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Atherosclerosis
Published in George Feuer, Felix A. de la Iglesia, Molecular Biochemistry of Human Disease, 2020
George Feuer, Felix A. de la Iglesia
One of the most widely studied compounds is triparanol (4-chloro-α-[4-[2-〈diethylamino〉ethoxy]phenyl]-〈4-methylphenyl〉benzeneethanol, MER-29).17,71,192 Triparanol lowers blood cholesterol by inhibiting 75% or more of the endogenous synthesis. It blocks the reduction of the 24, 25 double bond in the steroid side chain, leading to the accumulation of 25-dehydrocholesterol, as it is commonly known, desmosterol.627 Desmosterol replaces cholesterol in lipoproteins, and therefore, triparanol therapy leads to the accumulation of the precursor compound in the blood in place of cholesterol. The lipoprotein pattern returns to normal in Type II patients but not in Type IV. Probucol has no consistent action on lipogenesis in experiments, but apparently decreases endogenous cholesterol synthesis and intestinal reabsorption.
Hair loss from drugs and radiation
Published in Jerry Shapiro, Nina Otberg, Hair Loss and Restoration, 2015
Agents that block cholesterol synthesis through a variety of mechanisms can disrupt keratinization. Cholesterol is a component of cellular lipids, and its synthesis and metabolism are essential for the production of normal epidermal structures. Triparanol, which has been withdrawn from the market because of cataract induction, can cause significant alopecia, loss of hair color, and ichthyosis. Clofibrate may occasionally produce hair loss.
Alternate Pathways of Steroid Biosynthesis and the Origin, Metabolism, and Biological Effects of Ring B Unsaturated Estrogens
Published in Ronald Hobkirk, Steroid Biochemistry, 1979
B. R. Bhavnani, C. A. Woolever
Goodman et al.86 demonstrated that desmosterol, an immediate precursor of cholesterol (Figure 7), was directly transformed to steroid hormones and bile acid in humans treated with triparanol (1-(p-β-diethylaminoethoxyphenyl)-1-(p-tolyl)-2-(p-chlorophenyl) ethanol), a drug which inhibits the reduction of the Δ24 bond of desmosterol.
Hedychium coronarium Rhizomes: Promising Antidiabetic and Natural Inhibitor of α-Amylase and α-Glucosidase
Published in Journal of Dietary Supplements, 2020
Suchitra K. Panigrahy, Awanish Kumar, Renu Bhatt
The fraction F3 showing highest inhibition revealed the presence of eight different chemotypes, which were characterized and distinguished by comparison of their mass fragmentation patterns. Of these eight compounds, six known and two unknown compounds were identified. Compound 1 with retention time 1.68 was tentatively identified as triparanol. It is a phenyl alcohol with reported cholesterol-lowering effect (Steinberg et al. 1961). The other compounds 3-hydroxysuberic acid, diltiazem, ginkgolide C, and swietenine have already been reported for their antidiabetic activity (Table 3). The sixth compound, digoxigenin monodigitoxoside, which is a glycoside, has also been reported but its activity as an antidiabetic agent is unclear.