Archaeol

Archaeol

Archaeosomes for Skin Injuries

Published in Andreia Ascenso, Sandra Simões, Helena Ribeiro, Carrier-Mediated Dermal Delivery, 2017

Monica Vazzana, Joana F. Fangueiro, Caterina Faggio, Antonello Santini, Eliana B. Souto

In contrast to Bacteria and Eukarya, where the unsaturated acyl chains of variable length of the membrane phospholipids are ester-linked to the sn-1,2 position of glycerol-3-phosphate scaffold, the backbone of archaeal lipids consists of methyl branched isoprenoid chains (5-carbon repeating units), which are fully saturated and connected via ether linkages to sn-2,3 carbon of glycerol-1-phosphate [21,22]. Archaeal-type lipids consist of archaeol (diether) (2,3-di-O-diphytanil-snglicerol consisting mainly of C20,20 alkyl chains) and/or caldarchaeol (tetraether) (2,2’,3,3’-tetra-O-dibiphytanil-sndiglycerol with C40,40 carbon chains) core structures [20].

In vitro evaluation of archaeosome vehicles for transdermal vaccine delivery

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Journal Information

Published in Journal of Liposome Research, 2018

Yimei Jia, Michael J. McCluskie, Dongling Zhang, Robert Monette, Umar Iqbal, Maria Moreno, Janelle Sauvageau, Dean Williams, Lise Deschatelets, Zygmunt J. Jakubek, Lakshmi Krishnan

Halobacterium salinarum (ATCC 33170), Haloferax volcanii (ATCC 29605), and Methanobrevibacter smithii ALI (DSM 2375) were grown in 75–250 L fermenters, and the TPL were extracted as described previously (Sprott et al.1999, 2012). Archaeol was purified from Halobacterium salinarum and/or Haloferax volcanii and used as a building block for semi-synthetic glycolipids (Sprott et al.2012).

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Archaeosomes for Skin Injuries

In vitro evaluation of archaeosome vehicles for transdermal vaccine delivery