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Magnetic Nanoparticles for Cancer Diagnosis
Published in D. Sakthi Kumar, Aswathy Ravindran Girija, Bionanotechnology in Cancer, 2023
R. G. Aswathy, D. Sakthi Kumar
Owing to the inherent magnetic properties, MNPs have been explored in various emerging magnetic-based multi-modal imaging modalities. It includes (a) magnetic particle imaging (MPI), (b) magneto-motive ultrasound (MMUS) imaging, and (c) magneto-photoacoustic (MPA) imaging [129–131]. MPI is explored in combination with MRI, whereas MMUS and MPA are used in conjunction with ultrasound (US) imaging. In the above mentioned imaging modalities, the inherent magnetic behavior is explored and hence the integration of optical or radioactive component is completely avoided. Although these magnetic particles-based novel imaging modalities are in their infancy, comprehensive information on each of these modalities will be briefly discussed.
Fetal echocardiography
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Caroline K. Lee, Erik C. Michelfelder, Gautam K. Singh
Myocardial Performance Index The myocardial performance index (MPI) was originally described by Tei and colleagues in 1995 (35). The MPI is in actuality an index of global ventricular function, as calculation of the index incorporates both diastolic and systolic time intervals into assessment of ventricular function. The MPI is calculated as (IRT + ICT)/ET,
Medical Physics Journals during the Time of COVID-19
Published in Kwan Hoong Ng, Magdalena S. Stoeva, Medical Physics During the COVID-19 Pandemic, 2021
Slavik Tabakov, Perry Sprawls, Paolo Russo, Iuliana Toma-Dasu, Jamie Trapp, Michael D. Mills, Simon R. Cherry, Stoeva Magdalena
MPI has two online open-access issues per year plus a Special Issue related to Medical Physics History. This year, the two regular issues will be joined by two or three Special History issues, thus showing a small increase in volume.
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery
Published in Expert Opinion on Drug Delivery, 2022
D. Stanicki, T. Vangijzegem, I. Ternad, S. Laurent
Nevertheless, the advent of advanced technologies, such as magnetic particle imaging (MPI), which due to their specificity with respect to MNPs, should provide concrete solutions to constraints encountered with current imaging solutions (such as ensuring the quantitative monitoring of the release of an active ingredient within a diseased tissue). As a result, and due to the continuous evolution of this field of activity, we believe that over the next few decades medical devices based on MNPs will be applied in the clinical field.
Probing the drug delivery strategies in ischemic stroke therapy
Published in Drug Delivery, 2020
Qiong Wu, Rong Yan, Jingjing Sun
The prognosis of ischemic stroke largely depends on the blood flow reconstruction speed in the ischemic brain tissue; the faster the blood flow reconstruction speed, the better the patient's prognosis. For suspected cases, routine evaluation is required, including diagnostic imaging. The real-time and accurate imaging of cerebral ischemic lesion is essential for diagnosing and safely treating patients with a stroke (Merino & Warach, 2010). Various imaging strategies have been developed, including near-infrared imaging (NRIS), ultrasound imaging, magnetic resonance imaging (MRI), and computed tomography (CT) (Essig et al., 2013; Molad et al., 2017). Nanomaterials also have been used for more efficient and accurate stroke diagnoses. Platelets tend to bind to injured vasculature. This property is the basis for the fabricated platelet (PLT) membrane-derived biomimetic nanobubbles developed for ultrasound monitoring of ischemic stroke lesions. Nanobubbles preferentially accumulate in the stroke's ischemic region and can be monitored by real-time contrast-enhanced ultrasound imaging. This can be beneficial for the proper treatment of strokes (Li et al., 2018). Magnetic particle imaging (MPI) is a new tomographic imaging method with many advantages: it is radiation-free, has a superior temporal resolution, and is easy to operate (Gleich & Weizenecker, 2005; Weizenecker et al., 2009). Peter et al., investigated MPI capabilities in detecting ischemic lesions in a murine model of ischemic stroke. After giving superparamagnetic iron oxide nanoparticles as a contrast agent, the MPI imaging's signal strength was comparable to that of a small animal MRI scanner in detecting ischemic brain regions. However, the acquisition time of MPI imaging was shorter, and it had a higher resolution, which could help precisely predict the patient's condition (Ludewig et al., 2017).
Investigation of microstructure evolution and mechanical properties in cardiac tissue
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2020
N. Tueni, J. Vizet, M. Genet, A. Pierangelo, J. M. Allain
MPI has emerged as a successful technique to explore biological tissues (Pierangelo et al. 2013). It exploits the polarization of the light, which is very sensitive to detect modifications in the structure of tissues on a microscopic scale. This technique enables the complete polarimetric characterization of a tissue by the simultaneous measurement of various biophysical quantities related to its scattering (depolarization) or anisotropy (phase retardance, azimuth of the birefringence, etc.) properties.