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Test of time and test of treatment
Published in Caroline J Rodgers, Richard Harrington, Helping Hands: An Introduction to Diagnostic Strategy and Clinical Reasoning, 2019
Caroline J Rodgers, Richard Harrington
Red flags are: Poor oral intake or decreased urine output (decreased frequency of wet nappies).Persistent listlessness, drowsiness and reduced interaction.A non-blanching rash, neck stiffness, photophobia, headache, and a bulging fontanelle in babies.Laboured breathing, wheezing or stridor.Continuous crying, or a weak cry in babies.Significant parental concern.
Physiological interpretation of pressure waveforms
Published in John Edward Boland, David W. M. Muller, Interventional Cardiology and Cardiac Catheterisation, 2019
Most patients with mitral stenosis present with dyspnoea on effort and these patients have elevated PAW pressures and, more importantly, elevated pulmonary capillary pressure which causes the symptoms. Pulmonary artery pressures are often only mildly elevated (passive pulmonary hypertension). At times these symptoms are replaced by listlessness and fatigue. Haemodynamically the latter patients have much higher PA pressures, higher pulmonary vein resistance and slightly higher PAW and LA pressures, with a much lower cardiac output. Such patients develop what Grossman refers to as ‘second stenosis’ from pulmonary vascular disease affecting distal arterioles and the capillary bed (active pulmonary hypertension).8 The cause of these reactive changes is uncertain. The latter group shows clinically and on the electrocardiogram (ECG) the signs of pulmonary hypertension and right ventricular pressure overload. When the active pulmonary hypertension becomes severe, prognosis is worsened.
Global prevalence and international perspective of paediatric gastrointestinal disorders
Published in Clarissa Martin, Terence Dovey, Angela Southall, Clarissa Martin, Paediatric Gastrointestinal Disorders, 2019
Shaman Rajindrajith, Niranga Devanarayana, Marc Benninga
Cyclical vomiting syndrome (CVS) is a clinical entity associated with recurrent episodes of severe nausea and vomiting that may last for hours to days with well-demarcated symptom-free intervals. The disorder is typically associated with negative laboratory, endoscopic and radiological test results. There is a stereotypical pattern of symptoms in most of the individuals with regard to time of day, duration and onset of symptoms. Vomiting begins late night or early morning with intense nausea, often triggered by psychological distress. Associated symptoms include pallor, listlessness, retching, abdominal pain, headache and photophobia (Rasquin et al., 2006; Li et al., 2008).
Can sensory discrimination ability in children with low functioning autism be used as an index of cognitive ability—an exploratory study
Published in International Journal of Developmental Disabilities, 2023
Subsequent analysis of the coded behaviours revealed that in the context of the research question, the behaviours displayed by the children with LFA can be pigeon-holed into 3 categories—(a) behaviours reflecting an interest to explore the stimulus, (b) behaviours reflecting that the stimulus is perceived to be obnoxious and (c) behaviours displaying a listlessness akin to indifference towards the stimulus. Congruent with our initial theoretical considerations, the afore-mentioned behaviours were conceptualized under three paradigms, viz.ApproachWithdrawalApathetic
The Relationship between Oxidative Stress and Anxiety in a Healthy Older Population
Published in Experimental Aging Research, 2021
Karen Savage, Davy Kingshott, Andrew Gubko, Alicia WT Thee, Tamer Burjawi, Kevin Croft, Jerome Sarris, Con Stough
BMI was found to be an influencing factor of the mood component of energy levels as a significant predictor of Fatigue-inertia and is consistent with the findings of Schur, Noonan, Smith, Goldberg, and Buchwald (2007) where BMI predicted fatigue in chronic disorders. The Fatigue-Inertia scale is designed to measure weariness or listlessness. This suggests that the scale is a measure of motivation or energy levels as a precursor to activity, which is a common symptom observed in conditions such as Major Depressive Disorder (MDD). Higher BMI is also observed in MDD, where it is likely to share common biological underpinnings of sickness behavior or adjustment of metabolism. Interestingly, a relationship between BMI and Vigor-activity was not found, where a negative strong relationship is observed in the literature, with physical activity the main link (e.g., Garatachea et al., 2015; Rejeski and Miholko, 2001)
Encephalitis lethargica in Peru
Published in Journal of the History of the Neurosciences, 2021
Santiago Stucchi-Portocarrero, Miguel Humberto Tomas-Miranda
In the acute phase of the illness, there were psychiatric signs and symptoms, such as hypomanic excitement, delirium, psychosis, hallucinations, catatonic stupor, hysteria, insomnia, irritability, and anxiety attacks (Delgado 1993; Foley 2018). Beyond the acute phase, the disease could progress into a “pseudo-neurasthenic phase,” characterized by listlessness and personality change, particularly loss of drive (Foley 2018, 411). Moreover, children could develop a persistent change of character as a result of the condition. Also, bradyphrenia (slowness of mental function), memory impairment, depression, nervousness, and fatigue occurred relatively frequently in the chronic phase of encephalitis lethargica (Delgado 1993; Foley 2018).