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Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease
Published in Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Debasis Bagchi, Psoriasis and Psoriatic Arthritis, 2017
Asmita Hazra, Saptarshi Mandal
Chemerin belongs to adipokines, that is, adipose tissue–derived cytokines, which also happen to include molecules as famous as TNFα and IL6. As already discussed, chemerin is the strongest candidate for the pDC recruitment chemoattractant in psoriasis, and like many other adipokines, it is also directly pro-angiogenic.
Circulating chemerin levels in women with polycystic ovary syndrome: a meta-analysis
Published in Gynecological Endocrinology, 2022
Xin Wang, Qi Zhang, Lin Zhang, Wenjing Wei, Leliang Liu, Beibei Li, Liao Zhang, Ying Zhang, Yuyu Hui, Ye Lei
Chemerin, encoded by the gene retinoic acid receptor responder 2 (Rarres2) or tazarotene-induced gene 2 (TIG2), is a newly discovered adipokine involved in inflammation, adipogenesis, angiogenesis, and energy metabolism [3,7]. Bongrani et al. reported that the chemerin level is higher in both follicular fluid and ovarian granulosa cells than in the plasma of women with PCOS and has a positive correlation with body mass index (BMI) [8]. The expression of chemerin is upregulated by testosterone in the follicular fluid. Additionally, high chemerin levels have been reported to be associated with poor in vitro fertilization (IVF) outcomes and abortion in patients with PCOS [9,10]. Elevated chemerin levels induce IR in patients with PCOS [11]. Some studies have also reported that circulating chemerin levels are positively correlated with obesity and IR [12,13]. Moreover, a study reported that serum chemerin levels are associated with gestational diabetes mellitus, type 2 diabetes mellitus (T2DM), hypertension, and obesity [7,14]. Additionally, in vitro studies have demonstrated that chemerin stimulates the progression of atherosclerosis [15].
Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level
Published in Renal Failure, 2018
Hamid Nomani, Hamid Khanmohamadian, Asad Vaisi-Raygani, Ebrahim Shakiba, Maryam Tanhapour, Zohreh Rahimi
The high serum chemerin concentration in ESRD patients decreased to the values observed in healthy subjects after kidney transplantation [39]. Chemerin is expressed at high levels on immune cells and macrophages. Moreover, it acts as a chemotactic agent through its binding to chemerin receptor [11]. In humans, plasma chemerin concentrations are correlated with body mass index (BMI), glucose and lipid metabolism [7,16]. There are some evidences to suggest that chemerin is also expressed in animal kidneys [8]. Recently, the association between chemerin levels and obesity has been examined in hemodialyzed patients [40]. Studies on hemodialysis patients demonstrated that markers of kidney function are independently associated with plasma chemerin concentrations [41]. In the study performed by Blaszak et al., 70% higher chemerin concentration was observed in chronic kidney disease (CKD) patients compared to the control group (p < .001) and also elevated serum chemerin concentration in CKD patients was correlated to kidney function and hemodialysis treatment [16]. In addition, previous studies demonstrated that the high level of serum chemerin in CKD patients decreased to normal range after kidney transplantation [16,42]. A review study showed that the racial and ethnic differences have a straight and direct correlation with renal failure [43].
Relationship of circulating chemerin and omentin levels with Th17 and Th9 cell immune responses in patients with asthma
Published in Journal of Asthma, 2018
Qing Zhou, Yu Fu, Liangan Hu, Qian Li, Meng Jin, E. Jiang
Both pro- and anti-inflammatory roles of chemerin and CMKLR1 in immune processes were documented in studies on animal- and cell-based models [7]. A growing body of literature has associated high chemerin levels with inflammation in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis [30], as well as in the serum of patients with chronic pancreatitis [31], chronic obstructive pulmonary disease [32], psoriasis [33] and inflammatory bowel disease (ulcerative colitis and Crohn's disease) [34]. In our study, plasma chemerin levels were elevated in asthmatic patients, but only the severe persistent asthmatics had a statistically significant increase compared to the controls. Thus, chemerin appears to have a role in the systemic inflammatory response. However, Doyle et al. [35] reported that the activation of chemerin receptors decreased allergic airway inflammation in a mouse model of asthma, which was apparent both histologically and by reduced eosinophil counts in bronchoalveolar lavage fluid. The conflicting results on the effects of chemerin may be attributed to varying roles played by chemerin in different phases of inflammation [7].