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Postmenopause
Published in Carolyn Torkelson, Catherine Marienau, Beyond Menopause, 2023
Carolyn Torkelson, Catherine Marienau
As you consider foods that are beneficial, we advise you to follow the age-old adage to “eat your veggies.” Vegetables have antioxidant value and are low in calories, which helps manage weight and support healthy physical and mental well-being. Cruciferous vegetables are essential because they are rich in vitamins (folate and vitamin K), minerals (selenium and calcium), phytochemicals (plant sterols and indole-3-carbinol), and essential sulfur-containing compounds (called glucosinolates). The health benefits of cruciferous vegetables have been studied extensively. Many of the compounds in these vegetables synergistically contribute to health promotion such as anti-cancer, anti-inflammatory, and antioxidant capacities. Some studies have suggested that indole-3-carbinol (active metabolites in cruciferous vegetables) strongly influences estradiol metabolism and may be a new approach to prevent estrogen-dependent diseases. If you can make just one change to your diet, start by adding one serving of cruciferous vegetables to your daily meal plan.
Hyperthyroidism
Published in Charles Theisler, Adjuvant Medical Care, 2023
Diet: Some cruciferous vegetables contain compounds that decrease thyroid hormone production. Examples are brussels sprouts, cabbage, cauliflower, collard greens, mustard greens, turnip roots and greens, kale, radishes, and rutabagas.9
A lady with abdominal cramps
Published in Tim French, Terry Wardle, The Problem-Based Learning Workbook, 2022
Vegetables such as beans, broccoli, brussel sprouts and cabbage rely on commensal gut flora in the colon for their digestion. The production of gas during digestion can lead to uncomfortable distension in FBD sufferers with visceral hypersensitivity. Consequently, a trial of a modified diet with reduced leguminous or cruciferous vegetable content may help.
The Potential for Reducing Lynch Syndrome Cancer Risk with Nutritional Nrf2 Activators
Published in Nutrition and Cancer, 2021
Sulforaphane is a phytochemical of the organosulfur compound classification known as an isothiocyanate and found predominantly in the cruciferous vegetable family, particularly Brassica oleracea (76, 82, 87). Common culinary vegetables in the Brassica oleracea family include broccoli, cabbage, cauliflower, kale, Brussels sprouts, collard greens, savoy, and kohlrabi. However, sulforaphane itself is not present in these vegetables, its precursor glucoraphanin (GRN) and a vacuole enzyme Myrosinase (MYR) are present (76, 82). MYR is found within the cells of Brassica vegetables, separately compartmentalized from GRN, and when the cell wall is ruptured (ex. chewing, cutting, and/or crushing), MYG and GRN interact to produce sulforaphane (76, 82). As with the other mentioned phytochemicals, sulforaphane and cruciferous vegetable intake have been linked to multiple health benefits including reducing the risk of many chronic diseases such as cancer, diabetes, obesity, cardiovascular disease, and neurodegeneration (82, 87, 132–137). Sulforaphane is not a direct free radical scavenger and the health benefits of this compound are mainly hypothesized to be due to its potent ability to activate the Nrf2 pathway (76, 82, 87). Sulforaphane has been shown to activate the Nrf2 pathway through two mechanisms. Sulforaphane is able to alter Keap1 in a cysteine dependant manner and has also been shown to activate upstream kinases leading to Nrf2 phosphorylation; both scenarios triggering Nrf2 translocation to the nucleus (76, 82, 87).
Ethylcellulose microparticles enhance 3,3′-diindolylmethane anti-hypernociceptive action in an animal model of acute inflammatory pain
Published in Journal of Microencapsulation, 2020
Juliane Mattiazzi, Marcel Henrique Marcondes Sari, Paulo Cesar Oliveira Araujo, Andrei Vinícius Englert, Jéssica Mendes Nadal, Paulo Vítor Farago, Cristina Wayne Nogueira, Letícia Cruz
Although several epidemiological studies report the relationship between cruciferous vegetable consumption and disease prevention (Verhoeven et al. 1996, Higdon et al. 2007, Vasanthi et al. 2009), a large daily intake of these vegetables is required to achieve adequate doses of DIM (about 1.6 mg/Kg). This may occur because of DIM is a lipophilic compound with low bioavailability (1–3%) after oral administration (Roy et al. 2013, Wu et al. 2015). In addition, it may degrade after exposure to light or high temperatures (Vallejo et al. 2002, Luo et al. 2013). In order to meet these clinical needs, drug delivery systems have emerged as an interesting alternative as they are able to circumvent the limitations of conventional systems and optimise the treatment, presenting considerable positive impact on therapy (Li et al. 2008, Bhokare et al. 2015, dos Santos et al. 2016).
Bioactivation of herbal constituents: mechanisms and toxicological relevance
Published in Drug Metabolism Reviews, 2019
Like diallyl sulfides, isothiocyanates (ITCs) are another group of naturally occurring organosulfur compounds with inherent electrophilic reactivity. ITCs are the major bioactive ingredients of cruciferous vegetables which include commonly consumed products such as cauliflower, broccoli, radish, rocket salad and cabbage. Epidemiological studies have established the cancer chemopreventive activity of cruciferous vegetables with an inverse relationship between dietary intake of cruciferous vegetables and cancer incidences (Lam et al. 2009; Ambrosone et al. 2004). The chemopreventive activities of dietary ITCs are mainly attributed to their electrophilic –N=C=S moiety via (1) inhibition of CYP-mediated bioactivation of procarcinogens; (2) induction of phase II detoxification enzymes via Keap1/Nrf2/ARE pathway; (3) induction of cell cycle arrest and apoptosis (Mi et al. 2011; Zhang 2011; Nakamura et al. 2018).