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Conjunctivitis/Pinkeye
Published in Charles Theisler, Adjuvant Medical Care, 2023
Riboflavin: Riboflavin deficiency usually occurs with other B vitamin deficiencies. Symptoms and signs include conjunctivitis, sore throat, lesions of the lips and mucosa of the mouth, glossitis, seborrheic dermatitis, and normochromic-normocytic anemia.
Nutritional Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Chelsea Kesty, Madeline Hooper, Erin McClure, Emily Chea, Cynthia Bartus
Overview: Riboflavin deficiency is relatively rare, but it can occur in malnourished patients (anorexia nervosa, malignancy, and malabsorptive state, such as celiac disease and short bowel syndrome), long-term users of phenobarbital, and patients with very restricted diets. It may also be found in breastfed infants whose mothers are riboflavin deficient. Symptoms are nonspecific, and riboflavin deficiency is usually accompanied by other coexisting vitamin deficiencies.
Micronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Vitamin B2 or riboflavin is an essential vitamin of group B. It is a water-soluble, yellow-orange organic compound and is heat stable. Riboflavin is the central component of the coenzymes: flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), and acts as a co-factor in numerous enzymatic reactions. It is therefore important for energy production, enzyme function, and normal protein, fatty acid and amino acid synthesis (3, 9, 33, 37–38). It mediates the transfer of electrons in biological oxidation-reduction reactions. It is also involved in the metabolism of folate, vitamin B12, vitamin B6, and other vitamins. It also helps to maintain the integrity of mucous membranes, skin, the eyes and nervous system (38). The role of riboflavin has also been credited in the prevention of a wide array of health diseases like migraine, anemia, cancer, hyperglycemia, hypertension, diabetes mellitus, and oxidative stress, directly or indirectly (38). A deficiency of riboflavin named ariboflavinosis is manifested in swollen tongue, skin eruption, and eye irritation (3, 33, 37–38). Riboflavin deficiency has profound effects on iron absorption, metabolism of tryptophan, mitochondrial dysfunction, the gastrointestinal tract, brain dysfunction, and metabolism of other vitamins (38). Although riboflavin is involved in all areas of metabolism, and deficiency is widespread on a global scale, deficiency is not fatal (33). Riboflavin deficiency is usually associated with other vitamin B complex deficiencies; isolated riboflavin deficiency is rare (3, 33).
The relationship between anemia and obesity
Published in Expert Review of Hematology, 2022
Ramadan A. Saad, Haitham MohammedHabib Qutob
Reduced dietary intake of needed nutrients, increased loss of nutrients due to blood loss caused by parasites or hemorrhage, impaired intestinal absorption of some nutrients such as vitamin B12 due to a lack of intrinsic factor (IF) or iron due to Helicobacter pylori infection, or altered nutrient metabolism such as vitamin A or riboflavin deficiency are the most common causes of nutrient deficiency [31]. In addition, autoimmune gastritis (AIG) is a chronic inflammatory condition characterized by the loss of parietal cells in the stomach’s mucosa, and vitamin B12 deficiency is the most common consequence [32]. Although AIG reduces iron and vitamin B12 absorption, iron deficiency is discovered at a younger age and many years before the development of pernicious anemia. Pernicious anemia is a relatively late diagnosis in AIG and is most commonly identified in older people. This could be explained by both low turnover (2–3 g per day) with substantial storage (2–5 mg) and decreases in vitamin B12 absorption with age [33]. Iron insufficiency, often known as hypoferraemia, is the most common single micronutrient deficit worldwide. Untreated iron deficiency can lead to iron deficiency anemia, a serious health disease characterized by fatigue, decreased life productivity, and poor maternal health, particularly in pregnant women [34] (Table 1).
Skin damage in a patient with lipid storage myopathy with a novel ETFDH mutation responsive to riboflavin
Published in International Journal of Neuroscience, 2020
Hongliang Xu, Xin Chen, Yajun Lian, Shuya Wang, Tuo Ji, Lu Zhang, Shuang Li
In addition, symptoms related to riboflavin deficiency include lesions and inflammation of lips (cheilosis), inflammation of the tongue and oral cavity, seborrheic dermatitis (an inflammatory skin condition), neuropathy, and anemia [35]. However, none of these symptoms were revealed in this patient and nutrition state of the patient was well. Therefore, we cannot ascribe the skin lesion to riboflavin deficiency. We consider that the skin damage was related to the lipid storage myopathy, and might be a rare symptom of ETFDH mutation. To our knowledge, this is the first reported skin lesion associated with MADD caused by ETFDH mutation and is a novel type of skin damage responsive to riboflavin.
Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism
Published in Nutrition and Cancer, 2019
Wipa Chantarawong, Nattakorn Kuncharoen, Somboon Tanasupawat, Pithi Chanvorachote
Lumichrome (7,8-dimethylalloxazine) is one major derivative of vitamin B2 or riboflavin (7,8-dimethyl-10-ribityl-isoalloxazine). Riboflavin plays an important role in protein, fat, and carbohydrate metabolism and is critical for maintaining energy supply (26). Regarding the effect of riboflavin on cancer, one piece of evidence has suggested that high doses of riboflavin might promote lung cancer progression (27). In addition, riboflavin deficiency has inhibited tumor growth in experimental animals (28). Unlike riboflavin, only limited information has been reported on the effect of lumichrome on cancer cells.