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Translation and Post-Translational Modifications During Aging
Published in Alvaro Macieira-Coelho, Molecular Basis of Aging, 2017
In addition to the types of posttranslational modification mentioned above, there are some other modifications that determine the structure and function of various proteins and may have a role to play during aging. For example, the incorporation of ethanolamine into protein elongation factor EF-1α may be involved in determining its stability and interaction with intracellular membranes.51 Whether this modification has any role in the regulation of the activity of EF-1α is not known at present. Similarly, the protein initiation factor eIF-5A contains an unusual amino acid, hypusine, which is synthesized posttranslationally as a result of a series of enzymically catalyzed alterations of a lysine residue.166 Since the absence of hypusine in eIF-5A blocks the initiation of protein synthesis,166 it will be interesting to investigate changes in this modification during aging when total protein synthesis slows down.
Fe3O4 Nanopowders: Genomic and Apoptotic Evaluations on A549 Lung Adenocarcinoma Cell Line
Published in Nutrition and Cancer, 2020
Ayse Kaplan, Hatice Mehtap Kutlu, Gulsen Akalin Ciftci
The down regulation of SRC gene has been shown as a new strategy in the treatment of solid tumors (53). In our work, this gene was downregulated by IC30 value of Fe3O4 nanopowders and we think that the downregulation of this gene induce apoptosis in A549 cells. The HRAS gene has been overexpression in various types of cancer (54,55). The CDC34 gene has been also overexpression in MM (multiple myeloma) cells (56). In addition, EIF4G1 gene has been over expressed in nasopharyngeal carcinoma cells (57). The EIF5A gene has been overexpressed in HCC (hepatocellular carcinoma), ovarian cancer and lung cancer (58). As a result, these genes have been shown as therapeutic markers. In our work, these genes were downregulated by IC30 value of Fe3O4 nanopowders and can be effective on apoptotic pathways. The EIF2C2, ANG and NUCKS1 genes were downregulated by IC50 value of cisplatin and IC30 value of Fe3O4 nanopowders in A549 cells. These findings show that Fe3O4 nanopowders may affect same apoptotic pathway such as cisplatin.