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Mental Recovery
Published in Stijn Geerinck, Reconstructing Identity After Brain Injury, 2022
I often felt strengthened by a special and sudden feeling of useful rancour. It proved to be key in the fight for preservation. I managed to feel a controlled form of rage against the circumstances, without wasting energy on counterproductive ways of venting. On the contrary: it was a source of energy. I called it ‘a specialist’s way of fighting back’. I made sure not to take my frustration and anger out on others, but to only use it for fighting the physical and mental impairments instead.
Chronic Fatigue Syndrome: Limbic Encephalopathy in a Dysregulated Neuroimmune Network
Published in Jay A. Goldstein, Chronic Fatigue Syndromes, 2020
The irritability that CFS patients have is usually intermittent. Some patients relate it to frustration with the illness, and others cannot understand it. “Rage attacks” with violent lashing out are not infrequent. Certain medications for treatment of rage attacks (lithium, propanolol) are not effective, but others (buspirone, fluoxetine) may be. As with other CFS symptoms, if the entire syndrome improves, so does the irritability.
The role of school∗
Published in Carlotta Zanaboni Dina, Mauro Porta, James F. Leckman, Understanding Tourette Syndrome, 2019
Carlotta Zanaboni Dina, Mauro Porta
TS students’ Social Impairment is sometimes due to their guilt because of dysfunctional behaviours towards schoolmates. A typical reaction is rage outbursts with verbal or physical aggression (e.g. to yell at schoolmates, to throw others’ objects against the wall and break them). Especially when TS has an ADHD or OC component, rage outbursts are frequent and interfere with school relationships (Marcks et al, 2007).
Glyceraldehyde-derived advanced glycation end-products are associated with left ventricular ejection fraction and brain natriuretic peptide in patients with diabetic adverse cardiac remodeling
Published in Scandinavian Cardiovascular Journal, 2022
Yuushi Yasuda, Hirofumi Aoki, Wataru Fujita, Kousuke Fujibayashi, Minoru Wakasa, Yasuyuki Kawai, Hiroaki Nakanishi, Kazuyuki Saito, Masayoshi Takeuchi, Kouji Kajinami
TNFα is produced primarily in macrophages, and elevated levels of TNFα in patients with DM have been shown to be associated with micro- and macrovascular complications [26]. TNFα is known to reduce myocardial contractility and to increase tissue fibrosis, contributing to cardiac failure [27]. A previous study reported that accumulation of RAGE and of RAGE ligands can propagate further inflammation and result in long-term complications in patients of DM [28]. The cardiac accumulation of AGEs in diabetes also represents an important inflammation trigger. Sustained activation of TNF signaling is known to induce cardiomyocytes apoptosis and remodeling through the activation of cell death pathways [29]. In the present study, serum TNFα also was elevated, and levels of this cytokine were highly associated with LVEF and BNP in patients with DbCR. Furthermore, there was a significant positive association between Glycer-AGE and TNFα levels in patients with DbCR, suggesting the importance of inflammation induced by the AGE-RAGE axis on the progression of DbCR.
Pulmonary delivery of a recombinant RAGE antagonist peptide derived from high-mobility group box-1 in a bleomycin-induced pulmonary fibrosis animal model
Published in Journal of Drug Targeting, 2022
Chunxian Piao, Chuanyu Zhuang, Min Kyung Ko, Do Won Hwang, Minhyung Lee
Although some IPF treatments have improved patient outcomes, additional therapies based upon newly identified molecular factors underlying the pathogenesis of IPF should be developed. One of the important factors in progression of IPF is receptor for advanced glycation end products (RAGE) [19]. It was previously reported that knocking out the RAGE signal protected the lungs from IPF [20,21], suggesting RAGE inhibition as a target of IPF treatment. RAGE is a pattern recognition receptor for pro-inflammatory reactions [22,23] and is involved in various cellular activities such as proliferation, migration, inflammation and apoptosis [24]. The ligands for RAGE include high mobility group box-1 (HMGB-1), advanced glycation end products (AGEs), S100 protein and β-amyloid [23]. On binding with ligands, RAGE can activate the mitogen-activated protein kinase (MAPK) signal pathway, resulting in activation of nuclear factor-κB (NF-κB) [25,26]. Activation of the RAGE signalling pathway induces the expression of various genes, including those for pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) [27]. Therefore, RAGE signalling induces inflammatory reactions in lung diseases such as IPF and acute lung injury (ALI). In addition, activation of the RAGE signalling pathway induces RAGE gene expression, suggesting positive feedback regulation of RAGE [28].
The role of soluble receptor for advanced glycation end-products (sRAGE) in the general population and patients with diabetes mellitus with a focus on renal function and overall outcome
Published in Critical Reviews in Clinical Laboratory Sciences, 2021
Mieke Steenbeke, Sander De Bruyne, Marc De Buyzere, Bruno Lapauw, Reinhart Speeckaert, Mirko Petrovic, Joris R. Delanghe, Marijn M. Speeckaert
Several treatment options have been proposed to reduce the concentrations of AGEs and the expression of RAGE, and to increase the levels of sRAGE. Arterial stiffness and blood pressure can be lowered by decreasing serum AGE concentrations and by elevating sRAGE levels. The load of AGEs can be countered by limiting the consumption of AGE-rich products, cooking in moist heat at low temperatures, limiting the duration of cooking, and ceasing to smoke cigarettes. Multiple drugs (e.g. ACE inhibitors, angiotensin-II receptor blockers, statins, metformin, aminoguanidine, vitamins, and AGE breakers) inhibit the formation of or reduce the concentration of AGEs. Some drugs have demonstrated the potential to reduce arterial stiffness to a certain degree, as reviewed by Prasad and Mishra [68]. Animal studies have shown that systemic administration of sRAGE could have beneficial effects [10,13,80,81].