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Solanine (Nightshade Glycoalkaloids)
Published in Dongyou Liu, Handbook of Foodborne Diseases, 2018
Filomena Lelario, Laura Scrano, Sabino Aurelio Bufo, Maryam Bader, Donia Karaman, Ameen Thawabteh, Rafik Karaman
Two other spirosolane-type GAs that play an important role in the metabolism of Solanum species are α-tomatine and dehydrotomatine. These compounds are most represented in tomato plants and only differ by the presence or absence of a double bond in the aglycone structure, tomatidine (α-tomatine), or tomatidenol (dehydrotomatine), to which a tetrasaccharide moiety lycotetraose is attached.
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
Fruits widely eaten in salads, sauces, soups, and stews, both raw and cooked, green (sometimes regarded as dangerous), and ripe. Seeds yield circa 25% oil, used for margarines, salad oils, and soaps. The residues are used as feed and mulch.61 A process for converting tomatidine into allopregnenolone has been worked out; the latter can be transformed into progesterone or testosterone. Tomatine is used as a precipitating agent for cholesterol.1 Tomato juice inhibits the germination of some weedy crucifers. The leaf infusion has been effectively sprayed in cabbage caterpillars.16 Tomatine is fungicidal.42
Steroidal Alkaloids
Published in Amritpal Singh Saroya, Contemporary Phytomedicines, 2017
Tomatine is a glycoalkaloid found in the stems and leaves of Lycopersicon esculentum (Kozukue et al. 2004). Its aglycone is tomatidine. It is a strong fungitoxic. Anticarcinogenic, cardioprotective, and other health benefits of tomato compounds lycopene, a-tomatine, and tomatidine has been discussed (Friedman 2013). Dehydrotomatine is another glycoalkaloid found in tomato (Kozukue et al. 2004).
Understanding host responses to equine encephalitis virus infection: implications for therapeutic development
Published in Expert Review of Anti-infective Therapy, 2022
Kylene Kehn-Hall, Steven B. Bradfute
A recent VEEV nsP3 interactome study identified 160 putative host interacting proteins, including eukaryotic initiation factor 2 subunit 2 (eIF2S2) and transcription factor AP-2 alpha (TFAP2A) which were validated for their importance in VEEV production through siRNA studies [83]. eIF2S2 was found to facilitate VEEV genomic RNA translation, but not translation of the subgenomic RNA [83]. Citalopram HBr and Z-VEID-FMK, inhibitors of TFAP2A, and Tomatidine, a small molecule inhibitor of eIF2S2, decreased VEEV production by >10 fold. Citalopram HBr, Z-VEID-FMK, and Tomatidine also suppressed EEEV replication.