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Alice in Wonderland Syndrome
Published in Alexander R. Toftness, Incredible Consequences of Brain Injury, 2023
Alice in Wonderland syndrome is an unsettling experience of distortions due to events in your brain. More specifically, Alice in Wonderland syndrome refers to a collection of over 60 different distortions, of which a person will experience one or more (Blom et al., 2021).
Epstein–Barr virus and the nervous system
Published in Avindra Nath, Joseph R. Berger, Clinical Neurovirology, 2020
Alexandros C. Tselis, Kumar Rajamani, Pratik Bhattacharya
There is no treatment for Alice in Wonderland syndrome. Most cases in the literature address the underlying condition. Specifically, antipsychotic medications are not believed to help. The outcome is generally benign. Most patients with follow-up data have recovered completely after a variable period of time, usually within weeks [86]. The underlying pathophysiological mechanism is believed to be functional and structural aberrations of the central visual perceptual system [87].
Case 43: Feels like the room is changing shape
Published in Barry Wright, Subodh Dave, Nisha Dogra, 100 Cases in Psychiatry, 2017
Barry Wright, Subodh Dave, Nisha Dogra
In Alice in Wonderland syndrome knowing the diagnosis is a great help to patients as it reassures them that they do not have a severe mental illness and that they do not have epilepsy. Prevention may be helped by recognizing particular triggers such as tiredness or diet, and making lifestyle changes accordingly. Rarely, other triggers have been reported such as physical exercise or bright lights.
Neuro-Ophthalmic Literature Review
Published in Neuro-Ophthalmology, 2023
David A. Bellows, Noel C.Y. Chan, John J. Chen, Hui-Chen Cheng, Peter W MacIntosh, Collin McClelland, Michael S. Vaphiades, Konrad P. Weber, Xiaojun Zhang
Alice in Wonderland syndrome (AIWS) is a rare neurological disorder characterised by an erroneous perception of the body schema or surrounding space. It may be caused by a variety of neurological disorders, but to date, there is no agreement on which brain areas are affected. The authors conducted a literature search for AIWS cases following brain lesions. Patients were classified according to their symptoms as type A (somaesthetic), type B (visual), or type C (somaesthetic and visual). Using a lesion mapping approach, lesions were mapped onto a standard brain template and sites of overlap were identified. Of 30 lesions detected, maximum spatial overlap was present in six cases. Local maxima were identified in the right occipital lobe, specifically in the extra-striate visual cortices and white matter tracts, including the ventral occipital fasciculus, optic tract, and inferior fronto-occipital fasciculus. Overlap was primarily due to type B patients (the most prevalent type, n = 22), who shared an occipital site of brain damage. Type A (n = 5) and C patients (n = 3) were rarer, with lesions disparately located in the right hemisphere (thalamus, insula, frontal lobe, hippocampal/parahippocampal cortex). The authors concluded that lesion-associated AIWS in type B patients could be related to brain damage in visual pathways located preferentially, but not exclusively, in the right hemisphere. Conversely, the lesion location disparity in cases with somaesthetic symptoms suggests underlying structural/functional disconnections requiring further evaluation.
Introduction to the Special Issue on Rare and Unusual Syndromes
Published in Neuropsychological Rehabilitation, 2018
Michael Perdices, Barbara A. Wilson
The paper on “The Alice in Wonderland Syndrome” (pp. 189–198) describes the case of Zoe, who had the most frequently occurring form of the syndrome, primarily characterised by extra-personal visual illusions (metamorphopsia). The Alice in Wonderland Syndrome is a condition with a well-documented phenomenology in terms of its characteristic visuo-perceptual and visuospatial hallucinations and psychiatric symptomatology. The neuropsychological concomitants have not, however, been previously reported. Indeed, whether or not the profile of cognitive dysfunction of the woman presented in this paper is typical or one of a range of possible neuropsychological manifestations of the syndrome remains unclear.
Neurovisual Manifestations in Children with Mild COVID-19: An Association to Remember
Published in Neuro-Ophthalmology, 2023
Giorgio Costagliola, Michele Pio Vallario, Andrea Santangelo, Thomas Foiadelli, Maria Cristina Ragone, Roberta Battini, Francesca Tinelli, Maria Elisa Di Cicco, Alice Bonuccelli, Giovanni Gaeta, Chiara Iozzi, Diego Giampiero Peroni, Francesca Felicia Operto, Rita Consolini, Alessandro Orsini
Of note, Case 3 is presented with symptoms recalling the clinical picture known as Alice in Wonderland syndrome (AIWS),11 which presents with aschematia and dysmetropsia and has been mainly linked to migraine and different infectious diseases, mostly Epstein–Barr virus (EBV).12 However, differently from AIWS, serological testing performed in Case 3 did not reveal signs of previous EBV infection. To our knowledge, this is the first reported case of AIWS associated with SARS-CoV-2 infection.