can help the practitioners in identifying the possible risk factors that led to the presence of heavy metals in the gallstones of the Jharkhand region as this can eventually initiate gallbladder cancer. Recently the correlation of serum parameters has been linked to gallstone formation and this can used also utilized for prediction of gallstones. [36] Thus, the findings of this study can be a new ray of hope in the treatment and prevention of gallstones.
Effects of hydrated sodium calcium aluminum silicates (HSCAS) in experimentally induced cadmium toxicity in male Japanese quail (Coturnix japonica)
Published in Toxin Reviews, 2022
Affan Nasir, Muhammad Kashif Saleemi, Muhammad Zargham Khan, Aisha Khatoon, Zahoor UlHassan, Zain ul Abidin, Waqas Ahmad, Sheraz Ahmad Bhatti, Muhammad Mairaj Khan, Tariq Jamil, Zahida Fatima, Ishtiaq Ahmed, Ahrar Khan
Heavy metals are a major health risk (Suljević et al. 2020). Of these, cadmium (Cd) is highly toxic heavy metal (Suljević et al.2019) and is significant environmental pollutant that causes pathophysiological responses in many organs. Its exposure causes harmful effects in humans and animals. Exposure to Cd causes functional and morphological changes in liver (Dehn et al.2004, Saleemi et al.2019), kidneys (El-Sharaky et al.2007), testicular degeneration (Lorico et al.2002) oviduct and ovaries (Butt et al. 2018), and biochemical (Tahir et al.2017; Oraby et al. 2021) and morphological variation in gastrointestinal tract and lungs (Saleemi et al.2019). Heavy metal, like Cd absorption into many tissues is very fast due to a pronounced affinity for metallothioneins (Suljević et al.2020). Dietary Cd results in anemia, poor mineralization of the long bones, and reduced body weight in the young Japanese quail. The adverse effects of Cd have also been associated with teratogenesis (Rogers et al.1996) and carcinogenesis (Misra et al.1996).