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Seminal Plasma Hypersensitivity and Immediate Contact Skin Reactions to Bodily Fluids
Published in Ana M. Giménez-Arnau, Howard I. Maibach, Contact Urticaria Syndrome, 2014
In 2002, men experiencing severe fatigue, low-grade fevers, nasal congestion, burning eyes, concentration difficulties, irritability, and flulike symptoms occurring after ejaculation were described.[21] This condition was termed postorgasmic illness syndrome (POIS).[22] Criteria for establishing a diagnosis of POIS based on demographic characterization of 45 men with this condition include the following: 1) a flulike state, extreme fatigue or exhaustion, muscle weakness, mood disturbances/irritability, memory/concentration difficulties, incoherent speech, nasal congestion, rhinorrhea, and itching eyes; 2) immediate or slightly delayed onset of symptoms after ejaculation; 3) occurrence in more than 90% of ejaculation events; 4) duration for two to seven days; and 5) spontaneous resolution.[22] Reactions are speculated to be the result of an autoallergic reaction to the male’s own semen involving IgE and cell-mediated immune responses.[22] Successful desensitization of two men using their own semen was reported.[23] However, the risk of the male subjects developing spermatozoa autoantibodies using this approach has not been adequately addressed. Further investigation of POIS is warranted because it appears to be affecting growing numbers of men.
Postorgasmic illness syndrome: potential new treatment options for a rare disorder
Published in Scandinavian Journal of Urology, 2020
Hudson Pierce, Jonathan Fainberg, Christopher Gaffney, Ahmad Aboukhashaba, Aleem Khan, James Kashanian
Postorgasmic illness syndrome (POIS) is a rare postejaculatory disorder first described by Waldinger and Schweitzer in 2002 [1]. In their seminal case report, they described two men experiencing rapid onset of a number of flu-like symptoms after orgasm, including extreme fatigue, feverishness, myalgia, and difficulty concentrating. These symptoms appeared within minutes post-orgasm, persisted for 4–7 days, and resolved spontaneously. The men abstained from ejaculation afterward and ceased or diminished sexual activity in order to avoid symptoms.