China
Africa
Explore chapters and articles related to this topic
The Place of Primary Cardiac Stress Damage in the Pathogenesis of Arrhythmias, Ischemic Disease, and Sudden Cardiac Death
Published in Felix Z. Meerson, Alexander V. Galkin, Adaptive Protection of The Heart: Protecting Against Stress and Ischemic Damage, 2019
Felix Z. Meerson, Alexander V. Galkin
Second, along with the complete absence of myocardial ischemia and rather high tolerance to physical loads in such arrhythmias there often are defects in specific stress-limiting systems which will be specially considered later. Thus Skibitskii52 has shown that in 40 patients with neurocirculatory dystonia suffering from attacks of paroxysmal supraventricular tachycardia, a GABA derivative phenibut (acting like the known GABA-receptor activator baclophen) decreased the number of attacks by a factor of 5.5 and prolonged the fitless period to 6 months. In half of 32 patients with ventricular extrasystole, this activator of the GABA-ergic system completely abolished or decreased the number of extrasystoles by 75% or more. The antiarrhythmic effect was observed not only in neurocirculatory dystonia, but also in IHD, and was accompanied by a positive psychotropic effect. It is known that the GABA-ergic system can be activated via the benzodiazepine receptors; accordingly, benzodiazepine receptor agonists have been also successfully used as antiarrhythmics.
Quantity of phenibut in dietary supplements before and after FDA warnings
Published in Clinical Toxicology, 2022
Pieter A. Cohen, Ross R. Ellison, John C. Travis, Slava V. Gaufberg, Roy Gerona
Phenibut (beta-phenyl-gamma-aminobutyric acid) is a gamma-aminobutyric acid-B (GABA-B) agonist, structurally similar to baclofen, and prescribed in Russia and elsewhere to treat anxiety, insomnia, alcohol withdrawal and other conditions [1]. The evidence to support these treatments is limited. However, the drug’s risks have been well described. Phenibut has the potential to produce physical dependence, withdrawal and addiction [2]. In the United States, poison control centers have received more than 1,300 calls involving phenibut, the great majority since 2015 [3]. Lethargy, agitation, tachycardia and confusion are among the most commonly reported symptoms to poison control centers. Life-threatening adverse events from overdose and withdrawal include delirium, psychosis and coma [2,3]. In a recent study from the Centers for Disease Control and Prevention, life-threatening reactions or long-term disability occurred in 1 in 8 reported exposures to phenibut, including 80 cases of coma and three deaths [3].