China
Africa
Explore chapters and articles related to this topic
Therapeutic Potential of Nigella sativa (Black Seed)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Nigella sativa is typically recognised by the names of black cumin, kalonji, habbatus sauda and black seed; its countless nutritional and medicinal values commonly distinguish it from other herbs. Black seed has numerous nutrients, including vitamins, minerals and other phytoconstituents, especially thymol, carvacrol and thymoquinone, which has remarkable medicinal properties. The seed extract of Nigella sativa is stated to have a range of therapeutic properties, including anti-inflammatory, anticancer, antidiabetic, anti-infectious and immunity-boosting effects. The plant Nigella sativa belongs to the Ranunculaceae family and is considered one of the substantial medicinal plants in history; it has been advised for thousands of years, and it also has religious importance because it is mentioned in the holy books of different religions. The latest various research and scientific studies have validated all the traditional claims about black cumin (Gilani et al., 2004; Tavakkoli et al., 2017).
Thymoquinone-Loaded Nanocarriers for Healthcare Applications
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Ruqaiyah Khan, Himani Nautiyal, Shakir Saleem
Bioactive compounds are one of the best alternative sources which can be employed in the prevention and treatment of various kinds of diseases including cancer (Shanmugam et al., 2018). Nigella sativa, also known as Black cumin, is an ancient herbal drug which is traditionally used to cure several conditions like asthma, bronchitis, inflammation, eczema, fever, influenza, hypertension (HTN), cough, headache, dizziness (Schneider et al., 2014; Ballout et al., 2018). Additionally, recent researches have revealed that black cumin can also be used to alleviate ailments like diabetes, renal, and liver malfunction, nervous system problems, rheumatic diseases, cancer, inflammatory diseases, gastrointestinal problems, and also for overall general wellness (Banerjee et al., 2010; Asaduzzaman et al., 2017).
Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
The essential black cumin oil is used as condiment, carminative, analgesic and food preservative and has been recommended as a remedy for various medical conditions (12). The possible health effects of Nigella sativa (products) have been reviewed (1,3,4), pharmacological properties summarized (5) and clinical trials of Nigella sativa products and its important constituent thymoquinone assessed (14).
Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production
Published in Archives of Physiology and Biochemistry, 2023
Soheila Jangjo-Borazjani, Maryam Dastgheib, Efat Kiyamarsi, Roghayeh Jamshidi, Saleh Rahmati-Ahmadabad, Masoumeh Helalizadeh, Roya Iraji, Stephen M Cornish, Shiva Mohammadi-Darestani, Zohreh Khojasteh, Mohammad Ali Azarbayjani
Results of this study showed that resistance training with Nigella sativa lead to a significant decrease in ESR. ESR is a test that indirectly measures the degree of inflammation present in the body. As noted above, resistance training reduces inflammation through various mechanisms. Also Nigella sativa can reduce inflammation. Some studies have shown that Nigella sativa inhibit inflammatory cytokines such as IL-1 and IL-6 (Shuid et al.2012). In another study, administration of aqueous extract of N. sativa inhibits production of 5-lipooxygenase (El-Dakhakhny et al.2002). Also the anti-inflammatory effects of N. sativa extract on LPS-induced inflammation in the mixed-glial cells and macrophages indicates a reduction in nitric oxide production by these cells (Salem 2005), which is probably due to the inhibition of inducible nitric oxide synthase (iNOS) by TQ (Mahmood et al.2003).
Neuroprotective role of medicinal plant extracts evaluated in a scopolamine-induced rat model of Alzheimer's disease
Published in Biomarkers, 2022
Asmaa K. Abdelghany, El-Shymaa El-Nahass, Marwa A. Ibrahim, Akram. M. El-Kashlan, H.H. Emeash, Fatma Khalil
The 90 rats were randomly allocated into six groups of 15 animals: (i) control, receiving intraperitoneal (IP) saline injections; (ii) SCO -treated group, receiving IP injection of scopolamine hydrobromide trihydrate in saline solution, at a dose of 2.2 mg/kg (Bihaqi et al.2012; Lee et al., 2014; Hafez et al., 2017); (iii) NS-treated group, receiving SCO-treatment plus per os (PO) administration of ethanolic extract of nigella sativa at a dose of 400 mg/kg (Hosseini et al., 2015); (iv) RO-treated group, receiving SCO-treatment plus ethanolic extract of Rosmarinus officinalis (200 mg/kg, PO) (Ozarowski et al., 2013); (v) SO-treated group, receiving SCO-treatment plus ethanolic extract of salvia officinalis (600 mg/kg, PO) (Hasanein et al., 2016); and (vi) GS-treated group, receiving SCO-treatment plus ethanolic extract of ginseng (200 mg/kg, PO) (Lee et al., 2010). All groups received treatments daily for 2 months. In groups (iii-vi), extracts were orally gavaged 90 minutes after SCO injection.
Thymoquinone improved redox homeostasis in the heart and aorta of hypothyroid rats
Published in Clinical and Experimental Hypertension, 2022
Yousef Baghcheghi, Farimah Beheshti, Fatemeh Seyedi, Mahmoud Hosseini, Mahdiyeh Hedayati-Moghadam
In recent years, the therapeutic potential of various plants and plant-derived compounds in cardiovascular diseases has gained a lot of attention (17,19,27,43–45) Scholars have assessed the potential health benefits of plants for their cardio-protective properties and the ability of these plants to improve heart disease plays an important role in folk medicine (44). As one of the promising medicinal plants, Nigella sativa has been used traditionally in treating a variety of ailments (46). It is a member of the Ranunculaceae family (47). This plant is commonly known as black seed and has been widely used by countries in the Middle East and Far East for centuries as a means of protecting health and overcoming diseases (48). TMQ is one of the main phytochemicals found in the Nigella sativa. It is nontoxic and can be used to treat a wide variety of human diseases, including cardiovascular disorders and cancer. Nigella sativa and TMQ are reported to reduce the negative effects of asthma, inflammation, arthritis, and gastrointestinal, liver, and cardiovascular disorders (47,49). TMQ also has many pharmacological actions, including antioxidant, antihyperglycemic, anti-inflammatory, antihistaminic, immunomodulatory, and antitumor effects (50–52).