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Microneedling
Published in Rubina Alves, Ramon Grimalt, Techniques in the Evaluation and Management of Hair Diseases, 2021
Rachita S. Dhurat, Sanober Burzin Daruwalla
Wound contraction starts soon after dermal tissue injury and peaks in the 2 weeks after the initial insult [10]. As an event during granulation tissue formation, fibroblasts begin to transform into myofibroblast phenotypes that play a major role in wound contraction. These cells play the main role in wound contraction. Wound contraction markedly promotes wound closure. IL-4 induces matrix synthesis after promoting fibroblast differentiation [12]. Wound contraction markedly promotes wound closure.
Animal Models for Studying Soft Tissue Biocompatibility of Biomaterials
Published in Yuehuei H. An, Richard J. Friedman, Animal Models in Orthopaedic Research, 2020
At approximately the third day, formation of collagen fibres by the fibroblasts becomes histologically visible.22 In addition, a network of capillaries is formed to provide oxygen to support the fibroblast synthesis of collagen. In front of the newly formed collagen matrix, the macrophages still continue to phagocytize the dead material hereby creating an environment for other fibroblasts to settle. This process continues until the wound is completely closed. The tissue formed is called granulation tissue. Already at the sixth day of wound healing, maturation of the collagen fibres starts. By means of collagen synthesis and lysis, remodelling of the collagen network occurs. Meanwhile, myofibroblasts are responsible for wound contraction, hereby reducing the wound surface. Finally, the number of cells will decrease, leaving scar tissue behind. The functional characteristics of this newly formed tissue are less effective compared to the original tissue, The wound strength will never reach its original value and scar tissue is nonelastic.22-24
Actions of Dopamine on the Skin and the Skeleton
Published in Nira Ben-Jonathan, Dopamine, 2020
Wound contraction and remodeling: myofibroblasts decrease the size of the wound by gripping the wound edges and contracting, acting like smooth muscle cells. Collagen is then realigned along tension lines, and cells that are no longer needed are removed by apoptosis. Freshly healed epidermis and dermis are formed by the appropriate cells.
Design and fabrication of Sesamol-loaded transfersomal gel for wound healing: physicochemical characterization and in-vivo evaluation
Published in Drug Development and Industrial Pharmacy, 2023
Nida Umam, Mohammad Ahmad, Poonam Kushwaha
Animals were primarily anesthetized with diethyl ether. Following anesthesia, the dorsal backs of the mice were shaved to remove their hair. An antiseptic solution (70% ethanol) was used on the shaved area before creating the wound. An excision wound was created by removing an area of skin of 10 mm diameter (circular area) from a predetermined shaved area on the animal’s back. The wound was left uncovered and no antimicrobial agent was used either locally or systemically. The mice were placed in separate cages. Afterwards, the animals were randomly divided into three groups of five (n = 5) and were caged separately. Group 1 was left untreated (control group), group 2 received transfersomal gel, and group 3 received standard marketed gel. Megaheal gel containing colloidal silver was used as the standard marketed preparation. From the day of the excision wound creation onward, all preparations were applied topically daily to the excision wound area. Wounds were left exposed to air and their healing ratios were measured on days 0, 7, 14, and 21 of the experiment. As with previous studies [18–20] complete wound healing was considered as a percentage of wound contraction and epithelialization time [18–20].Wound contraction
Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing
Published in Drug Delivery, 2022
Mohammed Monirul Islam, Varshini HR, Penmetsa Durga Bhavani, Prakash S. Goudanavar, N. Raghavendra Naveen, B. Ramesh, Santosh Fattepur, Predeepkumar Narayanappa Shiroorkar, Mohammed Habeebuddin, Girish Meravanige, Mallikarjun Telsang, Nagaraja Sreeharsha
In addition, the size of wounds treated with an extract containing nanofibers was reduced. By day 14, the percentage of wounds treated with NS-NF and MS-NS-NF was found to be 89.64% and 96.08%, respectively, compared to 56.84% of wound healing in the control group. Wound contraction occurs throughout the healing phase owing to the proliferation of fibroblasts induced by contractile myofibroblasts. In accordance with the findings of the release and anti-bacterial tests, the proportion of wounds that healed in MS-NS-NF samples was found to be quite similar. Sustaining medication release after a successful first burst release is extremely desirable for the treatment of both the original and most recent wound infection (Rath et al., 2016b). On day 7, some inflammatory responses were reported for gauze-treated lesions. Blood vessels and granulation tissues were seen in the wounds treated with MS-NS-NF. Also evident was the development of fibroblast cells.
Chitosan-biotin topical film: preparation and evaluation of burn wound healing activity
Published in Pharmaceutical Development and Technology, 2022
Faisal Al-Akayleh, Nisrein Jaber, Mayyas Al-Remawi, Ghazi Al Odwan, Nidal Qinna
Based on the results of film morphology and higher BIO release amounts, F4 was selected for the wound healing test. Figure 6 indicates the skin contraction (%) with time for CS, CS/BIO (F4), and control. Wound contraction is an important parameter used to assess wound healing. Groups of animals that received CS and CS/BIO showed significant wound contraction at all time intervals compared to the control group (p < 0.05). Upon comparing CS with CS/BIO composite film, in the beginning, CS showed a higher percentage of contraction until the sixth day of treatment, and then CS/BIO-treated wounds showed higher contraction after the ninth day of treatment. CS film could initially form a moist gel on the wound's surface due to its relatively high-water solubility, while CS/BIO film dissolves slowly. Moist wounds showed a much faster healing rate than the less moist wounds (Svensjö et al. 2000).