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Stannous Fluoride
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Stannous fluoride is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to sodium fluoride (NaF), which is the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective at stopping and reversing dental lesions. It manages and prevents dental caries and gingivitis by promoting enamel mineralization, reducing gingival inflammation and bleeding through its potential broad-spectrum antibiotic effect and modulation of the microbial composition of the dental biofilm. Also, a stable acid-resistant layer is deposited on the tooth surfaces which is composed of calcium fluoride produced when stannous fluoride converts the calcium mineral apatite into fluorapatite (1).
Inhalation Toxicity of Metal Particles and Vapors
Published in Jacob Loke, Pathophysiology and Treatment of Inhalation Injuries, 2020
Most tin is used as the metal in the manufacture of tin plate (a protective coating). Most of the rest is used in alloys, including solder, pewter, bronze, and brass. Stannous and stannic chlorides are used in dyeing textiles. Stannous fluoride is used in tooth pastes. Organic tin compounds have been used as antimicrobials, in antifouling paints, and as heat stabilizers in plastics (e.g., polyvinyl).
Periodontal Diseases
Published in Lars Granath, William D. McHugh, Systematized Prevention of Oral Disease: Theory and Practice, 2019
William D. McHugh, Lars Matsson, Sigmund S. Socransky
Stannous fluoride rinses have been shown to reduce plaque formation in short-term studies.147,154 However, less frequent use of weaker solutions over a longer 28 month period did not result in any plaque reduction.74
Knowledge on and treatment practices of erosive tooth wear among Finnish dentists
Published in Acta Odontologica Scandinavica, 2021
Hanna Kangasmaa, Tarja Tanner, Marja-Liisa Laitala, Aida Mulic, Simen E. Kopperud, Hannu Vähänikkilä, Vuokko Anttonen, Viivi Alaraudanjoki
The participants assessed patient’s dietary history in most cases (81%), whereas the respective figure is 45% in Norway and 50% in Iceland. Especially cariologists found it necessary to assess the patient’s dietary habits (96%). This is encouraging since lifestyle factors such as a diet containing a lot fruit and berries, soft and energy drinks and fruit juices seems to be the main exogenous cause of ETW among children and adolescents and seems to have considerable significance in the development of ETW [25,35,36]. The majority of the respondents found it important to advise ETW patients about healthy drinking and eating habits as well as the use of fluoride products. The recommendation on fluoride use can be considered as an important preventive treatment against ETW, since several studies have shown the anti-erosive effect of fluorides containing stannous fluoride. The reduction of ETW has been shown to be between 18 and 50% [3,37]. Advice on brushing techniques was considered important, although the scientific evidence concerning this is vague.
Addressing the challenges to increase the efficiency of translating nanomedicine formulations to patients
Published in Expert Opinion on Drug Discovery, 2021
Sourav Bhattacharjee, David J. Brayden
Radionuclide 99mTc-doped colloidal sulfur, with a decay half-life of six hours and availability in a wide range of sizes (100–300 nm), has been widely used for SPECT imaging as part of the lymphoscintigraphy investigation in melanoma and breast cancer patients [213]. Such a 99mTc-doped colloidal sulfur formulation, Technecoll® (Mallinckrodt Pharmaceuticals, Dublin, Ireland), was approved by the FDA in 1974 for both oral and parenteral administration, although the product was later discontinued [214]. With plasma elimination half-life (t1/2) of ~2.5 min, radionuclide-labeled colloidal sulfur showed an excellent capacity to map the sentinel lymph nodes and provided guidelines for surgical removal of the tumor en masse [215]. Similarly, 99mTc-doped colloidal stannous fluoride (<200 nm) was used for SPECT imaging [216]. Upon parenteral administration, these colloidal formulations accumulated mostly in the liver, followed by spleen, bone marrow, and lungs. However, in the case of a liver with compromised function, such as in cirrhosis and cancer, the major accumulation occurred in the spleen and bone marrow, a phenomenon known as the ‘colloid shift’ [217].
Salivary fluoride concentration and retention after rinsing with 0.05 and 0.2% sodium fluoride (NaF) compared with a new high F rinse containing 0.32% NaF
Published in Acta Odontologica Scandinavica, 2020
Kerstin Larsson, Alexander Stime, Lisa Hansen, Dowen Birkhed, Dan Ericson
Beside dental caries, a high F solution may also be useful for prevention of dental erosion. In a recent review by Huysmans et al. [15], the authors discuss various strategies to prevent dental wear. Although stannous fluoride (SnF2) has received increasing attention as a promising anti-erosive agent, the use of high concentrations of NaF in dentifrices and mouthrinses is also discussed. To date, there are no long-term clinical studies on the effects of F solutions in preventing erosion of enamel and dentine. A high F solution such as the 0.32% NaF solution tested in the present study, may have potential application as a daily rinse in patients at risk of erosion. In an in situ erosion remineralization model, Maggio et al. [23] studied the combination of NaF toothpaste (1450 ppm F) and NaF mouthrinse (450 ppm F). There was a significant effect on hardening of incipient erosive lesions of enamel and increased resistance to a second erosive challenge. In future studies it would be of interest to evaluate the effect of a 1450-ppm F rinse in this model.