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An Overview of Molecular Nutrition
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Vincent W. Li, Catherine Ward, Delaney K. Schurr
Vitamin K1, or phytomenadione, is the most common form of vitamin K in the diet and is found mainly in green leafy vegetables. It’s most commonly known for its role in blood clotting. There is another less recognized form of vitamin K known as vitamin K2 (menaquinone) that is particularly notable for its antiangiogenic properties. In 2009, a research group in Japan found that vitamin K2 was capable of suppressing blood vessel growth and through this mechanism also suppressing colon cancer cells (Kayashima et al., 2009). Another study demonstrated this antiangiogenic effect in prostate cancer cells (Samykutty et al., 2013). Vitamin K2 is found in specific age-ripened hard cheeses like Gouda, Edam, and Müenster cheese but not in other cheeses such as feta, mozzarella, Pecorino, or Parmesan (Vermeer et al., 2018).
Pregnancy, Delivery and Postpartum
Published in Miriam Orcutt, Clare Shortall, Sarah Walpole, Aula Abbara, Sylvia Garry, Rita Issa, Alimuddin Zumla, Ibrahim Abubakar, Handbook of Refugee Health, 2021
Zahra Ameen, Katy Kuhrt, Kopal Singhal Agarwal, Chawan Baran, Rebecca Best, Maria Garcia de Frutos, Miranda Geddes-Barton, Laura Bridle, Black Benjamin
Vitamin K is helpful for women being treated with an enzyme inductor (e.g. rifampicin, rifabutin, carbamazepine, phenobarbital or phenytoin). Administer 10 mg/day phytomenadione orally in the 15 days preceding the due date.
Heart disease in the elderly
Published in Clive Handler, Gerry Coghlan, Nick Brown, Management of Cardiac Problems in Primary Care, 2018
Clive Handler, Gerry Coghlan, Nick Brown
The patient does not need to be referred immediately to hospital. The warfarin should be stopped, and it should only be restarted when the INR is < 5.0. Phytomenadione should be given if there are other risk factors for bleeding.
An outbreak of severe coagulopathy in northern Israel among users of illicit synthetic cannabinoids adulterated with brodifacoum
Published in Clinical Toxicology, 2023
Yael Lurie, Yona Nadir, Ron Hoffman, Asaf Miller, Edna Efrati, Gil Ring, Dana Sonenfeld, Nitai Bar, Hisam Zaidani, Alexander Strizevsky, Mahdi Asali, Ophir Lavon, Daniel Kurnik
The index case leading to the recognition of the coagulopathy outbreak was a 42-year-old man who presented to the ED with gross hematuria and fatigue on 22 October 2021. He was a chronic user of ethanol and illicit drugs and reported smoking “Nice Guy” prior to his admission. On admission, his heart rate was 102 beats/minute and his blood pressure was 143/91 mmHg. The initial hemoglobin concentration was 167 g/L but decreased to 125 g/L during the following days, and the platelet count was normal. In coagulation studies, the blood did not coagulate. Abdominal non-contrast computed tomography (CT) showed hyperdense thickening of the urothelium in the right renal pelvis and proximal ureter, consistent with suburothelial hemorrhage. His urine immunoassay screen test detected benzoylecgonine (cocaine metabolite). The serum creatinine and bilirubin concentrations and liver enzyme activities were within the normal range. He denied taking anticoagulants or any other prescription medications. The initial treatment included intravenous administration of phytomenadione (vitamin K1) 10 mg given as a short infusion and two units of fresh frozen plasma.
Fabrication and evaluation of Phytomenadione as a nanostructure lipid carrier for enhancement of bioavailability
Published in Pharmaceutical Development and Technology, 2018
Bader Mubarak Aljaeid, Khaled Mohamed Hosny
This work aims to formulate and characterize a stable NLC of Phytomenadione to improve its bioavailability. The prepared formulas will be thoroughly evaluated in vitro, and according to the results of in vitro evaluation, the selected formula will be used in the in vivo pharmacokinetic study in rabbits.