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Epigenetics and Assisted Reproduction Experimental Studies
Published in Cristina Camprubí, Joan Blanco, Epigenetics and Assisted Reproduction, 2018
Joan Blanco, Cristina Camprubí
Paternal age could be another factor that increase the possibility of alterations. Actually, the negative influence of age on the testicular function and seminogram is well documented (25). Some authors have found a widespread increase of sperm DNA methylation with age (26). This age effect over sperm methylation could uncover the methylation marks of groups of genes associated with fertility. For instance, in semen samples collected in the range of 9–19 years apart, it has been described a set of genes with significant changes over time (27). In this sense, Camprubí et al. (2016) supports the association between advanced age and sperm RPS6KA2 hypermethylation (9). This gene encodes a member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases implicated in controlling cell growth. Actually, the influence of age over DNA methylation goes beyond male fertility. It has been described that DNA from blood of old individuals is more heterogeneous and hypomethylated in comparison with newborn DNA (28). Moreover, premature aging diseases has been also related with variations in blood DNA methylation at specific loci (29).
Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses
Published in Hematology, 2023
Shasha Wu, Jiao Jin, Jing Huang, Guifang Chen, Yan Chen
The RSK family comprises four human isoforms (RPS6KA1, RPS6KA2, RPS6KA3, and RPS6KA6) and two structurally related homologues (RSP6KA4 and RSP6KA5). RSK gene family members share a high degree of sequence homology (75–80% amino-acid identity) and are uniquely characterized by the presence of two distinct functional kinase domains [12,13].