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Evaluation of the Potential of Microspherical Systems for Regional Therapy in the Tumor-Bearing Liver and Kidney Using Techniques in Nuclear Medicine
Published in Neville Willmott, John Daly, Microspheres and Regional Cancer Therapy, 2020
Jacqueline A. Goldberg, James H. McKillop, Colin S. McArdle
For all of the iodine tracers, it is important to remember that radionuclide which becomes detached from the microsphere, either because of leaching of the label or breakup of the microsphere, will concentrate in the thyroid. To protect the thyroid from an excessive radiation dose it is necessary to block uptake using either oral potassium iodide or potassium iodate. The duration of the blocking therapy will vary according to the particular radioisotope of iodine being used, the rate of breakup of the radiolabeled protein, and the administered activity.7 For 99mTc, 111In, and 113m In, blockade is unnecessary.
The internal radiation hazard
Published in Alan Martin, Sam Harbison, Karen Beach, Peter Cole, An Introduction to Radiation Protection, 2018
Alan Martin, Sam Harbison, Karen Beach, Peter Cole
The absorption of certain radioisotopes can be blocked by the prior ingestion of substantial amounts of a stable isotope of the same element. For example, the uptake of radioiodine to the thyroid can be greatly reduced by previous ingestion of potassium iodate or potassium iodide. The usual adult dose is 100 mg iodine equivalent, generally in tablet form. This has an important application in the event of a nuclear reactor accident.
What is iodine?
Published in Tatsuo Kaiho, Iodine Made Simple, 2017
Iodine is an essential element for living creatures. Iodine deficiency is caused by a lack of iodine intake. In Western countries, potassium iodate is added to table salt. Iodine is also indispensable for livestock and is provided as a feed additive [1].
Interference of preservatives on urinary iodine measurement by Sandell–Kolthoff method
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 2022
Elif Kaya, Murat Usta, Ömer Emecen, Sembol Yıldırmak
The method based on the Sandell-Kolthoff reaction was used for urinary iodine measurement [3,7]. Among the various modified applications based on the classical photometric Sandell-Kolthoff method, the Ohashi's microplate method with ammonium persulfate digestion was performed [4]. The absorbances were measured at 405 nm in a microplate reader (AccuReader M965/965+, Metertech Inc., Version 1.13, Taiwan) at 22°±1 °C for the reaction mixtures in microplates. The five levels of potassium iodate (KIO3) solutions were used as standards. The results were expressed as µmol/L.
An accidental exposure to dimethyl sulfate
Published in Clinical Toxicology, 2019
Xuetao Zhang, Zhihong Wang, Xiaoqin Tang, Zubing Wang
The incident was a consequence of the courier sender who transported the hazardous chemicals illegally. He admitted that the liquid was DMS. The accident scene was blocked by the police; unfortunately toxic substances in the workshop were not tested. The chemical composition of the liquid was determined by the solid-liquid mass spectrometer. It was confirmed that the main composition was dimethyl sulfate; a small amount of iodoethane, potassium iodate and chromyl chloride were also found.