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Belching/Burping
Published in Charles Theisler, Adjuvant Medical Care, 2023
OTC Products: A variety of over-the-counter products can be effective in relieving excess bloating depending on the cause, such as Lactaid or Dairy Ease to help digest lactose. Products containing simethicone (Gas-X, Mylanta Gas) can help reduce the feeling of bloating. Beano may decrease the amount of gas produced.
Nutritional and Dietary Supplementation during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
From a practical standpoint, it has no clear indications for use during pregnancy; neither does this agent offer any advantage over simethicone. However, activated charcoal should be used without hesitation when it is needed in the treatment of acute poisoning.
Colic and reflux in the breastfed baby
Published in Amy Brown, Wendy Jones, A Guide to Supporting Breastfeeding for the Medical Profession, 2019
Infacol (simethicone) reduces the surface tension of bubbles of gas trapped in liquid, so they join together. Dentinox (dimethicone) is similar. Although systematic reviews have failed to provide evidence of its efficacy in reducing colicky symptoms by reducing trapped gas in the liquid of the stomach, simethicone is still often used (Metcalf et al. 1994).
Diagnostic yield for video capsule endoscopy in gastrointestinal graft- versus -host disease: a systematic review and metaanalysis
Published in Scandinavian Journal of Gastroenterology, 2023
Jonas Varkey, Viktor Jonsson, Eva Hessman, Thomas De Lange, Per Hedenström, Mihai Oltean
Furthermore, the frequency of incomplete examinations was at an average of 12% ranging from 5–26%. The data was retrieved from four studies consisting of totally 237 examinations [26–28,30] which is acceptable according to European recommendation [33]. Overall, the retention rate seems to have declined globally over the past two decades [34] it still occurs at varying frequencies, depending on the indications, ranging from 2% in gastrointestinal bleeding [35] to 8–13% in Crohn’s disease [36,37]. However, these patients do not seem to have an elevated risk of retention if other complicating factors are not present. Therefore, the use of VCE in this patient cohort appeared safe since no serious adverse events were detected. The use of patency capsule is therefore not necessary if additional risk factors are not present. Several strategies such as administering propulsive agents prior to the procedure or placing the capsule directly in the duodenum with the help of a gastroscope may increase the completion rate by shortening the time spent in the stomach and saving battery time for the examination of the small and large intestine. Similarly, the use of Simethicone and bowel preparation would likely play a role in improving the visualization of the small bowel [38] but these agents seem to have been used in less than half of the patients.
Fabry disease – a multisystemic disease with gastrointestinal manifestations
Published in Gut Microbes, 2022
Some major GI symptoms in patients with FD can be treated with various concomitant drugs that are symptomatically effective. Patients with acute diarrhea can be treated with classical anti-diarrhea medication such as loperamid. By contrast, patients suffering from gastroparesis can benefit from treatments with pro-motility agents, such as metoclopramide, which increase the contractile force and accelerate intraluminal transit.68 Patients suffering from upper GI symptoms may benefit from proton pump inhibitors (e.g. omeprazole) or ondansetron if nausea is present.34 Medication against bloating and flatulence may include the administration of simethicone, which eliminates and prevents foam formation.69,70 Furthermore, linaclotide, which is an oligo-peptide agonist of guanylate cyclase 2C is used to treat IBS with constipation and chronic constipation with unknown cause.71,72 The antispasmodic dicyclomine, which blocks the action of acetylcholine on cholinergic receptors in smooth muscles in the GI tract, is used to treat spasms of the intestine in IBS,73 and might also be of relevance, although it should be used with caution, especially in patients with any unstable cardiac condition.
CC-CLEAR (Colon Capsule Cleansing Assessment and Report): the novel scale to evaluate the clinical impact of bowel preparation in capsule colonoscopy – a multicentric validation study
Published in Scandinavian Journal of Gastroenterology, 2022
Rui de Sousa Magalhães, Carolina Chálim Rebelo, Bernardo Sousa-Pinto, José Pereira, Pedro Boal Carvalho, Bruno Rosa, Maria J. Moreira, Maria A. Duarte, José Cotter
Bowel preparation was performed according to our center’s protocol [8–10]. Patients were instructed to have a low-fiber diet and ingest at least 10 glasses of water 2 days before the procedure. On the day before the procedure, a clear liquid diet was prescribed, as well as 1 L of polyethylene glycol solution plus ascorbate followed by 1 L of water between 7 and 9 pm. On the day of the procedure, another 1 L of this solution followed by 1 L of water was ingested (between 6:30 and 8:30 am), and fasting was warranted afterward. Thirty minutes before capsule ingestion, patients were given 100 mg of simethicone and 10 mg of domperidone. At 9 am, patients were instructed to ingest the capsule. One hour later, using the real-time viewing system, capsule progression to the small bowel was confirmed, and 10 mg of domperidone was administered if the capsule was still in the stomach. Thirty minutes later, capsule progression was assessed, and in the case of delayed stomach emptying, endoscopic capsule placement in the small bowel was performed. When the small bowel was reached, a booster of 30 mL of sodium phosphate solution (Fleet Phospho Soda; Casen-Fleet Laboratories, Madrid, Spain) was administered, followed by ingestion of 1 L of water; 3 h later, the second booster of sodium phosphate (15 mL) was administered, plus 500 mL of water. After another 3 h, if the capsule was not excreted, a bisacodyl suppository was given.