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Miscellaneous Causes Of Unexplained Fever
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
Two serous membranes can be affected: mainly synovitis: symptoms vary from joint pain to true arthritis, sometimes associated with myalgia; the large joints are preferentially involved (wrists, ankles, knees . . . ); as for cutaneous manifestations, they are asymmetric and transient and follow a capricious course. Eight cases of recurrent pericarditis have been reported.16 Pleurisy and peritonitis are rare.
Cardiovascular System and Muscle
Published in George W. Casarett, Radiation Histopathology: Volume II, 2019
The epicardium, the thin outer layer of the heart, is analogous to the outer or adven-tial layer of the blood vessel walls and is composed of a single layer of mesothelial cells covering the free surface and resting on a thin layer of connective tissue containing networks of elastic fibers, many nervous elements, and blood vessels. The epicardium is essentially the visceral layer of the pericardium. The parietal layer of the pericardium is a serous membrane, composed of a thin layer of connective tissue covered by a simple layer of mesothelial cells.
Introduction
Published in Shayne C. Gad, Toxicology of the Gastrointestinal Tract, 2018
The serosa is the superficial layer of those portions of the GI tract that are suspended in the abdominopelvic cavity. It is a serous membrane composed of areolar connective tissue and simple squamous epithelium. As we will see shortly, the esophagus, which passes through the mediastinum, has a superficial layer called the adventitia composed of areolar connective tissue. Inferior to the diaphragm, the serosa is also called the visceral peritoneum; it forms a portion of the peritoneum, which we examine in detail next.
Proteomic study of mesothelial and endothelial cross-talk: key lessons
Published in Expert Review of Proteomics, 2022
Juan Manuel Sacnun, Rebecca Herzog, Klaus Kratochwill
There is a plethora of proteomic studies investigating EC and even some secretome studies in combination with other cell types that could potentially be used to extrapolate effects on MC [121–123]. MC research, however, seems to be the limiting factor for discussing crosstalk between these two cell types. In the past, ECs were thought to be a relatively simple cell layer with barrier and transport function separating the systemic circulation from tissue, though today we understand the endothelium as a more complex system with a vast amount of different functions [20]. The same is true for the peritoneum, an organ long thought to have few functions but providing a surfactant cover for the inner organs of the abdominal cavity. Over the last years, this notion has changed, as it became increasingly clear that it is more complex than a simple serous membrane [3]. MCs are, for example, crucial for kidney replacement therapy with peritoneal dialysis, a therapy where – even though the endothelial cells are never in direct contact with the PD fluid – the submesothelial vasculature gets significantly more damaged than expected by uremia alone [124,125]. This vascular damage, in turn, may be the culprit for the increased prevalence of cardiovascular disease in patients on kidney replacement therapy, eventually resulting in increased mortality. This highlights the clinical relevance of this knowledge gap and the need of adequate research. The mesothelium is in contact with both microvascular and lymphatic vessels [126].
The diagnostic and clinicopathological value of trefoil factor 3 in patients with gastric cancer: a systematic review and meta-analysis
Published in Biomarkers, 2021
Chen-Xing Zhang, Chu-Tian Wu, Lin Xiao, Shao-Hui Tang
In this study, the pooled sensitivity, specificity, and AUC of diagnostic indexes for TFF3 in GC were 0.71, 0.80 and 0.80. The above data indicated that TFF3 is a diagnostic biomarker with moderate accuracy for GC. Subsequently, we analyzed the primary source of heterogeneity by dividing these studies into two subgroups, but significant heterogeneity still existed. We speculated that there might be other kinds of heterogeneity like age, gender, cut-off value, etc. On the other hand, we analyzed the relationship of TFF3 expression with the clinicopathological characteristics of GC patients, including lymph node metastasis, depth of tumour invasion, venous invasion, peritoneal metastasis, TNM stage, and histological type. We found that TFF3 expression might be associated with the occurrences of lymph node metastasis, muscularis propria invasion (≥T2), worse TNM stage, and histological type. However, there is no apparent correlation in the aspect of the serous membrane invasion (T4) , venous invasion, and peritoneal metastasis. Our findings demonstrated that TFF3 expression correlated with the above clinicopathological characteristics, which indicates that TFF3 may be an adverse factor in GC progression and metastasis.
Controversies in classification of peritoneal tuberculosis and a proposal for clinico-radiological classification
Published in Expert Review of Anti-infective Therapy, 2019
Rizwan Ahamed Z, Jimil Shah, Roshan Agarwala, Praveen Kumar-M, Harshal S Mandavdhare, Pankaj Gupta, Harjeet Singh, Aman Sharma, Usha Dutta, Vishal Sharma
The peritoneum is the largest serous membrane in the body and protects the abdominal cavity and the visceral organs. It also forms the omentum and the mesentery which enclose the small intestine. Peritoneal involvement by TB is well recognized and can occur in isolation or in combination with other intra-abdominal or extra-abdominal organs. Indeed, in one of the reports on peritoneal TB, 65% of the cases were associated with tubercular involvement at other sites[5]. Peritoneal TB has been reported to occur in up to 3.5% of the cases of pulmonary TB, and comprises 31–58% of cases of abdominal TB [6,7]. The reported incidence of peritoneal TB as a cause of ascites is only 2%; however, in a series from North India, TB was the second most common cause of ascites after cirrhosis [8,9]. It can also have significant overlap with intestinal TB, another common form of abdominal TB. In a recent report, 18 (16%) of all patients with abdominal TB had a combined involvement of the gastrointestinal lumen and the peritoneum [10].