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A Comparative Study of Organic Pollutants in Seawater, Sediments, and Oyster Tissues at Hab River Delta, Balochistan Coast, Pakistan
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Sadar Aslam, Malik Wajid Hussain Chan, Grzegorz Boczkaj, Ghazala Siddiqui
The preliminary chemical profiling by GC-MS of seawater and sediments samples from the Hab River Delta revealed the presence of the following seven major groups based on their chemical structure to commonly known classes of compounds: Alkanes (decane, undecane, tetradecane, pentadecane, heptadecane, octadecane, nonadecane, heneicosane, tricosane)Alkenes (decylbenzene, 1-octadecene and 2E)-3,7,11,15-Tetramethyl-2- hexadecene)Ketones (benzophenone)Other organic pollutants (dibenzyl ether)Aromatic hydrocarbons (1,2,3-trimethyIbenzene, indane, 1,4-diethylbenzene, octylbenzene, m-terphenyl; p-terphenyl;3-methylbiphenyl)Cycloalkanes (trans-decalin, octylcyclohexane)Polycyclic aromatic hydrocarbons (PAHs; 2-naphthalenol; 1-phenylnaphthalene; 1-methylanthracene; 3,6-dimethylphenanthrene; anthracene; fluoranthene; pyrene; phenanthrene;9,10-dimethylanthracene; Table 10.1).
Allergic Contact Dermatitis from Rubber and Plastic Gloves
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
Contact allergy to polyvinylchloride (PVC) gloves have been seldomly reported. However, a study conducted a test on patients who had positive patch test reactions to PVC gloves. The study obtained a collection of PVC raw materials from industrial producers and suppliers—isocyanates and isocyanate prepolymers, plastics, and glue series.71 Nine PVC glove samples for triphenyl phosphate and its derivatives were analyzed. Two patients reacted to a technical PVC antioxidant and triphenyl phosphite (TPP), one of its components. Contact allergy to TPP was prominent in one patient and the main cause of hand dermatitis. The other patient had other contact allergies that explained the symptoms. Three patients reacted to the PVC gloves; however, a specific allergen was not identified. It was determined that six of the PVC glove samples contained TPP at 0.004%–0.099%. During storage, TPP transforms into triphenyl phosphate. Overall, TPP represents a new allergen detected in high concentrations in PVC gloves.71
Notes on Genetic and Radiation Control of Senescence
Published in Nate F. Cardarelli, The Thymus in Health and Senescence, 2019
Later, Arakawa showed that dibutyl-, tributyl-, triphenyl-, and dioctyltin inhibit RNA synthesis, RNA polymerase activity, phospholipid synthesis, and arachidonic acid release by lymphocytes in vitro, in a dose-dependent manner.201 The DNA inhibitory process suppresses DNA synthesis.202In vivo evaluations confirm that organotins act at the nuclear level on DNA synthesis.203 The suppressor action of the dibutyltins may be targeted on DNA-RNA transcription at a uridine site on the DNA. In a recent report, Penninks et al. note that dibutyltin chloride inhibits DNA and thus protein synthesis by decreasing the thymidine, leucine, and glycine uptake of cells, but also by inducing an increase in uridine uptake and glycolysis.204
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery
Published in Drug Delivery, 2023
Simeng Xiao, Siying Huang, Xiaojing Yang, Yujie Lei, Mingxiang Chang, Junjie Hu, Yan Meng, Guohua Zheng, Xinyan Chen
TPP (5-carboxyl amyl triphenyl phosphorus bromide, 1 mmol) was dissolved in dichloromethane with DCC (1.2 mmol) and DMAP (1.2 mmol), and reacted for 3 h under nitrogen protection to activate carboxyl. Cholesterol (1 mmol) dissolved in dichloromethane was added drop by drop to the mixture and continuously reacted under stirring for 21 h. The end product CT was extracted by dilute hydrochloric acid, and then isolated and purified by preparative liquid chromatography. Its structure was characterized by 1H NMR (Advance 400, Bruker), 13 C NMR (Advance 400, Bruker), FTIR (Vertex 70, Bruker), and ESI-HRMS (Q Exactive, Thermo Scientific). CDCl3 was used as NMR solvent. FTIR samples were prepared by dissolving CT in chloroform, dropping it onto the glass slide, and drying it under deuterium lamp. Finally, the purity of CT was analyzed by HPLC (1260 Infitiny, Agilent) performed on an InertSustain C18 (250 mm × 4.6 mm, 5 μm) column. HPLC conditions: 100% methanol; flow rate 1 mL/min; detection wavelength 287 nm.
WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathway
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Mohammed A. F. Elewa, Wagdy M. Eldehna, Ahmed M. E. Hamdan, Samraa H. Abd El-kawi, Asmaa M. El-Kalaawy, Taghreed A. Majrashi, Reham F. Barghash, Hatem A. Abdel-Aziz, Khalid S. Hashem, Mohammed M. H. Al-Gayyar
One of the candidate therapeutic agents against HCC is pyrazolo[3,4-b] pyridine compounds, which are small molecules proved as antitumor,4,5 antibacterial,6 anti-inflammatory7 and antioxidant.8 Of these novel synthesised pyrazolo[3,4-b]pyridine compounds is 4–(4-hydroxyphenyl)-1,3,6-triphenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile, WRH-2412 (Figure 1). Recently, WRH-2412 has been proven to have promising in vitro anticancer action with broad spectrum anti-proliferative activities as disclosed through the US-NCI assays, with outstanding growth inhibition full panel GI50 (MG-MID) value equals 2.16 μM.9 Interestingly, the antitumor activity of WRH-2412 against HCC hasn’t been investigated in vitro or in vivo.
Glucosamine modulates membrane and cellular ionic homeostasis: studies on accelerated senescent and naturally aged rats
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Komal Saraswat, Raushan Kumar, Syed Ibrahim Rizvi
Erythrocyte membrane lipid hydroperoxides were determined according to the method of Firuzi et al [25]. In two separate test tubes, 180 µl of the membrane was taken. In the first tube, 20 µl methanolic triphenyl phosphine (TPP) was added, while in the other methanol was added and both the tubes were kept in the dark for 30 minutes. Then, 1.8 ml of FOX solution was added to both the tubes and kept for incubation for 1 hr at room temperature in the dark. The tubes were vortex every 10 minutes. After the incubation period, tubes were centrifuged at 16,000 × g for 7 minutes and the supernatant was used to measure the absorbance was measured at 560 nm. A calibration curve of H2O2 (range 1–10 µM) was used in calculating the results. The value of LH was expressed as nmol/mg membrane protein.