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Animal Handling, Drug Administration, Dissection, and Tissue and Fluid Sampling Techniques
Published in Howard J. Glenn, Lelio G. Colombetti, Biologic Applications of Radiotracers, 2019
Muhammad R. Atallah, Howard J. Glenn
Intramuscular injections are usually made into fairly large muscles such as the thigh muscle. No bone should be encountered nor blood vessel penetrated. With the syringe in place and prior to injection, the syringe plunger should be withdrawn slightly to make sure that there is no blood return.
Formulary
Published in Sarah Bekaert, Alison White, Integrated Contraceptive and Sexual Healthcare, 2018
Sarah Bekaert, Alison White, Kathy French, Kevin Miles
Pain or discomfort may be experienced at the site of intramuscular injection immediately after administration but is usually well tolerated and transient. Local phlebitis has occurred rarely following intravenous administration but can be minimised by slow injection over at least 2-4 minutes.
Orthomolecular Parenteral Nutrition Therapy
Published in Aruna Bakhru, Nutrition and Integrative Medicine, 2018
Arturo O'Byrne-Navia, Arturo O'Byrne-De Valdenebro
Some adverse reactions with intramuscular injection are related to the nature of the drug itself. It is widely known how vitamin B1 and B complex vitamins produce much more pain when injected through this route. This fact can be reduced in some degree when these types of orthomoleculars are injected deeply into the gluteal muscle.
An evaluation of long-acting cabotegravir + rilpivirine for the treatment of virologically suppressed adults living with HIV
Published in Expert Opinion on Pharmacotherapy, 2022
Hamdi Qazzaz, Christopher Parganas, Theodore James Cory
Although long-acting injectable medications can improve patient adherence by extending dosing intervals, there are potential drawbacks to restrictive administration that include additional costs for patients, travel burden, and continued lack of adherence. Intramuscular injection therapy is only effective if the patient is determined to meet monthly dosing appointments. In patients who have a lack of adherence to oral medications, the addition of a once monthly injection could introduce therapeutic treatment failure, due to not meeting monthly appointments, further reducing the effectiveness of their medication regimen. Travel burden is also a significant issue faced for patients who cannot afford monthly commutes to clinician offices. This has significant impacts on the adherence of a monthly medication, which would further exacerbate treatment failures. Further, currently the drug is very expensive, particularly in comparison to highly effective oral medications.
Sublingual methylcobalamin treatment is as effective as intramuscular and peroral cyanocobalamin in children age 0–3 years
Published in Hematology, 2021
Betül Orhan Kiliç, Serhat Kiliç, Elif Şahin Eroğlu, Eylem Gül, Fatma Burcu Belen Apak
The standard vitamin B12 treatment that has been known and applied for years is the parenteral vitamin B12 treatment. As a result of the studies in the world and our country over the years, it has been shown that oral vitamin B12 treatment is as effective as intramuscular therapy in adults[4–7]. Intramuscular injections are painful and prone to complications, and at the same time, they need to be applied at the hospital, so recently oral administration is preferred more frequently[4]. Therefore, oral vitamin B12 treatment, which is painless and easily applied is recently been used in children. In some studies, it was shown that oral cyanocobalamin therapy in children as was as effective as intramuscular treatment[8,9]. Although the effectiveness of sublingual therapy in adults has been demonstrated, limited studies are showing the efficacy of sublingual methylcobalamin therapy in children, which is easier to apply than oral cyanocobalamin therapy [10,11].
Efficacy of combined treatment of intramuscular testosterone injection and testosterone ointment application for late-onset hypogonadism: an open-labeled, randomized, crossover study
Published in The Aging Male, 2020
Tsukasa Narukawa, Jintetsu Soh, Noriyuki Kanemitsu, Shunji Harikai, Osamu Ukimura
An additional and important consideration when determining treatment methods is the adverse effect of TRT [15]. In this study, 2 of 52 participants were not able to continue the study due to the experience of adverse effects from the intramuscular injections of testosterone (palpitations) or GL (gynecomastia). With regard to the biochemical tests, there were no adverse effects that interrupted the study; however, during the IMIM phase, the hemoglobin and hematocrit levels were higher than during the CT phase. Patients with hemoglobin or hematocrit levels elevated to polycythemic levels (hemoglobin ≥18 g/dL or hematocrit ≥53%) from the intramuscular testosterone injection may benefit from TRT using CT. Furthermore, the pain caused by intramuscular injections may be an important consideration.