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Introduction
Published in Robert Fried, Richard M. Carlton, Flaxseed, 2023
Robert Fried, Richard M. Carlton
Most people who follow a Western Diet typically consume too many omega-6 fats, like linoleic acid, and not enough omega-3 fats, like ALA. For that reason, golden flaxseed is a better choice for supplementing the diet with healthy fats. However, brown flaxseed has a substantially higher concentration of antioxidants. In fact, compared to other similar seeds, like chia seeds and perilla seeds, golden flaxseeds are always the lowest in antioxidants. (32) Perilla, by the way, is a kind of mint.
Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
In folk medicine the antispasmodic, diaphoretic, sedative herb is prescribed for cephalic pulmonary and uterine trouble. Reported to be alexeteric, anodyne, antidotal, antiseptic, antitussive, carminative, diaphoretic, expectorant, febrifuge, pectoral, preventitive (cold), sedative, stomachic, and tonic, perilla is a folk remedy for asthma, bronchitis, cephalgia, chest, cholera, colds, cough, fish poison, flu, malaria, nausea, pregnancy, rheumatism, spasm, sunstroke, and uteritis.32 In Korea the leaves are used for colds, cough, and dyspepsia.
An Overview of Hepatocellular Carcinoma with Emphasis on Dietary Products and Herbal Remedies
Published in Nutrition and Cancer, 2022
Deepa S. Mandlik, Satish K. Mandlik
Celery (Apium graveolens L.) is a common vegetable all over the world. Its seeds are traditionally used to treat liver disorders because of their potent antioxidant and anti-inflammatory properties. Apigenin, linamarose, and vitamins A and C were found to be the most bioactive constituents in celery seeds, according to a phytochemical study. Chemically induced hepatocarcinogenesis was inhibited in rats pretreated with celery seed extracts, as demonstrated by a decrease in γ-GT positive foci (67). The cytotoxicity of mung bean sprouts (MBS) extract on HepG2 cells and normal human cells were different. Stimulation of apoptosis (Bax and caspase-8), the rise of anti-tumor cytokines (TNF-α and IFN-β), the elevation of IFN-γ development, and enhancement of cell-mediated immunity were among the mechanisms underlying MBS anti-tumor properties (68). The leaves of Perilla frutescens L. are eaten as a vegetable and are commonly used for their sweet fragrance. The extracts obtained of several plants, such as caffeic acid, rosmarinic acid and apigenin have been shown to have anti-proliferative properties against a variety of cancers. According to one study, isoegomaketone extracted from P. frutescens, repressed cell progression and xenograft tumor development in HCC cells, most likely by blocking the PI3K/Akt signaling pathway (69).
Luteolin restored Treg/Th17 balance to ameliorate allergic rhinitis in a mouse model
Published in Immunopharmacology and Immunotoxicology, 2023
Yuping Yang, Lingling Wang, Song Wang, Yan Wang, Yunqiang Du, Yuqin Fan
Currently, pharmacotherapy is the main therapy for AR, the therapeutic efficacy of which has been strongly supported by accumulating evidence. However, a part of AR patients poorly respond to the existing drugs. Moreover, the high cost and the side effects cannot be ignored as well [10]. Applied in clinical treatment of multiple diseases for thousands of years in China, traditional Chinese medicine is well-known for its excellent therapeutic effects together with the advantages of the low cost and little side effects, thereby drawing great attention worldwide [11,12]. Belonging to the Lamiaceae family, Perilla frutescens is extensively used in Asian countries for treatment of allergic diseases comprising bronchial asthma and AR. Polysaccharides, saponins, and flavonoids are the main components of the herb [13–15]. As the active constituent of Perilla frutescens, luteolin (LO) is a flavonoid proven to possess the anti-allergic activity [13,16,17]. Previous works have demonstrated that LO can alleviate mucus overproduction and inflammation in the airway of asthmatic animals [18,19]. Jang et al. have revealed that LO decreases inflammatory cells in bronchoalveolar lavage fluid and attenuates cell infiltration in the nasal tissue and pulmonary parenchyma of mouse with allergic asthma and rhinitis [20]. With regard to the relevant mechanisms, most studies focus on the role of LO in innate immune response and airway epithelial cells [21–23], while a few papers has affirmed the crucial functions of LO on Th1/Th2 imbalance involved in AR [10,24]. Nevertheless, there remains much room for investigation on the mechanism of LO in AR, which motivated us to do this research.
Triticum aestivum Sprouts Extract Inhibits Azoymethane (AOM)/Dextran Sodium Sulfate (DSS)-Induced Colon Carcinogenesis in Mice
Published in Nutrition and Cancer, 2018
Hyeon-Hui Ki, Ji-Hyun Lee, Hoon-Yeon Lee, Young-Mi Lee, Dae-Ki Kim
As described in previous studies, HPLC profiling of TAEE showed that polyunsaturated fatty acid like α-linolenic acid and glycolipids and sterols (22,44). Several reports suggested that α-linolenic acid has anti-inflammatory potential in DSS-induced colitis (45) and dietary perilla oil rich in α-linolenic acid reduced colon carcinogenesis in rats (46). And some glycolipids also have anti-inflammatory activity through inhibiting COX-2 pathway (47). However, further studies are needed to determine which compounds are involved in these inhibitory effects of TAEE on colon inflammation and carcinogenesis.