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Mechanisms of Fibril Formation and Cellular Response
Published in Martha Skinner, John L. Berk, Lawreen H. Connors, David C. Seldin, XIth International Symposium on Amyloidosis, 2007
Martha Skinner, John L. Berk, Lawreen H. Connors, David C. Seldin
Koyama J, Ray-Sequin PA, Falk RH. Longitudinal myocardial function assessed by tissue velocity, strain, and strain rate tissue Doppler echocardiography in patients with AL (primary)cardiac amyloidosis. Circulation 2003;107:2446-52.
Interleukin-10 Levels are Associated with Doxorubicin-Related Cardiotoxicity in Breast Cancer Patients in a One-Year Follow-Up Study
Published in Immunological Investigations, 2022
Michelle Teodoro Alves, Ricardo Simões, Rodrigo Mendonça Cardoso Pestana, Angélica Navarro de Oliveira, Heloísa Helena Marques Oliveira, Cintia Esteves Soares, Adriano de Paula Sabino, Luciana Maria Silva, Karina Braga Gomes
Two-dimensional color tissue Doppler echocardiography was performed at T0, T1 and T2 according to American Society of Echocardiography recommendations (Lang et al. 2015). The following measurements were taken over three consecutive cardiac cycles: the dimensions of the left ventricle; left atrial volume; parietal thickness; left ventricular mass index; LVEF; and color Doppler images of all valves. Left ventricular diastolic function assessment was performed using the 2016 American Society of Echocardiography and European Association of Cardiovascular Imaging recommendations (Nagueh et al. 2016). The measured parameters included early left ventricular filling (E-wave), peak atrial filling (A-wave), E/A ratio, E-wave deceleration time and isovolumic relaxation time. Tissue Doppler myocardial velocities were obtained at the medial and in the lateral mitral annulus, in four-chamber view, for measurement of the peak early diastolic velocity. Subjects were classified as having normal function, diastolic dysfunction grade II (pseudonormal pattern) and diastolic dysfunction grade III (restrictive pattern), according to the definitions published by the 2016 American Society of Echocardiography recommendations. Subclinical dysfunction (i.e., asymptomatic condition) was diagnosed by left ventricular systolic and/or diastolic dysfunction.
The effect of biological DMARDs on the risk of congestive heart failure in rheumatoid arthritis: a systematic review
Published in Expert Opinion on Biological Therapy, 2018
Milad Baniaamam, Walter J. Paulus, Annelies B. Blanken, Michael T. Nurmohamed
In contrast, Çetin et al. prospectively investigated the effect of infliximab in RA patients on the LV function controlled by prednisolone therapy after 3-month administration. An improvement of only one diastolic function parameter (E/E′) was found in the infliximab-treated compared to the prednisolone-treated patients [20]. Ikonomidis et al. [21] conducted an observational trial investigating both acute and chronic effects of anakinra therapy. In the acute study, they observed the effect of anakinra on the cardiac function of 23 RA patients administrated with anakinra or placebo at baseline and after 3-h. To serve as control, this was repeated in a double-blinded controlled crossover manner after a washout period of 48-h. They observed an improvement of the systolic as well the diastolic function assessed by tissue Doppler echocardiography. In the chronic study, they compared echocardiographic results of 23 RA patients before and after 30-day anakinra treatment controlled by 19 prednisolone-treated RA patients. Similarly, the chronic study showed a significant improvement of the diastolic and systolic cardiac function after anakinra administration. However, no effect was observed in the prednisolone-treated control group [21]. Furthermore, Santos et al. used a noninvasive hemodynamic beat-to-beat monitoring system to observe on the indexed cardiac output (CO) and stroke volume (SV) during 2-h before and after infusion with infliximab in 14 RA patients without history of CHF. The same group served as control, as the same procedure was repeated 2 weeks later after infusion with saline. They showed a significant reduction of SV and CO output after infusion with infliximab, subsequently −13% and −9%, in contrast to the control group which did not show any difference after infusion with saline [22].
Evaluation of atrial electromechanical properties in patients with masked hypertension
Published in Clinical and Experimental Hypertension, 2020
Selçuk Özkan, Ömer Çağlar Yılmaz, Bunyamin Yavuz
Tissue Doppler echocardiography was performed by transducer frequencies of 2.5 to 3.5 MHz, adjusting the spectral pulsed Doppler signal filters until a Nyquist limit of 15 to 20 cm⁄ s, and using the minimal optimal gain. The monitor sweep speed was set at 50 to 100 mm⁄ s to optimize the spectral display of myocardial velocities. In apical four-chamber view, the pulsed Doppler sample volume was subsequently placed at the level of LV lateral mitral annulus, septal mitral annulus, and right ventricular tricuspid annulus. Tissue Doppler pattern is characterized by a positive myocardial systolic wave (S) and two negative diastolic waves: early (E’) and atrial (A’). Every effort was made to align the pulsed wave cursor that the Doppler angle of incidence was as close to 0 as possible to the direction of these walls. Time intervals from the onset of the P wave on surface electrocardiography to the beginning of A wave (PA), representing AEMD, were obtained from the lateral-mitral annulus, septal mitral annulus, and right ventricular (RV) tricuspid annulus and named as lateral PA, septal PA, and RV PA, respectively. The timing of mechanical activation of each reference point, namely lateral mitral, septal mitral, and RV tricuspid annuli, depends on the distances of these points to sinus node, i.e., the RV tricuspid annulus is the earliest and lateral mitral annulus is the latest points to be activated by the impulse arising from sinus node. Therefore, it is hypothesized that the difference between any two reference points reflects the mechanical delay between these two points. The difference between septal PA and RV PA was defined as intra-right AEMD (septal PA-RV PA), the difference between lateral PA and septal PA was defined as intra-LA electromechanical delay (lateral PA-septal PA), and the difference between lateral PA and RV PA (lateral PA-RV PA) was defined as inter-AEMD (5).