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Infections
Published in Charles Theisler, Adjuvant Medical Care, 2023
Oregano oil contains high levels of carvacrol and thymol which have been shown to be effective in vitro against a range of gram positive and gram negative microorganisms, including Staphylococcus aureus and/or Staphylococcus epidermidis, listeria, proteus, pseudomonas, salmonella, and clostridium species.2,3 Oregano has also inhibited aflatoxin production and prevented growth of aspergillus.3 Thymol in oregano oil was found to be an effective treatment for common candida fungal infections.4 Ingesting oregano oil supplements (e.g., 200 mg emulsified O. vulgare oil/day for six weeks) or rubbing the oil on the infected area can help make use of these antibacterial effects.2 Applying diluted oregano oil to the skin may help protect cuts and scrapes on the skin as they heal.1
Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Oregano (Origanum vulgare), belonging to family Lamiaceae, is a perennial herb native to temperate regions like Mediterranean and Eurasian countries. The leaf is used as medicine, culinary spice and food preservative. The major components associated with antimicrobial activities in oregano include carvacrol and thymol which are terpenoid phenols (248, 294). In ancient Greek and Roman empires, applications of the leaves on the skin were used as an antiseptic and to treat skin sores and aching muscles (cramping) (294). Nowadays, in Western traditional medicine, oregano oil is used to treat cold and troubles of the respiratory and digestive tracts (248, 294). Based on the current scientific literature, oregano extracts have demonstrated antimicrobial effects in vitro, especially on Salmonella serotypes, although the capacity to counter human infections was not well-studied (248, 294). Some preliminary studies showed that oregano exhibited benefits toward the cardiovascular and nervous systems, relieved symptoms of inflammation, and modulated blood sugar and lipids. Well-controlled human studies substantiating these health effects were lacking (294). More research are needed for oregano leaf extracts.
Herbal Product Development and Characteristics
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Mirian Pateiro, Rubén Domínguez, Predrag Putnik, Danijela Bursać Kovačević, Francisco J. Barba, Paulo S. E. Munekata, Elena Movilla Fierro, José M. Lorenzo
Oregano is yet another herb of the Laminaceae family, cultivated in the Mediterranean area since ancient times (Figure 8.1) (Mahmoud et al., 2004). There are more than 20 species included in the genus Origanum, being Origanum vulgare L. and Origanum majorana L. the most relevant for their medicinal activity (Uritu et al., 2018). For this purpose, dried leaves and flowering tops of the aforementioned species are used (Table 8.1). Among the main beneficial properties of this herb include pasmodic, antimicrobial, digestive, and expectorant activities (Teixeira et al., 2013). Regarding its antimicrobial activity, O. majorana L. is able to inhibit the formation of microbial metabolites, and has properties related to cardiovascular disorders, such as vasodilatatory effects, and it is capable to prevent atrial fibrillation (Floria et al., 2015; Marino et al., 2001).
Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia
Published in Drug Delivery, 2022
Khaled M. Hosny, Waleed Y. Rizg, Eman Alfayez, Samar S. Elgebaly, Abdulmohsin J. Alamoudi, Raed I. Felimban, Hossam H. Tayeb, Rayan Y. Mushtaq, Awaji Y. Safhi, Majed Alharbi, Alshaimaa M. Almehmady
Notably, the perturbation diagram, contour, and 3 D-surface plot of drug Jss response (Figure 1), revealed that oregano oil level had the most significant effect on Jss as increasing oregano oil levels (factor C) would highly facilitate drug permeation across rat skin. These findings can be understood in the light of oregano oil chemical composition. Carvacrol, which is the major component of oregano oil, was well known as a skin permeation enhancer that could efficiently deliver FI through the excised rat skin owing to its hydrogen-binding ability via the hydroxyl group and aromaticity (Songkro et al., 2009), hence, it could disorganize the close packing pattern of intercellular lipid matrix of skin layers (Williams & Barry, 2004). Besides, the amount of alkyl acrylate (factor B) had a positive effect on drug permeation across skins, as the increase in its amount caused a slight increase in FI penetration across skin. Such effect could be due to the emulsifying and penetration enhancing nature of alkyl acrylate which could have integrated with skin lipids to form channels that would facilitate drug permeation, comparable results were mentioned in literature (Kizeviciene et al., 2017; Shin et al., 2001).
Lippia graveolens HBK oleoresins, extracted by supercritical fluids, showed bactericidal activity against multidrug resistance Enterococcus faecalis and Staphylococcus aureus strains
Published in Drug Development and Industrial Pharmacy, 2021
Oscar de Jesús Calva-Cruz, Nallely S. Badillo-Larios, Antonio De León-Rodríguez, Eduardo Espitia-Rangel, Raúl González-García, Edgar Alejandro Turrubiartes-Martinez, Arnulfo Castro-Gallardo, Ana Paulina Barba de la Rosa
Oregano essential oils contain up to 56 compounds in different proportions depending on the species, but two of them, thymol and carvacrol, are of great importance because they determine the quality and price in the market [10–13]. Traditionally oregano oil has been used as an antiparasitic, antibacterial, antifungal, antiviral, and anti-inflammatory [14–19]. Reports also have indicated that oregano essential oils are used to treat liver and respiratory diseases as well as dyslipidemia in type-2 diabetic rats [20], the antimutagenic and antiproliferative activity have also been reported [21–23]. The microbicidal activity of Origanum vulgare essential oil has been tested in reference strains [24,25] as well as in some MDR bacteria [26], against pathogenic strains, such as S. aureus, Escherichia coli, and Candida albicans [27,28] and on biofilm-grown S. aureus, Staphyloccoccus epidermidis, and Salmonella enterica strains [29,30]. Origanum glandulosum essential oil was tested against uropathogenic E. coli including MDR strains [31].
Dietary oregano extract (Origanum vulgare L.) enhances the antioxidant defence in rainbow trout, Oncorhynchus mykiss against toxicity induced by organophosphorus pesticide, diazinon
Published in Toxin Reviews, 2020
Ahmad Rafieepour, Saeed Hajirezaee, Ruhollah Rahimi
The medicinal plant, oregano, Origanum vulgare is an important Mediterranean herb rich in polyphenols, thymol, and carvacrol with antioxidant and antimicrobial activities (Lagouri et al.1993; Chun et al.2005). The ability of oregano in scavenging the ROS produced during oxidative stress has been confirmed in many studies (Lagouri et al.1993; Yanishlieva et al.1999; Kulisic et al.2004). Furthermore, several studies have shown the immunostimulating and antioxidant role of oregano in fish (Zheng et al.2009; Abdel-Latif and Khalil 2014; Haghighi and Rohani 2015; Diler et al.2017). However, there is no information associated with the protective properties of oregano against ROS resulting from pesticide-induced oxidative stress.