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Anti-Hyperglycemic Property Of Medicinal Plants
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Karanpreet Singh Bhatia, Arpita Roy, Navneeta Bhardavaj
Lepidium sativum, with common name garden cress, belongs to Brassicaceae family and normally grown in France, England, Scandinavia, and Netherlands. Methanolic extract of L. sativum 20% (w/w) was shown to be able to induce hypoglycemia in STZ-I hyperglycemic rats and also it was observed that various parameters associated with diabetes like high lipid peroxidation, serum uric acid, creatinine, LDL, etc., were reversed and brought to normal levels (Qusti et al., 2016). In another study, methanolic extract of garden cress seeds, treatment was given to AI hyperglycemic rats for four weeks and it was found that restoration of several parameters like triglycerides levels, HbA1c, LDL, and many others. It also ameliorated lipid profile and increased antioxidants concentrations (Attia et al., 2017).
Components of Nutrition
Published in Christopher Cumo, Ancestral Diets and Nutrition, 2020
A second category, phytoestrogens, includes isoflavones, which appear to protect the body against heart disease, osteoporosis, and some cancers. Soybeans have the isoflavones genistein and daidzein, which may partly explain lower chronic-disease rates among East Asian than among Americans and Europeans. Another type of phytoestrogen, lignan, may offer comparable benefits and is numerous in flaxseeds (Linum usitatissimum). A third class of phytochemicals, phytosterols, resembles cholesterol and appears to lower it in blood. Soybean oil contains phytosterols, another factor that may help explain East Asians’ health. Fourth, glucosinolates may reduce damage from carcinogens and toxins by speeding their excretion, though clinical trials have yet to confirm this effect. Research focuses on glucosinolates sinigrin and progoitrin in hopes of evaluating their promise. These compounds are abundant in crucifers (also known as cole crops): broccoli, cauliflower, turnip (Brassica rapa ssp. rapa), kale, Brussels sprouts, garden cress (Lepidium sativum), bok choy (Brassica rapa ssp. chinensis), cabbage, and related plants. Fifth, the carotenoids include some 600 chemicals, notably vitamin A precursor beta carotene.87
Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Common names: jia du xing cai (Chinese); candsur (India); garden cressSubclass Dillenidae, Superorder Capparanae, Order Capparales, Family BrassicaeaeMedicinal use: diuretic (India)
Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa
Published in Xenobiotica, 2022
Mohd Aftab Alam, Yousef A. Bin Jardan, Mohammad Raish, Abdullah M. Al-Mohizea, Abdul Ahad, Fahad I. Al-Jenoobi
Lepidium sativum (L. sativum), also known as Garden cress (Brassicaceae family), is an edible herb. It is used as a culinary herb and also has huge potential for the treatment of various diseases (Prajapati et al. 2014; Raval and Pandya 2011). L. sativum is reported to has antimicrobial, antioxidant, and anti-inflammatory properties (Alqahtani et al. 2019); hypoglycaemic activity (Attia et al. 2019); antidiarrheal and spasmolytic activities (Rehman, Mehmood et al. 2012); treat hyperactive airways disorders, such as asthma, bronchitis and cough (Rehman, Khan et al. 2012); prokinetic and laxative activities (Najeeb-Ur-Rehman et al. 2011), and antihypertensive activity (Jouad et al. 2001; Maghrani et al. 2005). L. sativum is known to interfere in pharmacokinetics of some drugs. It has increased the area under curve (AUC0–t) of cytochrome P450 3A4 substrates: cyclosporine in rabbits (Al-Jenoobi et al. 2013) and carbamazepine (Alkharfy, Al-Jenoobi, Alam et al. 2013). It also increased the AUC0–t of phenytoin, a CYP2C9 and CYP2C19 substrate (Alkharfy, Al-Jenoobi, Al-Mohizea et al. 2013).
Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension
Published in Pharmaceutical Biology, 2021
Yousef A. Bin Jardan, Abdul Ahad, Mohammad Raish, Mohd Aftab Alam, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi
In this study, we used L-NAME-induced hypertension models to investigate the antihypertensive effects of three commonly used herbs, namely, garden cress (GC), fenugreek (FG), and black seed (BS); for this purpose, L-NAME was orally administered in rats, which induced a substantial increase in blood pressure. The outcomes of this study showed that metoprolol tartrate (MT) alone, herbs alone, and their combination showed a decrease in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in hypertensive rats. Heart rate (HR), which was depleted following treatment with L-NAME alone, improved following treatment with MT alone, herbs alone, and herbs + MT. A more potent blood pressure-lowering effect of MT was observed when administered in combination with herbs. Furthermore, the concurrent administration of drugs, particularly those predominantly cleared through CYP2D-catalyzed metabolism, with the three herbs under study should be considered with caution.