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Translation and Post-Translational Modifications During Aging
Published in Alvaro Macieira-Coelho, Molecular Basis of Aging, 2017
In addition to the types of posttranslational modification mentioned above, there are some other modifications that determine the structure and function of various proteins and may have a role to play during aging. For example, the incorporation of ethanolamine into protein elongation factor EF-1α may be involved in determining its stability and interaction with intracellular membranes.51 Whether this modification has any role in the regulation of the activity of EF-1α is not known at present. Similarly, the protein initiation factor eIF-5A contains an unusual amino acid, hypusine, which is synthesized posttranslationally as a result of a series of enzymically catalyzed alterations of a lysine residue.166 Since the absence of hypusine in eIF-5A blocks the initiation of protein synthesis,166 it will be interesting to investigate changes in this modification during aging when total protein synthesis slows down.
Identification and validation of Sertoli cell homing peptides as molecular steering for testis targeted drug delivery
Published in Journal of Drug Targeting, 2023
Yugandhara Jirwankar, Vikas Dighe
Motif discovery analysis of common 1551 peptide sequences using STREME (Sensitive, Thorough, Rapid, Enriched Motif Elicitation) [39] (https://doi.org/10.1093/bioinformatics/btab203) resulted in six enriched ungapped motifs with p-value <0.05. GSAK motif is enriched in 203 (13.1%) sequences followed by FRAQPTI, YSLRLT, SVTAPT, RDTH, and MKA (Figure 5 A–F), a summary of their p-values, E-values, and sites are shown in Supplementary Table 2. Further, these motifs were submitted to Tomtom, a motif comparison tool (https://doi.org/10.1186/gb-2007-8-2-r24) [40] which compared the submitted protein motif with motifs on the prosite database. Out of six enriched motifs, only GSAK and YSLRLT resulted in one hit each with E value <0.1. The motif similarity of GSAK and YSLRLT was found with Eukaryotic initiation factor 5 A hypusine signature (PS00302) and Stress-induced proteins SRP1/TIP1 family signature (PS00724), respectively (Supplementary Figure 3). Though the E-value for these two alignments is <0.1, these motifs are not 100% similar to their hits, indicating the novelty of the discovered motifs. Seqlogo analysis of common 1551 peptides with TBtool (Figure 5G) revealed GSWNTFRAQ and PTI as enriched domains, which is the actual sequence of the SCHP1 peptide.