China
Africa
Explore chapters and articles related to this topic
Anti-Inflammatory, Antimicrobial and Other Beneficial Effects of Allium sativum (Garlic)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Moreover, ajoene was also identified to counteract the activity of COX2 and the secretion of prostaglandin E2. One of the organosulfur constituents of garlic, diallyl trisulfide, has prospective anti-inflammatory activity, and it works by decreasing the cytokines and arbitrates in in vivo and in vitro experiments (Walag et al., 2020). Furthermore, this constituent also demonstrated the capacity of inhibiting LPS (lipopolysaccharide)-prompted foot oedema in rat models. Sulforaphane was also established to be beneficial as a healing agent for managing inflammation-associated disorders (Chen et al., 2009).
Chemopreventive Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
Sulforaphane (Figure 12.33) is an organosulfur isothiocyanate compound found in cruciferous vegetables. Broccoli sprouts contain the highest concentration of sulforaphane, but it is also found in Chinese broccoli and broccoli raab, Brussels sprouts, cauliflower, cabbage, kale, bok choy, mustard, watercress, arugula, radish, turnip, collards, kohlrabi, and some fruits. Sulforaphane is formed from a glucosinolate precursor sulforaphane glucosinolate (SGS), also known as glucoraphanin. It is produced as a response to physical damage (such as chewing), which causes the release of the enzyme myrosinase and the conversion of glucoraphanin to sulforaphane. Structure of sulforaphane glucosinolate (SGS, or glucoraphanin) and its conversion to L-sulforaphane by the enzyme myrosinase in response to physical damage to the plant (e.g., chewing).
PerformLyte—A Prodosomed PL425 PEC Phytoceutical-Enriched Electrolyte Supplement—Supports Nutrient Repletion, Healthy Blood pH, Neuromuscular Synergy, Cellular and Metabolic Homeostasis
Published in Abhai Kumar, Debasis Bagchi, Antioxidants and Functional Foods for Neurodegenerative Disorders, 2021
Bernard W. Downs, Manashi Bagchi, Bruce S. Morrison, Jeffrey Galvin, Steve Kushner, Debasis Bagchi
Sulforaphane Standardized Brassica oleracea var. (family Brassicaceae) Broccoli sprout seed concentrate is a rich source of SFN, vitamins A, B9 (folate), C, and K, and micronutrients (phosphorous, potassium, and selenium).86,87Standardized Brassica oleracea var. (family Brassicaceae) Broccoli floret and stem concentrate contains SFN and is a rich source of vitamins A, B9, C, and K, and folate, as well as micronutrients (phosphorous, potassium, and selenium).86,87Standardized Brassica oleracea var. (family Brassicaceae) Brussels sprout edible head concentrate contains SFN, which protects against neurodegenerative diseases and aberrant cell mutations.86,87
Sulforaphane Suppresses MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect of Butyl Benzyl Phthalate
Published in Nutrition and Cancer, 2023
Wanshuang Cao, Xiaomin Lu, Caiyun Zhong, Jieshu Wu
Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane; SFN) is a common phytochemical that is widespread in cruciferous vegetables, such as broccoli, cauliflower, Brussel sprouts, cabbage, kale, and kohlrabi (1). Broccoli is the best-known source of SFN and contains up to 60 mg of glucoraphanin, an SFN precursor, per serving, depending on the season, type, and freshness (2). As early as 2000, a case-control study suggested that male subjects who consumed three or more servings of cruciferous vegetables per week presented a 41% reduced risk of prostate cancer than those who consumed less than one serving per week (3). In 2019, a randomized double-blinded intervention revealed that consuming glucoraphanin-rich broccoli soup for one year could retard the progression of prostate cancer by influencing cancer-related gene expression (4). To date, SFN has been deemed a candidate for anticancer therapy in various cancers, including prostate (5) and breast (6) cancer, and the combination of SFN with chemotherapeutic drugs has exhibited improved efficacy and reduced side effects (5).
Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis
Published in Toxicology Mechanisms and Methods, 2022
Sulforaphane is 1-isothiocyanato-4-(methylsulfinyl) butane that is obtained from vegetables of the Cruciferae family, such as broccoli, broccoli sprouts, cauliflower, and cabbage. Sulforaphane is reported to inhibit UV-induced inflammation (Dinkova-Kostova et al. 2006; Shibata et al. 2010). Two previous studies illustrated the therapeutic effects of sulforaphane in experimentally induced AD in mice through inhibition of Nrf2/HO-1 axis (Wu et al. 2019) or through inhibition of TARC/CCL17 and MDC/CCL22 expression (Jeong et al. 2010). In addition, sulforaphane has minimal side effects in patients or mice as well as it is highly soluble and bioavailable (Li et al. 2013). Therefore, we conducted this study to examine the therapeutic effect of sulforaphane on experimentally induced AD in mice focusing on DNA oxidative damage and the balance between pro-inflammatory and anti-inflammatory cytokines. In addition, we aimed to examine the effect of sulforaphane on AD-induced activation of the apoptotic pathway.
The Potential for Reducing Lynch Syndrome Cancer Risk with Nutritional Nrf2 Activators
Published in Nutrition and Cancer, 2021
Sulforaphane is a phytochemical of the organosulfur compound classification known as an isothiocyanate and found predominantly in the cruciferous vegetable family, particularly Brassica oleracea (76, 82, 87). Common culinary vegetables in the Brassica oleracea family include broccoli, cabbage, cauliflower, kale, Brussels sprouts, collard greens, savoy, and kohlrabi. However, sulforaphane itself is not present in these vegetables, its precursor glucoraphanin (GRN) and a vacuole enzyme Myrosinase (MYR) are present (76, 82). MYR is found within the cells of Brassica vegetables, separately compartmentalized from GRN, and when the cell wall is ruptured (ex. chewing, cutting, and/or crushing), MYG and GRN interact to produce sulforaphane (76, 82). As with the other mentioned phytochemicals, sulforaphane and cruciferous vegetable intake have been linked to multiple health benefits including reducing the risk of many chronic diseases such as cancer, diabetes, obesity, cardiovascular disease, and neurodegeneration (82, 87, 132–137). Sulforaphane is not a direct free radical scavenger and the health benefits of this compound are mainly hypothesized to be due to its potent ability to activate the Nrf2 pathway (76, 82, 87). Sulforaphane has been shown to activate the Nrf2 pathway through two mechanisms. Sulforaphane is able to alter Keap1 in a cysteine dependant manner and has also been shown to activate upstream kinases leading to Nrf2 phosphorylation; both scenarios triggering Nrf2 translocation to the nucleus (76, 82, 87).