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Oncoplastic parenchymal resection
Published in Steven J. Kronowitz, John R. Benson, Maurizio B. Nava, Oncoplastic and Reconstructive Management of the Breast, 2020
Steven J. Kronowitz, John R. Benson, Maurizio B. Nava
Breast-conserving surgery for invasive breast cancer has been shown to have outcomes equivalent to mastectomy in terms of overall and breast cancer-specific survival in multiple randomized controlled trials.1,2 The Early Breast Cancer Trialists’ Collaborative Group analyzed data from randomized controlled trials which included 42,000 women over 78 trials. In a comparison of mastectomy versus lumpectomy and radiation, at 15 years, there was no difference in overall survival or breast cancer-specific survival among both groups.3 With regards to local recurrence, improvements in methods of margin assessment and administration of systemic therapy have led to a decrease in rates of local recurrence since these randomized trials were performed. In a longitudinal analysis done by Cabioglu and colleagues, investigators looked at ipsilateral breast tumor recurrence in patients with invasive breast cancer treated between 1970 and 1996. Patients treated prior to 1994 had a significantly higher local recurrence rate compared to those treated after 1994, 5.7% versus 1.3% (p = 0.001). Those patients treated after 1994 were also less likely to have positive or unknown margins and more likely to receive systemic therapy.4 Accordingly, the option of breast-conservation therapy has become a standard of care for patients being treated with invasive breast cancer.
Breast
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
Breast conservation therapy (see also ‘Oncoplastic surgery’) Small lump – lumpectomy (1 cm margin) + radiotherapy + node sampling/clearance, adjuvant radiotherapy. RT is a mandatory part of BCT; it reduces recurrence from 40% to 8%.
Breast Cancer
Published in Andrew Stevens, James Raftery, Breast Cancer Health Care Needs Assessment, 2018
Randomized controlled trials comparing BCT, axillary node dissection and post-operative radiotherapy with total mastectomy and axillary node dissection have demonstrated similar local recurrence-free and overall survival rates (Table 5). Breast conservation therapy is not always considered suitable for women with multifocal disease, large tumours, small breasts or when disease is beneath the nipple.
Appearance investment, coping strategies, and psychosocial adjustment in male patients with head and neck cancer
Published in Journal of Psychosocial Oncology, 2023
The construct of body image has recently been applied to understand patients’ experiences with cancer. Considerable research has been devoted to comparing body image satisfaction among women undergoing various surgical procedures.7 Studies regarding appearance changes among patients with breast cancer have documented that mastectomies and reconstructions were more likely to induce poor self-esteem, self-consciousness, and depression than breast-conservation therapy. Furthermore, the intensity of body image dissatisfaction among patients with breast cancer has been found to be positively associated with several variables related to psychological adjustment, including depression, anxiety, and quality of life.8,9 These findings reflect that body image contributes to general psychosocial adjustment, and that among patients with breast cancer, body image dissatisfaction is associated with adverse psychosocial outcomes.
Predicting the Survival of Triple-Negative Breast Cancer in Different Stages: A SEER Population Based Research Referring to Clinicopathological Factors
Published in Cancer Investigation, 2020
Si-Si Chen, Shou-Ching Tang, Kai Li, Jie Wu, Xiang Li, Hong Ren, Xin Sun
Multivariate Cox proportional hazards model showed surgery and chemotherapy were significantly associated with improved OS and DSS of TNBC patients in all stages. Previous studies had reported that chemotherapy could significantly improve the survival of TNBC patients, and was the only systemic therapy to improve TNBC outcomes (28). Surgery was the most important to the prognosis of TNBC. On the other hand, our study found that radiotherapy did not an independent prognostic factor for TNBC in stage I and stage IV, but it is beneficial to patients with stage II and stage III. It was worth noting that nearly 40% of surgery patients in stage I received radiotherapy after breast conservation surgery and these patients will influence the independent impact of radiotherapy variable on OS and DSS. Previous research showed that breast conservation therapy combined with radiation might be more appropriate than mastectomy for patients with TNBC in stage I and stage II (29,30).
Reduction mammoplasty and mastopexy in the previously irradiated breast – a systematic review and meta-analysis
Published in Journal of Plastic Surgery and Hand Surgery, 2021
Anne Kathrine Lorentzen, Jørgen Lock-Andersen, Louise Wichmann Matthiessen, Tobias Wirenfeldt Klausen, Lisbet Rosenkrantz Hölmich
Breast cancer is the most common cancer diagnosed in women, and is the second leading cause of female cancer mortality in the Nordic countries [1]. Screening programs and improved technology for early detection ensures that more patients are diagnosed in early stages. Breast conservation therapy (BCT) for breast cancer entails lumpectomy followed by total breast irradiation, and is currently the recommended treatment for early stage breast cancer [2,3].