China
Africa
Explore chapters and articles related to this topic
Tioconazole
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Tioconazole is a broad spectrum imidazole antifungal used to treat fungal and yeast infections. Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the fungal cell membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Tioconazole is indicated for the local treatment of vulvovaginal candidiasis, dermatophyte skin and nail infections and tinea (pityriasis) versicolor (1).
Topical Azoles
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Joanne L. Sharp, Michael A. Pfaller
These topical agents are generally considered safe in pregnancy because of their relatively low bioavailability. In some cases (e.g. tioconazole nail solution) use in pregnancy is contraindicated because of the duration of therapy. Some agents (e.g. clotrimazole, econazole) are also secreted in breast milk, thus theoretically exposing a nursing child. A decision must be made whether to discontinue breastfeeding or application of the agent in this setting.
Screening of in vitro antimicrobial activity of plants used in traditional Indonesian medicine
Published in Pharmaceutical Biology, 2018
Andreas Romulo, Ervizal A. M. Zuhud, Johana Rondevaldova, Ladislav Kokoska
MICs were determined by the broth microdilution method using 96-well microplates modified according to previous recommendations for the effective assessment of the antimicrobial potential of natural products (Clinical and Laboratory Standards Institute 2009; Cos et al. 2006). Assay microplate preparation and serial dilution were performed using the automated pipetting platform Freedom EVO 100 (Tecan, Mannedorf, Switzerland). Serial dilutions (100 μL) of each extract were distributed into the plate and diluted in the MHB making concentrations ranging from 4 to 512 μg/mL. Thereafter, the plates were inoculated with the respective microorganism suspension to make a final density 5 × 105 CFU/mL for bacteria and 1.5 × 103 CFU/mL for yeast, respectively. Plates were then incubated at 37 °C for 24 h (48 h for C. albicans). Microorganism growth was measured in terms of turbidity recorded at 405 nm (Cos et al. 2006) by a Cytation 3 microplate reader (BioTek, Winooski, VT). The MIC was expressed as the lowest concentration that showed ≥80% inhibition of microbial growth compared to an extract-free growth control. The antibiotics tetracycline and tioconazole (Sigma-Aldrich, Prague, Czech Republic) were dissolved in ethanol (Sigma-Aldrich, Prague, Czech Republic) and used as positive controls. The solvents used (DMSO and ethanol) did not inhibit bacterial growth at the concentrations tested (≤1%). Results reported in this study were expressed as the median/mode of MICs obtained from three independent experiments that were assayed in triplicate.
Miconazole for the treatment of vulvovaginal candidiasis. In vitro, in vivo and clinical results. Review of the literature
Published in Journal of Obstetrics and Gynaecology, 2023
Pedro Antonio Regidor, Manopchai Thamkhantho, Chenchit Chayachinda, Santiago Palacios
The US Centers for Disease Control and Prevention (CDC) and other clinicians generally recommend that uncomplicated vulvovaginal candidiasis (defined as vulvovaginal candidiasis that is mild to moderate, sporadic or infrequent, most likely caused by C. albicans, or occurring in immunocompetent women) should be treated with an intravaginal azole antifungal (e.g. butoconazole, clotrimazole, miconazole, terconazole and tioconazole) given in an appropriate single-dose or short-course regimens or oral fluconazole given in a single-dose regimen (Sobel 1994, 1997, Tobin 1995, Hay 1996, Sobel et al.1998, Lansdorp et al.1999, Workowski and Bachmann 2022).
Fractional carbon dioxide laser assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis
Published in Journal of Dermatological Treatment, 2019
Essam Bakr Abd El-Aal, Hamed Mohamed Abdo, Shady Mahmoud Ibrahim, Mostafa Taha Eldestawy
Tazarotene is a synthetic third-generation retinoid derived from vitamin A, which has proved to be useful in moderating keratinocyte proliferation and in reducing inflammation. Moreover, tazarotene can exert a defensive action on the microvascular bed against fungal infection (9). The aim of this study was to evaluate the clinical and mycological efficacy of fractional CO2 laser-assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.