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Fluorescent Technology in the Assessment of Metabolic Disorders in Diabetes
Published in Andrey V. Dunaev, Valery V. Tuchin, Biomedical Photonics for Diabetes Research, 2023
Elena V. Zharkikh, Viktor V. Dremin, Andrey V. Dunaev
Studies on the noninvasive assessment of other biotissue fluorophores contributing to the diagnosis of disorders occurring in DM, in particular the Krebs cycle coenzymes NADH and FAD, were also reviewed. Finally, the advantages of using fluorescence methods in multimodal optical noninvasive studies in various combinations with other biophotonics methods are evaluated. The results of joint application of fluorescence with laser Doppler flowmetry to improve diagnosis of the presence and severity of microcirculatory and metabolic disorders in DM are presented.
Spectro-Temporal Autofluorescence Contrast–Based Imaging for Brain Tumor Margin Detection and Biobanking
Published in Yu Chen, Babak Kateb, Neurophotonics and Brain Mapping, 2017
Asael Papour, Zach Taylor, Linda Liau, William H. Yong, Oscar Stafsudd, Warren Grundfest
The spectro-temporal autofluorescence system has the ability to create real-time, wide-field contrast images based on relative fluorescence lifetime signatures. This system holds the potential to differentiate and detect tissues in biorepositories (ex vivo) and as an intraoperative device in clinical setting (in vivo). The rapid imaging rate facilitates implementation of FLIM modality in intraoperative setting and can enable cancer margin delineation and accurate scission, to achieve better patient outcome. Those capabilities coupled with modular, low-cost components bring closer the realization of the implementation of this system in a clinical setting. This technology is just one example of new advances in biophotonics that enable scientists, engineers, and clinicians to advance technologies from the bench to the bedside with continuing decrease in complexity and development times.
Energy Medicine
Published in Len Wisneski, The Scientific Basis of Integrative Health, 2017
Photobiology is concerned with the interaction of light with living organisms, from cells to tissues to in vivo live specimens (including human beings). Photochemistry and photophysics deal with the interactions of matter, in general, but most of the knowledge in these fields relates to inanimate matter (Prasad, 2003). Albert Einstein's major discovery in 1905 was in the area of photophysics, with the photoelectric effect paving the way for a revolution in optics that germinated a half-century later with the invention of the laser by Theodore Maiman. The field of biophotonics has progressed to the point that researchers have developed models to explain and demonstrate cell-to-cell communication with photons (Popp et al., 2002).
Combined radiation strategies for novel and enhanced cancer treatment
Published in International Journal of Radiation Biology, 2020
Georgios Kareliotis, Ioanna Tremi, Myrsini Kaitatzi, Eleni Drakaki, Alexandros A. Serafetinides, Mersini Makropoulou, Alexandros G. Georgakilas
Unfortunately, most currently used PSs absorb light mainly in the visible region of the electromagnetic spectrum. Therefore, in an ideal protocol the light used should be IR, and, hence, penetrative, and, at the same time visible, and as a result PS-effective. The parallel use of another modality as upconverting nanoparticles (UCNPs) may be the solution to this puzzle. They were introduced in the past decade in the field of biophotonics, demonstrating high-imaging resolution and relatively large penetration depth in tissues (Soderlund et al. 2015). They form a class of photoluminescent materials, able to emit light with shorter λ than the one absorbed. This procedure, that may involve the sequential absorption of two or more photons, is called photon upconversion (Singh et al. 2019). Hence, UCNPs could be used in PDT to achieve deep lesion treatment, with the conversion of external illuminating IR light to internal illuminating visible, able to activate most photosensitizing agents.
Choroidal Differences between Spectral and Swept-source Domain Technologies
Published in Current Eye Research, 2021
Isabel Pinilla, Ana Sanchez-Cano, Gema Insa, Isabel Bartolomé, Lorena Perdices, Elvira Orduna-Hospital
The imaging depth of the Spectralis (1.9 mm) and the Triton (2.6 mm) and their axial resolution are coupled performance parameters. The depth at which light can penetrate is often limited by the scattering effects of the sample and the optical absorption. The scattering mainly causes that the absorption mechanism to have a low influence on the attenuation coefficient. The scattering coefficient decreases for longer wavelengths in the near-infrared region. Even so, these longer wavelengths are normally chosen to improve the performance of biophotonic devices, as they allow for deeper penetration. These approaches need to be utilized to solve issues like the limitations of the standards of light that can be delivered to the cornea or water absorption.38
Anti-triple-negative breast cancer metastasis efficacy and molecular mechanism of the STING agonist for innate immune pathway
Published in Annals of Medicine, 2023
Xing Lu, Xiang Wang, Hao Cheng, Xiaoqing Wang, Chang Liu, Xiangshi Tan
We created 4T1-Luc cell lines to express firefly luciferase stably, which allowed us to track and quantify cells in vivo. In vivo Biophotonic imaging was used to identify tumour cell spread and proliferation. Mice were weighed and intraperitoneally treated with 150 mg/kg luciferin. After 9 min of luciferin treatment, the animals were pre-anesthetized using an oxygen-isoflurane mixed gas (1%–3%). At 12 min following luciferin administration, the animals were placed into the imaging chamber for bioluminescence measurement assessment using a Xenogen IVIS Lumina XRMS Series III live animal bioluminescence imaging system (Perkin Elmer, USA). On the last day, mice were sacrificed, then their hind limbs and organs were imaged and removed within 10 min.