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Magnetic Nanoparticles for Hyperthermia against Cancer
Published in D. Sakthi Kumar, Aswathy Ravindran Girija, Bionanotechnology in Cancer, 2023
Sivakumar Balasubramanian, Allison J. Cowin
The term “hyperthermia” means the generation of heat and in literature is limited to the application of heat for therapeutic applications. Hyperthermia has been used alongside various cancer therapies such as chemotherapy, radiation therapy, immuno-therapy, gene therapy, and surgery. Hyperthermia is a normal or simulated process that raises the temperature of a body or body part, over threshold temperature set at a specific moment by thermoregulation pattern of an organism [1, 2]. When considering cancer therapies, hyperthermia is the artificial method of gradually raising body temperature by heat acquired from external sources to kill cancer cells or preventing the spread of cancer.
Transpupillary thermotherapy of choroidal neovascularization
Published in A Peyman MD Gholam, A Meffert MD Stephen, D Conway MD FACS Mandi, Chiasson Trisha, Vitreoretinal Surgical Techniques, 2019
Hyperthermia treatment can be applied as either systemic hyperthermia or localized heating. In TTT, the difficulty of delivering hyperthermia to the target tissue is obviated, as the anatomy of the eye allows direct access to the posterior segment structures. Thermometry measurements in ocular hyperthermia are invasive and impractical and are not performed. In contrast to cancer treatments, in which complete tumor destruction to the last viable cell is required for treatment success, the success in TTT for CNV requires only the occlusion of neovascular vessels, making thermometry readings less important.
Hyperthermia of Liver
Published in Leopold J. Anghileri, Jacques Robert, Hyperthermia in Cancer Treatment, 2019
Joseph L. Skibba, Edward J. Quebbeman
The renewed interest in hyperthermia as a treatment for cancer has heightened the awareness of investigators that normal tissues respond to the effects of heat in a differential manner. Moreover, the toxic effects of heat depend on the actual level of temperature, the length of time at that temperature, and other factors such as tissue pH and nutritional state. Because the objective of hyperthermic therapy is to cause death of cancer cells with little or no adverse effects on normal tissues, the thermal threshold for irreversible damage to normal tissue becomes important. The effects of heat on the liver became important to these investigators as we developed a technique of isolation-perfusion of the canine and human liver as a means of eradicating cancer in the liver.1–3
Efficacy and safety of intraperitoneal bevacizumab combined with hyperthermic intraperitoneal chemotherapy in the treatment of patients with ovarian cancer and peritoneal effusion and the effect on serum lncRNA H19 and VEGF levels
Published in Journal of Obstetrics and Gynaecology, 2023
Meiling Zhang, Yu Bao, Hong Zhang, Dongmei Li, Xinkuan Mei, Xianping Cheng
Bevacizumab is a recombinant humanised monoclonal antibody that has been approved for first-line maintenance therapy in advanced OC (Mao et al.2022). The application of bevacizumab in standard front-line cytotoxic chemotherapy leads to an approximately 3-4-month elevation in progression-free survival (Haunschild and Tewari 2020). Bevacizumab possesses the ability to improve the survival of OC patients (Li et al.2021) and reduces the expression levels of cancer-related markers more than chemotherapy alone (Ma 2022). The hard-done work of our peers has highlighted the curative effect of IV bevacizumab combined with various chemotherapeutic agents for the treatment of ovarian peritoneal malignancy/ascites (Lemoine et al.2017). Hyperthermic intraperitoneal chemotherapy (HIPEC), comprising induction of hyperthermia as well as delivery of chemotherapeutic drugs into the peritoneal cavity, is an emerging treatment for patients with peritoneal cancer, including epithelial OC (Gadducci et al.2022). There is evidence to indicate that hyperthermia can enhance the penetration of chemotherapeutic agents at the peritoneal surface and elevate the chemosensitivity of cancer cells by impairing DNA repair, which is also shown to activate the heat-shock proteins that act as vital receptors for natural killer cells, trigger apoptosis, suppress angiogenesis, and confer direct cytotoxic effects through promotion of protein denaturation (van Driel et al.2018). Therefore, we analysed the efficacy of intraperitoneal bevacizumab combined with HIPEC in treating peritoneal effusion in OC patients.
Beyond heat exposure — new methods to quantify and link personal heat exposure, stress, and strain in diverse populations and climates: The journal Temperature toolbox
Published in Temperature, 2023
Gisel Guzman-Echavarria, Ariane Middel, Jennifer Vanos
Physiologically, the thermoregulatory system balances the internal heat production and external environmental heat fluxes to maintain a stable internal temperature [1,11,12]. However, the body may or may not compensate during heat stress to return to thermal equilibrium (Figure 1). Compensable heat stress (CHS) occurs when heat loss to the environment is balanced with heat gain; hence, a steady-state core temperature can be sustained [13]. Conversely, uncompensable heat stress (UHS) occurs when evaporative cooling requirements are not supported due to environmental or other conditions (including low sweat production) that impede the body’s ability to cool [13]. In UHS, the internal body temperature rises, which can result in hyperthermia. Generally, hyperthermia is divided by degree of severity into heat cramps, heat exhaustion, and potentially fatal heatstroke, either classic or exertional [1].
Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia
Published in International Journal of Hyperthermia, 2022
Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Kiyoshi Miyagawa
Hyperthermia is a well-known method for cancer treatment and is often used in combination with radiotherapy or chemotherapy. Hyperthermia increases the cell temperature and induces many biochemical changes, such as the generation of reactive oxygen species, an increased intracellular calcium ion concentration and protein degradation [1,2]. Hyperthermia-induced protein denaturation, aggregation, or degradation is a key event in the disruption of cellular homeostasis [3,4]. Intracellular protein degradation is regulated by multiple proteolytic pathways, including lysosome-, calcium- and proteasome-dependent mechanisms [5,6]. Hyperthermia induces the proteasomal degradation of anti-apoptotic regulators and DNA repair proteins [7,8]. However, the molecular mechanisms underlying thermal protein degradation and their roles in thermal killing are largely unknown.