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Klüver-Bucy Syndrome
Published in Alexander R. Toftness, Incredible Consequences of Brain Injury, 2023
Hypersexuality as a symptom includes a sudden increase of highly sexual behaviors such as making indiscriminate sexual advances, attempts at the inappropriate sexual touching of others, and general sexual disinhibition. All of these behaviors tend to be “exhibitionistic” such that the person performs these actions and makes these comments in the presence of others instead of hiding them (Terzian & Ore, 1955). Many cases describe medical staff needing to be careful around such patients to ensure that they avoid the act of groping during medical examinations. Hypersexuality is frequently reported in KBS cases, with one review finding nearly 96% of cases in adolescents and adults included this symptom (Clay et al., 2019).
Neurology in Documentaries
Published in Eelco F. M. Wijdicks, Neurocinema—The Sequel, 2022
The motor symptoms of chorea (when awake) are constantly present and may involve head movements and tongue protrusion. Movements may be difficult to initiate, and dystonia may occur (abnormal positioning and tics). Walking is unsteady with ataxic features and may also include dystonic posturing. Psychiatric symptoms include a combination of irritability and apathy followed by cognitive decline. Hypersexuality and paraphilias have been noted. The last clinical stage is marked by devastating motor symptoms, full dependence on others for care, and marked dementia. Nursing home placement is typical.16
Endocrine Therapies
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
In the UK, CPA is recommended by NICE for the prevention of tumor flare during initial gonadorelin antagonist therapy, for the long-term palliative therapy of prostate cancer where gonadorelin antagonists or orchidectomy are contraindicated or not tolerated, and for the treatment of hot flashes during gonadorelin antagonist therapy or after orchidectomy. Clinical trials have shown that objective responses can be obtained in 33% of patients with advanced prostate cancer, and stabilization of the disease can be achieved in 40% of patients. It is also used to treat hypersexuality and sexual deviation in males. In some countries it is used for benign prostatic hyperplasia, androgen-related dermatological conditions (such as acne, seborrhea, hirsutism and androgenic alopecia), and a number of sex-related disorders (e.g., precocious puberty and a component of hormone replacement therapy for trans women). A formulation combined with ethinyl estradiol (e.g., co-cyprindiol) has also been available as a contraceptive since 1997 (e.g., DianetteTM) which is also used to treat acne in females of child-bearing age refractory to topical therapy or oral antibacterials, and for hirsutism. However, it is no longer recommended for contraceptive purposes in the UK. CPA is not FDA approved for use in the US due to concerns about its hepatotoxicity.
What’s in a Name? A Phenomenological Exploration of Hypersexuality Narratives
Published in International Journal of Sexual Health, 2022
Natasha Knack, Dave Holmes, Chad Hammond, J. Paul Fedoroff
While hypersexuality is often used to describe any sexual thoughts or behaviors deemed excessive or difficult to control, Hypersexual Disorder refers to a formal diagnosis, characterized by “typically a normophilic (but sometimes paraphilic) response in which normal sexual interest and behavior are exaggerated, ritualized, or disinhibited” (Walters et al., 2011, p. 1310); this diagnosis was proposed but ultimately rejected for inclusion in the DSM-5. Kafka’s (2010) proposed diagnostic criteria for Hypersexual Disorder have been criticized as being over-inclusive, which may cause normal variations in sexual behavior to be misdiagnosed as sexual disorders (Samenow, 2011). Moser (2011) argued that a lack of empirical evidence exists to support Hypersexual Disorder as a distinct psychiatric disorder and suggested that the symptoms associated with this proposed disorder may be better explained by other pathologies. He noted that, “If the nosology of mental disorders is to be useful, a symptom of another disorder should not be identified as its own disorder” (Moser, 2013, p. 52). See Appendix A in supplemental materials for Kafka’s proposed criteria and Moser’s related criticisms.
The pharmacologic treatment of problematic sexual interests, paraphilic disorders, and sexual preoccupation in adult men who have committed a sexual offence
Published in International Review of Psychiatry, 2019
Belinda Winder, J. Paul Fedoroff, Don Grubin, Kateřina Klapilová, Maxim Kamenskov, Douglas Tucker, Irina A. Basinskaya, Georgy E. Vvedensky
These three aspects of problematic sexual functioning (deviant sexual interest, hypersexual cognition, and hypersexual behaviour) each represent potential ways to understand individuals who have committed a sexual offence, or who are concerned that they may do so. They are each considered problematic, since they may be associated with distress in self or others, functional impairment, and/or the commission of sexual crimes. It should be noted that the DSM-5 does not list ‘hypersexuality’ as a disorder. The Canadian author in this paper (PF) reframes complaints of this type as ‘sexual frustration’, i.e. not inherently pathological, and treatable via facilitation of consensual sexual activities. Nevertheless, the other authors of this paper consider the concept to be a useful heuristic that identifies a clear treatment target.
The Psychometric Properties of the Hypersexual Behavior Inventory Using a Large-Scale Nonclinical Sample
Published in The Journal of Sex Research, 2019
Beáta Bőthe, Márton Kovács, István Tóth-Király, Rory C. Reid, Mark D. Griffiths, Gábor Orosz, Zsolt Demetrovics
Hypersexuality is becoming a widely studied behavior (e.g., Montgomery-Graham, 2016; Schultz, Hook, Davis, Penberthy, & Reid, 2014; Womack, Hook, Ramos, Davis, & Penberthy, 2013). Furthermore, the conceptualization of hypersexuality has started to converge as a result of the proposed diagnostic criteria by Kafka (2010) and subsequent Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), field trial of the proposed criteria (Reid, Carpenter, et al., 2012). Hypersexuality refers to excessive and uncontrollable sexual fantasies, urges, and behaviors accompanied by significant personal distress and adverse consequences. Individuals with hypersexuality use sexual fantasies, urges, and behaviors to cope with stress or negative emotions, such as anxiety or depression. The excessive time spent with these sexual fantasies, urges, and behaviors leads to conflicts in other important aspects of the individual’s life (e.g., obligations or goals) and can cause physical and/or emotional harm to the individual with hypersexual behavior or others. In some extreme cases it could lead to suicidal behavior (Chatzittofis et al., 2017). Although individuals with hypersexuality try to control or reduce their sexual fantasies, urges, and behavior, they experience multiple unsuccessful efforts, often returning to previous behavioral patterns (Kafka, 2010).