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Bone Regeneration Effect of Cassia occidentalis Linn. Extract and Its Isolated Compounds
Published in Brijesh Kumar, Vikas Bajpai, Vikaskumar Gond, Subhashis Pal, Naibedya Chattopadhyay, Phytochemistry of Plants of Genus Cassia, 2021
Brijesh Kumar, Vikas Bajpai, Vikaskumar Gond, Subhashis Pal, Naibedya Chattopadhyay
Concerning OA, the chondroprotective effect of quercetin has been assessed. Quercetin protected rat articular chondrocytes from IL-1β-induced loss of cell viability and degradation of matrix proteins including col2 and aggrecan, and glycosaminoglycans. Quercetin also suppressed the levels of IL-1β-induced inflammatory and catabolic mediators in chondrocytes including inducible NO synthase (iNOS), COX2, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4 by inhibiting the Akt and NFκB signaling. Although quercetin had no effect on the expression of M1 phenotype genes (mostly pro-inflammatory), it significantly upregulated the M2 phenotype genes including arginase 1, chitinase 3-like protein 3 and mannose receptor, which suggested that quercetin favours polarization of synovial macrophages into M2 phenotype which in turn provides a prochondrogenic environment required for remodelling of injured cartilage (Hu et al., 2019).
Haematological problems
Published in Catherine Nelson-Piercy, Handbook of Obstetric Medicine, 2020
TTP is associated with deficiency of a specific vWF-cleaving protease (metalloprotease). In non-familial TTP, there is an inhibitor of vWF-cleaving protease (ADAMTS-13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13).In familial TTP, there is a constitutional deficiency of vWF-cleaving protease.
Endocrine causes of recurrent implantation failure
Published in Efstratios M. Kolibianakis, Christos A. Venetis, Recurrent Implantation Failure, 2019
Gesthimani Mintziori, Dimitrios G. Goulis
Animal and human data demonstrate that uterine receptivity in women with PCOS is impaired. Li et al. have demonstrated not only high circulating estrogen in DHEA-induced PCOS mice, but also compromise in the uterine decidualization and changes in the expression of implantation-related genes.49 Women with PCOS show increased endometrial androgen receptor (AR) expression, possibly inducing endometrial abnormalities in women with PCOS.50 Oocyte and embryo quality after IVF is also reported to be compromised in women with PCOS, probably due to increased oxidative stress in granulosa cells.51 Τhe exact mechanism is unknown, but it seems that the NADPH oxidase (NOX) pathway may play a role in reactive oxygen species (ROS) production by granulosa cells in women with PCOS.51 Elevated aggrecan, disintegrin, and metalloproteinase with thrombospondin motif-1 (ADAMTS-1) concentrations were found in the follicular fluid of women with PCOS, indicating a potential role of aggrecan in the pathogenesis of PCOS. A positive predictive effect of ADAMTS-1 on implantation was noted, indicating a potential role as a marker of high-quality embryos in women with PCOS.52
Elevated Expression of ADAMTS-12 in Maternal and Umbilical Cord Serum of Placenta Accreta Spectrum
Published in Fetal and Pediatric Pathology, 2023
A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS) is a family of extracellular matrix (ECM) proteinases comprising 19 secreted proteolytic enzymes that are structurally and functionally associated with matrix metalloproteinases [9]. Along with several other fundamental activities, such as embryonic development, cell migration, and angiogenesis, they are essential for altering the ECM [10,11]. ADAMTS-12, a member of the ADAMTS family, has been linked to the pathophysiology of several illnesses, including cancer, inflammatory conditions, especially arthritic diseases, and atherosclerosis [12]. The pattern of human placenta ADAMTS-12 has relevance to disorders of the gestational trophoblast [13–15]; however, no study is currently available to demonstrate the level of ADAMTS-12 in either the maternal or the umbilical cord of PAS patients. We investigated the maternal and cord blood serum ADAMTS-12 levels in PAS to determine if it is associated with PAS.
The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer
Published in Cancer Investigation, 2023
Qia Zhang, Quist Kanyomse, Chenghao Luo, Qingfan Mo, XunPing Zhao, Long Wang, Weiyan Peng, Guosheng Ren
ADAMTS8 belongs to the Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS) family and is a key antiangiogenic regulatory protein (8). ADAMTS8 inhibits epidermal growth factor receptor (EGFR) signaling and as well as vascular endothelial growth factor (VEGF)-mediated angiogenesis by endothelial cells, leading to decreased expression levels of p-MEK and p-ERK (9). A disintegrin-like and metalloprotease with therombospondin type1motif 8 (ADAMTS8) has structural similarity to a disintegrin-like and metalloprotease with therombospondin type1 motif 1 (ADAMTS1) is an important member of the anti-angiogenic family of the ADAMTS (10). The two molecules differ in that ADAMTS8 has only one C-terminal domain, which is crucial for the suppression of angiogenesis (9). Recently, ADAMTS family proteins have been found to be related to oncogenesis (9), and methylation of another family member, a disintegrin-like and metalloprotease with therombospondin type1 motif 9 (ADAMTS9), is essential for the occurrence and development of breast cancer (9). ADAMTS8 and ADAMTS9 are the two anti-angiogenic members of the ADAMTS family with aggrecanase properties (11–13), which is associated with tumor suppression (12). The ADAMTS8 gene is hypermethylated when associated with tumor growth and metastasis of gastric cancer (14). ADAMTS8 could suppress cell proliferation in hepatocellular carcinoma and esophageal squamous cell carcinoma (15,16). However, the biological role and clinical significance of ADAMTS8 in breast cancer remain poorly defined.
An observational study of pro- and anti-angiogenic factors in hypertensive disorders of pregnancy in women of African ancestry
Published in Journal of Obstetrics and Gynaecology, 2022
Nerolen Soobryan, Ajit Kumar, Jagidesa Moodley, Irene Mackraj
A metabolic protein that has not been well studied is ADAMTS12, a protein affecting insulin-like growth factors and responsible for regulating cytotrophoblast invasion along the invasive pathway, during the first trimester. We found ADAMTS12 was significantly higher in EOPE as compared to GH. ADAMTS-12 plays a vital role in placental adhesion to extracellular matrix as it increases of invasion of the extracellular vesicles. Detection using the ELISA technique revealed consistent results (Kirbas et al. 2016) compared to other detection methods. This finding is novel and further contributes to differentiation factors between EOPE and GH, as proteinuria is no longer a sole determining factor in pre-eclampsia classification. The elevated ADAMTS-12 in EOPE highlights the involvement of extracellular vesicles in its’ pathology whilst absolving them in the pathogenesis of GH.