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Therapeutic Potential of Nigella sativa (Black Seed)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
This chapter will discuss the historical and religious importance of black seed, its nutritional values and phytochemical constituents, especially thymoquinone, and the pharmacological activities of Nigella sativa.
The Role of Natural Products in COVID-19
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Iqra Akhtar, Sumera Javad, Tehreema Iftikhar, Amina Tariq, Hammad Majeed, Asma Ahmad, Muhammad Arfan, M. Zia-Ul-Haq
Thymoquinone (Figure 11.12), which is an active ingredient of the N. sativa extract, has been reported to enhance the activity and survival of CD8+ve cells, thus boosting the immune system against viral antigens [150]. It has also the capability of reducing the formation of microthrombus in the body, thus reducing the chances of COVID-19 induced multiple organ failure [145].
Herbal Anti-Arthritic Drug Discovery Tool Based on Inflammatory Biomarkers
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Sarwar Beg
Thymoquinone (TQ) is a major bioflavonoid isolated from Nigella sativa seeds. In Far and middle-Eastern Countries, it is extensively used as an alternative medicine to treat several diseases. Various literature surveys indicate the benefits of TQ in inflammation such as osteoarthritis. RA and inflammatory bowel disease (Umar et al., 2015). In a study on adjuvant-induced arthritis (AIA) conducted by Tekeoglu and Colleagues explored when TQ is administered by injection into the intraperitoneal (I.P) cavity it exhibits the same therapeutic value as MTX (Tekeoglu et al., 2007). Another study confirmed that TQ on oral administration at 5 mg/Kg/day leads to inhibition of the serum TNF-a and IL-113 level in RA (Ahmed et al., 2013).
Modulation of gene expression by thymoquinone conjugated zinc oxide nanoparticles arrested cell cycle, DNA damage and increased apoptosis in triple negative breast cancer cell line MDA-MB-231
Published in Drug Development and Industrial Pharmacy, 2021
Banupriya SJS, Kavithaa K, Poornima A, Haribalan P, Sri Renukadevi B, Sumathi. S
Nature is the best chemist and medicinal plants are the basic source of compounds that are used for all ailments to treat mankind. Collections of diverse bioactive secondary metabolites were synthesized by plants which can be used for pharmacological and therapeutic applications and most of the anticancer drugs were synthesized from medicinal plants. Medicinal plants are gaining global importance due to its minimal side effects [6]. Thymoquinone (2-methyl 5-isopropyl 1,4-benzoquinone) a bioactive substance (commercially available) was extracted from the black seeds of the plant Nigella sativa and it has effective anti-cancerous property. The phytoconstituents present in these seeds are dithymoquinone, thymohydroquinone, thymoquinone and thymol. Among these thymoquinone has anti-tumor activity against various types of cancers. Thymoquinone has poor bioavailability and so to overcome that physiological barricade targeted drug delivery system was approached through nanocarriers to enhance the site specific treatment [7].
Nutrition in the management of type 2 diabetes mellitus: review
Published in Archives of Physiology and Biochemistry, 2021
Clinical and statistically significant reduction in FBS and HbA1c levels following Nigella sativa ingestion with either form provided strong evidence for the incorporation of N. sativa as part of treatment in diabetes. Mechanisms underlying the therapeutic effects of N. sativa on glycaemia suggested amelioration of pancreatic β-cells resulting in insulin secretion, diminishing hepatic gluconeogenesis (Fararh et al.2004) and inducing insulin sensitivity in peripheral tissue (Benhaddou-Andaloussi et al.2008). These effects are attributable to active ingredients of N. sativa (e.g. thymoquinone(TQ), dithymoquinone, linoleic acid, and oleic acid) (Fararh et al.2010), although limited research has been done in this respect. It has been reported that the thymoquinone administration to STZ-nicotinamide-induced diabetic rats revealed hypoglycaemic benefits (Pari and Sankaranarayanan 2009).
Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data
Published in Drug Metabolism Reviews, 2021
Jaydeep Yadav, Mehdi El Hassani, Jasleen Sodhi, Volker M. Lauschke, Jessica H. Hartman, Laura E. Russell
Alkharfy et al. recently studied the effects of compromised liver function on the PK of thymoquinone in a Wistar rat model (Alkharfy et al. 2020). Liver impairment was induced with a single intraperitoneal injection of 800 mg/kg d-galactosamine. Galactosamine is a potent hepatotoxic substance that induces both hepatocyte necrosis and apoptosis by inhibiting hepatic RNA synthesis via the production of uridine diphosphate hexosamines, limiting DNA transcription (Apte 2014; Saracyn et al. 2015). Treatments with D-galactosamine and gentamicin were able to produce significant hepatic and kidney injury respectively which was confirmed by a significant increase in systemic biomarkers (AST and ALT levels for liver and Scr and BUN for kidney) as compared to control rats (Alkharfy et al. 2020).