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Gastrointestinal diseases and pregnancy
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Murtaza Arif, Anjana Sathyamurthy, Jessica Winn, Jamal A. Ibdah
Sucralfate is FDA pregnancy category B and is a good alternative to antacids in pregnancy. It is a preferred drug for PUD during pregnancy because it is not absorbed systemically and has not been shown to be teratogenic in animal studies (12).
Medical Patients with Epilepsy
Published in Stanley R. Resor, Henn Kutt, The Medical Treatment of Epilepsy, 2020
Sucralfate is a relatively new addition to the drugs used to treat peptic ulcer disease. Little data exist regarding sucralfate’s effect on the absorption of most drugs, including most AEDs. However, sucralfate has been found to significantly reduce the absorption of PHT (28).
Peptic ulcer disease
Published in Michael JG Farthing, Anne B Ballinger, Drug Therapy for Gastrointestinal and Liver Diseases, 2019
Erik AJ Rauws, Guido NJ Tytgat
In an acidic environment, the aluminium salt forms a gel with a high affinity for damaged epithelium. It binds bile salts and pepsin, and also increases mucosal defence by the stimulation of bicarbonate and PGE2 secretion. Only a few long-term prevention studies with sucralfate for NSAID-induced lesions have been performed. In a 6-week placebo-controlled trial, sucralfate 1 g four times daily significantly reduced the severity of symptoms, but failed to influence the incidence of mucosal lesions.98 In a comparative study during 3 months, sucralfate 1 g four times daily was compared with misoprostol 200 μg four times daily.121 After 3 months, significantly less gastric ulcers developed in the misoprostol group (1.6%) compared with the sucralfate group (16%).
Potential applications of drug delivery technologies against radiation enteritis
Published in Expert Opinion on Drug Delivery, 2023
Dongdong Liu, Meng Wei, Wenrui Yan, Hua Xie, Yingbao Sun, Bochuan Yuan, Yiguang Jin
Sucralfate, an aluminum-based salt of sucrose octasulfate, is widely used in the treatment of radiation-induced rectal injury (especially hemorrhagic radiation proctitis) as a common intestinal mucosal protectant by covering the injured mucosal surface and promoting ulcer healing [81]. However, sucralfate enema suspensions are difficult to retain in the rectum of the patients with active proctitis due to intestinal peristalsis and fecal discharge, decreasing their effectiveness and compliance. Low-volume rectal administration of sucralfate paste enemas was applied to 23 patients with rectal bleeding for more than 6 months post-radiotherapy and hemorrhagic radiation proctitis was effectively mitigated [57]. A topical 7% sucralfate ointment was used twice daily from one day before and during radiotherapy for 6 weeks in a randomized double-blind placebo-controlled study, where 57 patients with pelvic malignancies underwent radiotherapy. Sucralfate ointments significantly alleviated the symptoms including diarrhea, rectal pain, rectal bleeding, and fecal urgency associated with acute radiation proctitis [58]. Therefore, sucralfate is not only used in the treatment of ARE and CRE but also can significantly prevent the occurrence of RE.
Gastroprotective effect of Hyssopus officinalis L. leaves via reduction of oxidative stress in indomethacin-induced gastric ulcer in experimental rats
Published in Drug and Chemical Toxicology, 2022
Mohd Tahir, Md Azizur Rahman, Mohammad Khushtar
Most of the conventional drugs used in the treatment of PUD like H2-receptor antagonists, proton pump inhibitors, antacids and anticholinergics have undesirable side effects and drug interactions (Dashputre and Naikwade 2011). Sucralfate and prostaglandin analogs used in PUD may also have risks of drug interactions, adverse effects and increased incidence of relapse during ulcer therapy (Dashputre and Naikwade 2011). Hence, search has been focused on natural products with antiulcer property but without these side effects, adverse effects, drug interactions and relapse of PUD. Also, there have been a quite high number of traditional remedies worldwide using plants to treat various human disorders of gastrointestinal system such as stomachache and PUD since thousands of years (Saranya et al. 2011). The latest trends have shown an increasing demand of natural products and medicinal herbs which have been proven to have antiulcer activity (Khushtar et al. 2009). Plant kingdom is the foremost source of novel natural products with potential to be used as drugs or pharmaceutical mediators (Khushtar et al. 2009). According to the World Health Organization, more than 80% of the world population in developing countries depends primarily on plant-based medicines for basic healthcare needs (Khushtar et al. 2016). Further, the role of medicinal plants in disease prevention or control has been attributed to antioxidant properties of their constituents, usually associated to a wide range of amphipathic molecules, broadly termed as polyphenolic compounds (Farzaei et al. 2015).
Pistacia atlantica Desf. roots extract: LC-ESI-MS Analysis, antioxidant activity and gastroprotective effect on experimentally-induced ultrastructural gastric ulcers in mice
Published in Ultrastructural Pathology, 2021
Marwa Ben Hmed, Hichem Alimi, Fatma Guesmi, Feriel Elatrech, Nacim Zouari, Yassine Chtourou, Ridha Ben Salem, Ghayth Rigane, Slim Cherif
The final product of lipid peroxidation (MDA) was generated under overproduction of free radicals and is regarded as a marker of cell injury and cytotoxicity.32,33 MDA level in the stomach is illustrated in figure 2. Our results are in harmony with the previously published study9 which showed a high increase (P< .01) in the stomach MDA level in EtOH group when compared with normal control group. Conversely, pretreatment with PR extract significantly reduced (P< .01), in dose-dependent manner, the increase of MDA content in stomach tissue of ulcerated mice. Meanwhile, the pretreatment with sucralfate showed a potent protective effect when compared with EtOH (P < .05). Among the possible mechanisms of antiulcer effect of Pistacia atlantica extract, there are antiradical and reducing power properties.