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Osteoarthritis
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Sesame oil has been used in traditional medicine to alleviate pain from inflammatory conditions. The oil is extracted from Sesamum indicum, and animal OA models show an ability for sesame oil to alleviate joint pain by inhibiting oxidative progression and serum inflammatory markers (Dragos et al., 2017). Human studies show that five tablespoons of sesame seeds in conjunction with standard drug therapy for OA led to improvement in pain and mobility after 2 months compared to control (Sadat et al., 2013). And in another study, the same amount of sesame seed was associated with a statistically significant drop in serum levels of IL-6 and C-reactive protein after 2 months of treatment (Haghighian et al., 2015).
Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Vegetable oils are lipid liquid extracted from different parts of plants such as seeds (rapeseed, sunflower seed), legumes (peanut, soybean), nuts (walnut, almond), or the flesh of some fruits (olives) (273–276). Vegetable oils are pressed from the plants and are then processed and refined to produce high-quality oils suitable for use as an ingredient in recipes, for frying, in salad dressings, and in the production of margarines and spreads (273). Culinary oils are liquid at room temperature. Major edible vegetable oils in terms of production include soybean, sunflower, palm oil, and rapeseed, which together account for approximately 79% of the total production in the world (273–275). Other oils such as olive oil, sesame oil, peanut oil, corn oil, canola oil, flaxseed oil, and coconut oil are also used for frying, salad dressing, and snack food processing. Some oils extracted from nuts like almond oil, walnut oil, cashew oil, and pine nut oil are very expensive and mainly used as flavoring agents or in traditional medicine. Oils obtained by distillation are called essences, which are mainly destined for medicinal or cosmetic uses.
Reproductive and Developmental Toxicity Studies by Cutaneous Administration
Published in Rhoda G. M. Wang, James B. Knaak, Howard I. Maibach, Health Risk Assessment, 2017
Rochelle W. Tyl, Raymond G. York, James L. Schardein
Sesame oil, a chemical used as an additive in food and drug formulations, had no developmental toxicity potential when applied dermally or subcutaneously at dosages in the range of 20 to 1000 mg/kg on gestational days 6 to 18 in the rabbit.82
Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis
Published in Drug Delivery, 2022
Khaled M. Hosny, Amal M. Sindi, Sarah Ali, Waleed S. Alharbi, Maher S. Hajjaj, Haitham A. Bukhary, Moutaz Y. Badr, Rayan Y. Mushtaq, Samar S. A. Murshid, Alshaimaa M. Almehmady, Rana B. Bakhaidar, Eman Alfayez, Mallesh Kurakula
Among the various pharmacotherapeutic drugs, antifungal drugs, mainly azoles, are the drugs of choice for treating OCA. Azole drugs act via inhibition of lanosterol demethylase and peroxidases, which are responsible for the formation of ergosterol, which causes OCA (Gheorghe et al., 2021). Among various azoles, miconazole (MZ) is extensively used and has shown significant clinical outcomes. However, MZ is a weak acid and poorly aqueous soluble drug and hence it shows lower bioavailability, as well as a limited therapeutic outcome (Gheorghe et al., 2021). Sesame oil (SO) is a commonly used vegetable oil obtained from Sesamum indicum. SO has been reported to have potent antioxidant, anti-inflammatory, immunoregulatory, antibacterial, and antiulcer potential in various preclinical studies. SO is a safe essential oil and has been endorsed by the United States Food and Drug Administration for use as an additive (Ogawa et al., 2014). MZ has proven effective as an antifungal drug but has pharmacokinetic limitations, and SO is a naturally occurring oil with proven effectiveness as an antioxidant, anti-inflammatory, and antiulcer agent. However, oils such as SO also suffer from the limitations of low aqueous solubility and instability, and hence, their widespread use is limited in the pharmaceutical industry (Zhang et al., 2016).
Comparing of the effects of sesame oil and rapeseed oil versus suet oil and animal butter on the reproductive system of male rats
Published in Clinical and Experimental Hypertension, 2022
Behrooz Yahyaei, Miromid Safari
Suet oil is categorized in the animal oils and popular in the Middle East and Africa. Sesame oil is mostly composed of unsaturated fatty acids with one or several unsaturated bonds (43.3% and 41.1%, respectively), oleic fatty acids (39.09%), linoleic (40.39%) and lignin, which has lots of phytosterol effects (10). Rapeseed oil is the second most important oil in the world after Soy Oil. This oil has lots of PUFAs. Rapeseed also contains tocopherol (100–115.9 milligrams/10 gram), phytosterol (459–500 milligrams/100gram), polyphenol (0–7.148 milligrams/100 grams) and other nutrients (11). According to the increasing rate of infertility among men and lack of enough molecular evidences about the effects of various diets on male fertility, this study aimed to determine the effect of rapeseed and sesame oil, in comparison with the animal butter and suet oil, on the reproductive system and sperm quality of male rats.
Effectiveness of aromatherapy in reducing duration of labour: a systematic review
Published in Journal of Obstetrics and Gynaecology, 2022
Ashraf Ghiasi, Leila Bagheri, Fatemeh Sharaflari
Sesame (Sesamum indicum L.) a member of Pedaliaceae family, has analgesic activity due to presence of acetic acid in it. Acetic acid causes algesia by liberation of endogenous substances, which then excite the pain nerve endings (Bawa et al. 2010). Pain and fear cause stress. Stress can increase adrenaline secretion. When adrenaline secret blood vessels contracted so the maternal and foetal oxygen supply decreases. Decreased blood flow also causes weakening of uterine contractions and results in prolonged labour (Ria et al. 2020). In a study conducted by Askari, the experimental group received massage with sesame oil while the placebo group received massage with liquid oil. The results revealed the significant difference between the mean duration of three-stage of labour in experimental and control group (Askari et al. 2016).