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Structure and function of skin
Published in Roger L. McMullen, Antioxidants and the Skin, 2018
The elastic fibers can be categorized into a fibrillar component (fibrillin) as well as an amorphous component (elastin). Elastic fibers are further classified as: (1) oxytalan fibers—fibers that are lightly coated with elastin; and (2) elaunin fibers—fibers more heavily coated with elastin.
Collector Channels: Role and Evaluation in Schlemm’s Canal Surgery
Published in Current Eye Research, 2020
Abdelrahman M. Elhusseiny, Emery C. Jamerson, Rahma Menshawey, Emily K. Tam, Yasmine M. El Sayed
CCs are openings that originate in the outer wall of SC that function as conduits, connecting SC to the EVs.9 The walls and orifices of the collector channels are rich in elastin, elaunin, and oxytalan fibers that provide structural support and flexibility for the outflow system, allowing these channels to withstand the biomechanical stress occurring due to IOP and eye movements.12 After staining serial sections of normal human eyes with Weigert’s resorcin-fuchsin stain with oxidation, Hann and colleagues using immunohistochemistry techniques investigated the elastic fiber system in the juxtacanalicular tissue adjacent to CC.12 It is a novel technology that helps to elucidate constituent properties of the outflow system. CC orifices are tubular/oval in shape with sieve-like coverings, varying in opening size from 10 to 100 μm with CC volumes ranging between 10 and 70 μm.4,13,14 CCs range in number from 24 to 35 per eye and are pseudo-sporadically dispersed with a tendency toward higher distribution in the inferior-nasal portion of the eye.15 There are variations among eyes, especially in primary open angle glaucoma (POAG), which are noted to have increased number of CCs in the setting of elevated IOP.16 Outflow facility through the orifices has been noted to be inversely proportional to IOP, attributed, in part, to ostium obstructions by partial or complete herniations in the setting of increased IOP. Taken together, these findings suggest that the increased number of CCs seen in POAG may exist as a result of compensatory upregulation of CC density due to decreased aqueous humor outflow within individual CCs in the setting of CC ostium obstructions.16