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Phytotherapeutic Agents in Epilepsy
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Sesamol is the major phenolic constituent of sesame seed oil obtained from Sesamum indicum, Linn. (Fam. Pedaliaceae) which has been traditionally used as a health supplement due to its antioxidant, anti-inflammatory, immunomodulatory, neuroptotective, and anti-aging properties. The plant extracts have demonstrated anticonvulsant activity in animal models of epilepsy.164 Recently, sesamol has been shown to exert ameliorative effects against seizures (PTZ model of epilepsy), cognitive impairment (elevated plus maze and passive avoidance tests), and oxidative stress (assessed by estimation of lipid peroxidation and reduced glutathione).165 This suggests that sesamol is responsible for the anticonvulsant activity of sesame oil and affirms the hypothesis that sesamol can be included as a beneficial adjuvant in antiepileptic therapy.
Nanophytomedicine
Published in Amritpal Singh Saroya, Contemporary Phytomedicines, 2017
Sesamol, a component of sesame seed oil, exhibited significant antioxidant activity in a battery of in vitro and ex vivo tests including lipid peroxidation induced in rat liver homogenates. S-SLNs prepared by the microemulsification method were administered to rats post-treatment with CCl4 (1 ml/kg body weight (BW) twice weekly for two weeks, followed by 1.5 ml/kg BW twice weekly for the subsequent two weeks). S-SLNs (120.30 nm) at a dose of 8 mg/kg BW showed significantly better hepatoprotection than corresponding dose of free sesamol (FS; p < 0.001). Effects achieved with S-SLNs were comparable with silymarin (SILY), administered at a dose of 25 mg/kg BW (Singh et al. 2015).
Sesamol Augments Paclitaxel-Induced Apoptosis in Human Cervical Cancer Cell Lines
Published in Nutrition and Cancer, 2022
Jiayi Xiong, Juanjuan Sheng, Yan Wei, Zhimin Sun, Xia Xiao, Lanmei Zhang
Paclitaxel is one of the significant anticancer drugs that have been prescribed for the treatment of cervical cancer. The additive/synergistic effect of chemosensitisers improves paclitaxel effect in the breast cancer cells. In the present study, it was found that sesamol pretreatment sensitized the paclitaxel-induced cytotoxicity in a concentration-dependent manner. Similarly, the radiosensitising potential of sesamol was already reported in the cervical cancer cell lines (26). Khamphio et al., 2016 illustrated the anticancer effect of sesamol in HCT116 human colon cancer cells through its prooxidant effect (27). In addition, sesamol exhibits chemosensitising properties in cancer cells through the up-regulation of mitochondrial death receptors (22). Conversely, Sesamol prevented chemotherapeutic drugs induced cytotoxicity and oxidative damage in normal cardiac cells (28). Sesamol augmented the chemotherapeutic drug efficacy in cancer cells and prevented their toxicity in normal cells. Similarly, the plant-derived phytochemicals improved the efficacy of anticancer drugs in experimental cancer cell lines and prevented their toxicity in normal cells (29–31).
Sesamin and sesamol attenuate H2O2-induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway
Published in Nutritional Neuroscience, 2021
Waralee Ruankham, Wilasinee Suwanjang, Prapimpun Wongchitrat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin
Sesame is widely known as a traditional medicine for treatment of various disorders including wound healing17, hyperlipidemia18, hypercholesterolemia19, and infertility20, as well as beauty enhancements.21–23 Both sesame seeds and oil are considered safe as food and ingredients in functional foods and nutraceuticals. The most abundant phenolic compounds found in sesame seeds and oil are sesamin and sesamol. These two compounds are reported to have many pharmacological properties. Several lines of evidence from a variety of in vivo and in vitro studies have revealed that the mechanisms underlying neurodegeneration remain to be fully elucidated.
Design and fabrication of Sesamol-loaded transfersomal gel for wound healing: physicochemical characterization and in-vivo evaluation
Published in Drug Development and Industrial Pharmacy, 2023
Nida Umam, Mohammad Ahmad, Poonam Kushwaha
Wounds result from the destruction of the normal anatomically lining tissue membrane, which includes trauma, tissue resection, and burns [1]. Wounds that become chronic due to co-existing conditions like diabetes or peripheral vascular disease may not heal promptly. In the postoperative period, wound infections may also fail to heal; it is estimated that up to 4% of patients with surgery suffer from such infections. Despite the associated high morbidity associated with chronic non-healing wounds, these wounds add substantially to the costs of medical care [2]. Since the last decade, naturally occurring phenolic compounds have received considerable attention for treating various skin diseases. In addition to their low toxicity, phenolic compounds possess a range of biological activities including antioxidant, anti-inflammatory, and antimicrobial properties. Research suggests that phenolic compounds can accelerate wound healing primarily through their ability to reduce reactive oxygen species (ROS) and inflammation developing in wounds, and as a result promote the induction of skin repair mechanisms [3]. Through clinical and preclinical studies, it has been identified that oxidative damage and inflammation are the main causes of nonhealing chronic wounds [4]. The phenolic compound Sesamol (SL) is a major lignan derived from sesame seeds (Sesamum indicum) and sesame oil. It has many nutritional and health benefits. Traditionally, sesame seed paste and its oil have been used for promoting healing in burns and other wounds. Studies have shown that SL can accelerate wound closure. Wound healing activity is influenced by antioxidants in a positive manner. Sesamol is known to be the main antioxidant contained in processed sesame oil. As a result of its antioxidant activity, it contributes to the repair of injured skin by inhibiting the overproduction of ROS responsible for wound pathogenesis [5]. Additionally, SL promotes cell proliferation by stimulating collagen synthesis and maturation in wound areas [6].